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1.
Clin Oncol (R Coll Radiol) ; 36(6): 362-369, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38575431

ABSTRACT

AIMS: Evidence shows stereotactic ablative body radiotherapy (SABR) is used as a non-invasive ablative therapy in the treatment of multisite oligometastatic (OM) and oligoprogressive (OP) diseases originating from metastatic breast cancer. This study aims to report the treatment outcomes and to investigate what factors that are prognostic in terms of local control, progression-free survival (PFS) and overall survival (OS) in patients receiving SABR for extracranial OM and OP diseases originating from metastatic breast cancer. MATERIALS AND METHODS: A retrospective review on treatment records of patients with OM and OP from metastatic breast cancer who underwent SABR at a single was carried out. SABR was performed with daily image-guided radiotherapy (IGRT) using a dedicated robotic SABR machine. Local control, PFS and OS were calculated using Kaplan-Meier statistics and the post-treatment toxicity data was scored following the CTCAE v4.0 protocol. Univariate and multivariate Cox regression tests were used in the subgroup analysis of prognostic factors on PFS and OS including patients' age, types of follow-up imaging (staging CT only vs whole-body MR/PET), metastases status (OM vs OP), primary breast cancer tumour grade, hormone receptors (ER/PR/HER2) status, change of systemic treatments at SABR, number of metastases, SABR treatment sites and doses. RESULTS: 56 metastatic breast cancer patients (38 patients with OM and 18 patients with OP) were involved in this retrospective review. The median follow-up was 35.6 months (range 4.0-132.9 months). The estimated local control at 1 , 2 and 5 years were 90.9%, 88.7% and 88.7%, respectively. The estimated median PFS was 19.2 months (95%CI 10.3-28.1 months); the PFS at 1, 2 and 5 years were 63.3%, 44.4% and 33.2%. The estimated OS at 1, 2 and 5 years were 98.0%, 91.9% and 74.3%, respectively with the estimated median OS of 105.1 months (95%CI 51.5-158.7 months). The vast majority of patients tolerated the treatment well with the commonest acute side effects as grade 1 fatigue. There were no statistically significant factors found in OS regression analysis. The types of follow-up imaging, metastases status, oestrogen receptor status, and number of metastases for SABR were statistically significant factors (p < 0.05) in the multivariate Cox regression analysis on PFS. CONCLUSION: There are limited studies published on the efficacy and post-treatment toxicities of metastatic breast cancer OM and OP SABR with adequate length of follow-up. This study confirmed that SABR was a safe, non-invasive treatment option for patients with extracranial OM and OP diseases originated from primary breast cancer in terms of the acceptable post-treatment toxicities.


Subject(s)
Breast Neoplasms , Radiosurgery , Humans , Breast Neoplasms/pathology , Breast Neoplasms/radiotherapy , Female , Radiosurgery/methods , Retrospective Studies , Middle Aged , Aged , Adult , Treatment Outcome , Aged, 80 and over , Neoplasm Metastasis , Prognosis
2.
J Hosp Infect ; 135: 139-144, 2023 May.
Article in English | MEDLINE | ID: mdl-36958701

ABSTRACT

Monkeypox virus (mpxv) is a DNA virus in the Orthopoxvirus genus which causes Mpox (previously monkeypox). Symptoms include fever, lymphadenopathy and vesicular lesions. There is limited evidence for the duration of mpxv infectivity. This study used cell culture as a proxy for infectivity. Clinical samples from four patients with Mpox were inoculated into African green monkey kidney (Vero E6) cells and monitored for cytopathic effects (CPE). From one patient, infectious mpxv was recovered 25 days after illness onset. Infectious virus was not isolated from samples with an Orthopoxvirus polymerase chain reaction (PCR) Ct value over 31.0, nor from urine.


Subject(s)
Mpox (monkeypox) , Animals , Chlorocebus aethiops , Mpox (monkeypox)/diagnosis , Monkeypox virus/genetics , Polymerase Chain Reaction
3.
Front Sports Act Living ; 4: 898738, 2022.
Article in English | MEDLINE | ID: mdl-35711854

ABSTRACT

Purpose: Physical education (PE) lags behind community-based sport and physical activity programs in the integration of positive youth development (PYD) principles and practices such as teaching transferable life skills. However, research and educational policy indicates this can and should be part of the PE curriculum. Therefore, there is a significant need to explore students' perceptions and experiences about learning life skills within the PE context. In the current study, an intervention based in a wellestablished PYD approach called Teaching Personal and Social Responsibility (TPSR), was delivered to assess these issues. Methods: The current study was conducted in the mid-western U.S. Participants were 122 adolescent students (m = 60, f = 62; M = 12.48 years, SD = 0.97 years) in intervention and control classes. For the intervention, a PE teacher received training on the TPSR approach to promote life skills, while the control teacher received no training and participated in usual practices. Pre- and post-surveys were distributed that examined student perceptions about learning life skills, and supplemental systematic observations were recorded to capture the intervention teacher's fidelity to the TPSR model. Results: Results indicated that the intervention group students' perceptions of in-class experiences with life skills such as problem solving, emotional regulation, effort, goal setting, identity experiences, time management, and promoting social norms were enhanced overtime, compared to the control group. Conclusion: PE is in a unique position to promote PYD in the school curriculum by teaching of life skills. In this case, participants in the intervention group demonstrated learning personally and socially responsible behaviors across the course of 15 PE lessons. Future research should examine if changed in-class perceptions about life skills can foster use of these skills outside of the PE setting.

4.
J Eat Disord ; 9(1): 112, 2021 Sep 14.
Article in English | MEDLINE | ID: mdl-34521470

ABSTRACT

BACKGROUND: Early response to treatment has been shown to be a predictor of later clinical outcomes in eating disorders (EDs). Specifically, early weight gain trajectories in anorexia nervosa (AN) have been shown to predict higher rates of later remission in inpatient treatment. However, no study has, as of yet, examined this phenomenon within outpatient treatment of first episode cases of AN or in emerging adults. METHODS: One hundred seven patients with AN, all between the ages of 16 and 25 and with an illness duration of < 3 years, received treatment via the first episode rapid early intervention in eating disorders (FREED) service pathway. Weight was recorded routinely across early treatment sessions and recovery outcomes (BMI > 18.5 kg/m2 and eating psychopathology) were assessed up to 1 year later. Early weight gain across the first 12 treatment sessions was investigated using latent growth mixture modelling to determine distinct classes of change. Follow-up clinical outcomes and remission rates were compared between classes, and individual and clinical characteristics at baseline (treatment start) were tested as potential predictors. RESULTS: Four classes of early treatment trajectory were identified. Three of these classes (n = 95), though differing in their early change trajectories, showed substantial improvement in clinical outcomes at final follow-up. One smaller class (n = 12), characterised by a 'higher' start BMI (> 17) and no early weight gain, showed negligible improvement 1 year later. Of the three treatment responding groups, levels of purging, depression, and patient reported carer expressed emotion (in the form of high expectations and low tolerance of the patient) determined class membership, although these findings were not significant after correcting for multiple testing. A higher BMI at treatment start was not sufficient to predict optimal clinical outcomes. CONCLUSION: First episode cases of AN treated via FREED fit into four distinct early response trajectory classes. These may represent subtypes of first episode AN patients. Three of these four trajectories included patients with substantial improvements 1 year later. For those in the non-response trajectory class, treatment adjustments or augmentations could be considered earlier, i.e., at treatment session 12.


A key feature of anorexia nervosa (AN) is an unhealthily low body weight. Previous studies show that more weight gained early in inpatient treatment leads to better outcomes. This study tried to see if this was also true for outpatients receiving treatment for the first time. All participants were emerging adults between the ages of 16 and 25 who had been ill for less than 3 years. Weight was recorded across the first 12 weekly treatment sessions. Statistics showed that the patients fit roughly into four different groups in early treatment, each with different starting weights and rates of weight gain in the first 12 treatment sessions. The group a patient belonged to could sometimes be predicted by vomiting behaviours, level of depression, and patients' perception of parental tolerance and expectations at the start of treatment. Out of the four groups, three did relatively well 1 year later, but one small group of patients did not. This small group had a higher starting weight than many of the other groups but did not gain any weight across the first 12 sessions. These patients could benefit from a change or increase in the amount or intensity of treatment after the first 12 treatment sessions.

5.
Curr Psychiatry Rep ; 23(8): 52, 2021 07 01.
Article in English | MEDLINE | ID: mdl-34196851

ABSTRACT

PURPOSE OF REVIEW: We are reviewing recent research into the community integration of men convicted of a sexual offence and their (risk) management. This is a high-profile political issue that binds together research in psychology, criminology, politics, health, public health, and policy studies. The review will demonstrate that a multi-disciplinary, life course, EpiCrim-oriented approach is the most effective way of reducing re-offending and promoting desistance in this population. RECENT FINDINGS: Research demonstrates that life course development, especially from psychology and criminology, has an impact on whether people sexually offend or not. Therefore, to understand sexual offending behaviour, we need to look at the aetiology of said behaviour from a nature and a nurture perspective. Therefore, we need to use an Epidemiological Criminology (a marriage of Public Health and criminology) approach that works at all four stages of the Socio-Ecological Model (SEM) (individual, interrelationship, community, and societal). The research encourages a person first approach, that we look at Adverse Childhood Experiences and past trauma in the lives of men who sexually offend and use this, in conjunction with strength-based approaches, to inclusively integrate them into society. The prevention of sexual offending, both first time offending, and relapse prevention require a multi-level, multi-disciplinary approach. Successful desistance from sexual offending is as much about the community and society as it is about the individual.


Subject(s)
Adverse Childhood Experiences , Sex Offenses , Humans , Male , Risk Management , Secondary Prevention , Sex Offenses/prevention & control , Sexual Behavior
6.
Sci Total Environ ; 769: 144804, 2021 May 15.
Article in English | MEDLINE | ID: mdl-33485200

ABSTRACT

Anthelmintics are antiparasitic drugs used to control helminthic parasites such as nematodes and trematodes in animals, particularly those exposed through pasture-based production systems. Even though anthelmintics have been shown to be excreted into the environment in relatively high amounts as unmetabolized drug or transformation products (TPs), there is still only limited information available on their environmental occurrence, particularly in groundwater, which has resulted in them being considered as potential emerging contaminants of concern. A comprehensive study was carried out to investigate the occurrence of 40 anthelmintic residues (including 13 TPs) in groundwaters (and associated surface waters) throughout the Republic of Ireland. The study focused on investigating the occurrence of these contaminants in karst and fractured bedrock aquifers, with a total of 106 sites (88 groundwaters and 18 surface waters) samples during spring 2017. Seventeen anthelmintic compounds consisting of eight parent drugs and nine TPs were detected at 22% of sites at concentrations up to 41 ng L-1. Albendazole and its TPs were most frequently detected residues, found at 8% of groundwater sites and 28% of surface water sites. Multivariate statistical analysis identified several source and pathway factors as being significantly related to the occurrence of anthelmintics in groundwater, however there was an evident localised effect which requires further investigation. An investigation of the temporal variations in occurrence over a 13 month period indicated a higher frequency and concentration of anthelmintics during February/March and again later during August/September 2018, which coincided with periods of increased usage and intensive meteorological events. This work presents the first detections of these contaminants in Irish groundwater and it contributes to broadening our understanding of anthelmintics in the environment. It also provides insight to seasonal trends in occurrence, which is critical for assessing potential future effects and implications of climate change.


Subject(s)
Anthelmintics , Groundwater , Veterinary Drugs , Water Pollutants, Chemical , Animals , Environmental Monitoring , Ireland , Water Pollutants, Chemical/analysis
7.
J Hosp Infect ; 108: 189-196, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33259882

ABSTRACT

BACKGROUND: Understanding how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is spread within the hospital setting is essential in order to protect staff, implement effective infection control measures, and prevent nosocomial transmission. METHODS: The presence of SARS-CoV-2 in the air and on environmental surfaces around hospitalized patients, with and without respiratory symptoms, was investigated. Environmental sampling was undertaken within eight hospitals in England during the first wave of the coronavirus disease 2019 outbreak. Samples were analysed using reverse transcription polymerase chain reaction (PCR) and virus isolation assays. FINDINGS: SARS-CoV-2 RNA was detected on 30 (8.9%) of 336 environmental surfaces. Cycle threshold values ranged from 28.8 to 39.1, equating to 2.2 x 105 to 59 genomic copies/swab. Concomitant bacterial counts were low, suggesting that the cleaning performed by nursing and domestic staff across all eight hospitals was effective. SARS-CoV-2 RNA was detected in four of 55 air samples taken <1 m from four different patients. In all cases, the concentration of viral RNA was low and ranged from <10 to 460 genomic copies/m3 air. Infectious virus was not recovered from any of the PCR-positive samples analysed. CONCLUSIONS: Effective cleaning can reduce the risk of fomite (contact) transmission, but some surface types may facilitate the survival, persistence and/or dispersal of SARS-CoV-2. The presence of low or undetectable concentrations of viral RNA in the air supports current guidance on the use of specific personal protective equipment for aerosol-generating and non-aerosol-generating procedures.


Subject(s)
COVID-19/diagnosis , Disinfection/statistics & numerical data , Health Facilities/statistics & numerical data , SARS-CoV-2/genetics , Aerosols , COVID-19/epidemiology , COVID-19/transmission , COVID-19/virology , Cross Infection/prevention & control , Cross Infection/transmission , Disease Outbreaks/prevention & control , Disinfection/methods , England/epidemiology , Female , Fomites/statistics & numerical data , Fomites/virology , Health Personnel/education , Hospitals/statistics & numerical data , Humans , Infection Control/methods , Male , Personal Protective Equipment/standards , RNA, Viral/genetics , RNA, Viral/isolation & purification , Reverse Transcriptase Polymerase Chain Reaction/methods , SARS-CoV-2/isolation & purification
8.
NPJ Vaccines ; 5: 77, 2020.
Article in English | MEDLINE | ID: mdl-32884842

ABSTRACT

Although traditional egg-based inactivated influenza vaccines can protect against infection, there have been significant efforts to develop improved formats to overcome disadvantages of this platform. Here, we have assessed human CD4 T cell responses to a traditional egg-based influenza vaccine with recently available cell-derived vaccines and recombinant baculovirus-derived vaccines. Adults were administered either egg-derived Fluzone®, mammalian cell-derived Flucelvax® or recombinant HA (Flublok®). CD4 T cell responses to each HA protein were assessed by cytokine EliSpot and intracellular staining assays. The specificity and magnitude of antibody responses were quantified by ELISA and HAI assays. By all criteria, Flublok vaccine exhibited superior performance in eliciting both CD4 T cell responses and HA-specific antibody responses, whether measured by mean response magnitude or percent of responders. Although the mechanism(s) underlying this advantage is not yet clear, it is likely that both qualitative and quantitative features of the vaccines impact the response.

9.
Sci Total Environ ; 744: 140841, 2020 Nov 20.
Article in English | MEDLINE | ID: mdl-32755776

ABSTRACT

North Atlantic European grassland systems have a low nutrient use efficiency and high rainfall. This grassland is typically amended with unprocessed slurry, which counteracts soil organic matter depletion and provides essential plant micronutrients but can be mobilised during rainfall events thereby contributing to pathogen, nutrient and metal incidental losses. Co-digesting slurry with waste from food processing mitigates agriculture-associated environmental impacts but may alter microbial, nutrient and metal profiles and their transmission to watercourses, and/or soil persistence, grass yield and uptake. The impact of EU and alternative pasteurisation regimes on transmission potential of these various pollutants is not clearly understood, particularly in pasture-based agricultural systems. This study utilized simulated rainfall (Amsterdam drip-type) at a high intensity indicative of a worst-case scenario of ~11 mm hr-1 applied to plots 1, 2, 15 and 30 days after grassland application of slurry, unpasteurised digestate, pasteurised digestate (two conditions) and untreated controls. Runoff and soil samples were collected and analysed for a suite of potential pollutants including bacteria, nutrients and metals following rainfall simulation. Grass samples were collected for three months following application to assess yield as well as nutrient and metal uptake. For each environmental parameter tested: microbial, nutrient and metal runoff losses; accumulation in soil and uptake in grass, digestate from anaerobic co-digestion of slurry with food processing waste resulted in lower pollution potential than traditional landspreading of slurry without treatment. Reduced microbial runoff from digestate was the most prominent advantage of digestate application. Pasteurisation of the digestate further augmented those environmental benefits, without impacting grass output. Anaerobic co-digestion of slurry is therefore a multi-beneficial circular approach to reducing impacts of livestock production on the environment.


Subject(s)
Agriculture , Soil , Animals , Cattle , Fertilizers/analysis , Manure , Metals , Nutrients , Poaceae
10.
Sci Total Environ ; 746: 141116, 2020 Dec 01.
Article in English | MEDLINE | ID: mdl-32758987

ABSTRACT

Intensification of the food production system to meet increased global demand for food has led to veterinary pharmaceuticals becoming a critical component in animal husbandry. Anticoccidials are a group of veterinary products used to control coccidiosis in food-producing animals, with primary prophylactic use in poultry production. Excretion in manure and subsequent land-spreading provides a potential pathway to groundwater. Information on the fate and occurrence of these compounds in groundwater is scant, therefore these substances are potential emerging organic contaminants of concern. A study was carried out to investigate the occurrence of anticoccidial compounds in groundwater throughout the Republic of Ireland. Twenty-six anticoccidials (6 ionophores and 20 synthetic anticoccidials) were analysed at 109 sites (63 boreholes and 46 springs) during November and December 2018. Sites were categorised and selected based on the following source and pathway factors: (a) the presence/absence of poultry activity (b) predominant aquifer category and (c) predominant groundwater vulnerability, within the zone of contribution (ZOC) for each site. Seven anticoccidials, including four ionophores (lasalocid, monensin, narasin and salinomycin) and three synthetic anticoccidials (amprolium, diclazuril and nicarbazin), were detected at 24% of sites at concentrations ranging from 1 to 386 ng L-1. Monensin and amprolium were the two most frequently detected compounds, detected at 15% and 7% of sites, respectively. Multivariate statistical analysis has shown that source factors are the most significant drivers of the occurrence of anticoccidials, with no definitive relationships between occurrence and pathway factors. The study found that the detection of anticoccidial compounds is 6.5 times more likely when poultry activity is present within the ZOC of a sampling point, compared to the absence of poultry activity. This work presents the first detections of these contaminants in Irish groundwater and it contributes to broadening our understanding of the environmental occurrence and fate of anticoccidial veterinary products.


Subject(s)
Coccidiostats , Groundwater , Poultry Diseases , Veterinary Drugs , Animals , Chickens , Ireland
11.
Water Res ; 183: 116062, 2020 Sep 15.
Article in English | MEDLINE | ID: mdl-32585388

ABSTRACT

Integrated Constructed Wetlands (ICW) area technology for the attenuation of contaminants such as organic carbon (C), nitrogen (N), phosphorous (P) and sulphur (S) in water coming from point or diffuse sources. Currently there is a lack of knowledge on the rates of gross N transformations in soils of the ICW bed leading to losses of reactive N to the environment. In addition, the kinetics of these processes need to be studied thoroughly for the sustainable use of ICW for removal of excessive N in the treatment of waste waters. Gross N transformation processes were quantified at two soil depths (0-15 and 30-45 cm) in the bed of a surface flow ICW using a 15N tracing approach. The ICW, located in Dunhill village at Waterford in Southeastern Ireland, receives 500 person equivalent waste waters containing large quantities of organic pollutants (ca. mean annual C, N, P and S contents of 240, 60, 5 and 73 mg L-1). Soil was removed from these depths in December 2014 and incubated anaerobically in the laboratory, with either 15N labeled ammonium (NH4+) or nitrate (NO3-), differentially labeled with 14NH415NO3 and 15NH414NO3 in parallel setups, enriched to 50 atm% 15N. Results showed that at both soil depths, NO3- production rates were small, which may have resulted in lower NO3- reduction by either denitrification or dissimilatory NO3- reduction to ammonium (DNRA). However, despite being low, the DNRA rates were greater than denitrification rates. Direct transformation of organic N to NO3-, without mineralization to NH4+, was a prevalent pathway of NO3- production accounting for 28-33% of the total NO3- production. Relative contribution of this process to the total N mineralization was negligible at depth 1 (0.01%) but dominant at depth 2 (99.7%). Total NO3-production to total immobilization of NH4+ and NO3- was very small (<0.50%) suggesting that ICW soils are not a source of NO3-. Despite a large potential of N immobilization existed at both the layers, relative N immobilization to the total N conversion was higher at depth 2 (ca. 2.2) than at depth 1 (ca. 1.5). The NH4+ desorption rate at 30-45 cm was high. However, immobilization in the recalcitrant and labile organic N pools was higher. Mineralization and immobilization of NH4+ processes showed that recalcitrant organic N was the predominant source in ICW soils whereas the labile organic N was comparatively small. Source apportionment of N2O production showed that the majority of the N2O produced through denitrification (ca. 92.5%) followed by heterotrophic nitrification (ca. 5.5%), co-denitrification (ca. 1.90%) and nitrification (0.20%). These results revealed that application of a detailed 15N tracing method can provide insights on the underlying processes of ecosystem based abundances of reactive N. A key finding of this study was that both investigated ICW layers were characterised by large N immobilization which restricts production of NO3- and further gaseous N losses.


Subject(s)
Soil , Wetlands , Denitrification , Ecosystem , Ireland , Nitrates , Nitrogen
12.
Sci Total Environ ; 725: 138329, 2020 Jul 10.
Article in English | MEDLINE | ID: mdl-32278178

ABSTRACT

Nitrogen fertilisation, although a cornerstone of modern agricultural production, negatively impacts the environment through gaseous losses of nitrous oxide (N2O), a potent greenhouse gas (GHG), and ammonia (NH3), a known air pollutant. The aim of this work was to assess the feasibility of urea treated with urease inhibitors to reduce gaseous N losses in temperate grassland, while maintaining or improving productivity compared to conventional fertiliser formulations. Urease inhibitors were N-(n-butyl)-thiophosphoric triamide (NBPT) (urea + NBPT) and N-(n-propyl)-thiophosphoric triamide (NPPT) (urea+ NBPT + NPPT), while conventional fertilisers were urea and calcium ammonium nitrate (CAN). N2O emission factors were 0.06%, 0.07%, 0.09% and 0.58% from urea + NBPT, urea, urea + NBPT + NPPT and CAN, respectively, with CAN significantly higher than all the urea formulations, which were not significantly different from each other. Ammonia loss measured over one fertiliser application was significantly larger from urea, at 43%, compared with other formulations at 13.9%, 13.8% and 5.2% from urea + NBPT, urea + NBPT + NPPT and CAN, respectively. Changing fertiliser formulation had no significant impact on grass yield or N uptake in four out of five harvests. In the last harvest urea + NBPT significantly out-yielded urea, but not CAN or urea + NBPT + NPPT. Overall, urea treated with either one or both urease inhibitors significantly reduced emissions of N2O and NH3, while preserving yield quantity and quality. Therefore, changing fertiliser formulation to these products should be encouraged as a strategy to reduce GHG and air pollution from agricultural practices in temperate climate.

13.
Res Q Exerc Sport ; 91(4): 618-629, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32053466

ABSTRACT

Purpose: The purpose of this study was to compare the workplace experiences of physical education and adapted physical education teachers while also considering biological sex. Role socialization theory was used as a guiding lens. Method: Participants included 653 teachers (women = 382) who taught physical education (n = 420) or adapted physical education (n = 233). Five instruments were used to examine workplace experiences regarding: (a) marginalization and isolation, (b) two elements of perceived mattering, (c) three role stressors, (d) resilience, and (e) emotional exhaustion. Group comparisons were analyzed using a 2 × 2 (discipline x biological sex) factorial MANCOVA while including years of teaching experience as a covariate. Results: No significant interaction effect between teacher group and biological sex was detected; however, there were significant main effects of teacher group, F(9,640) = 19.49, p < .001; Wilk's Λ = .79, partial-η2 = .22, and of biological sex, F(9,640) = 2.81, p < .01; Wilk's Λ = .96, partial-η2 = .04, on the dependent variables. Significant follow-up univariate tests showed that the adapted physical education teachers perceived less marginalization, less isolation, more perceived mattering, and less emotional exhaustion than the physical education teachers. Women from both groups felt significantly more role overload when compared to the men. Conclusion: Collectively, these findings both relate to and extend role socialization theory in explaining how adapted physical education teachers are socialized through the workplace in comparison to their physical education counterparts. Practical implications for preservice and inservice teacher preparation and future research directions are discussed.


Subject(s)
Physical Education and Training , School Teachers/psychology , Socialization , Workplace/psychology , Adult , Burnout, Professional , Female , Humans , Male , Middle Aged , Perception , Resilience, Psychological , Role , Social Isolation , Social Marginalization , Stress, Psychological
14.
J Chromatogr A ; 1618: 460857, 2020 May 10.
Article in English | MEDLINE | ID: mdl-31955842

ABSTRACT

A sensitive and selective method was developed and validated for the determination of 26 anticoccidial compounds (six ionophores and twenty chemical coccidiostats) in surface and groundwater samples at parts-per-quadrillion (pg L-1) to parts-per-trillion (ng L-1) levels by ultra-high performance liquid chromatography with tandem mass spectrometry detection (UHPLC-MS/MS). A range of different analytical columns and mobile phase compositions were evaluated to enhance selectivity and retention of a number of highly polar and basic anticoccidials along with other non-polar coccidiostats. A combined separation, including these problematic polar compounds, was achieved on a phenyl-hexyl column, by binary gradient elution with water/acetonitrile using ammonium formate and formic acid as additives. The anticoccidial residues were extracted from raw, unfiltered, water samples (250 mL) using polymeric divinylbenzene solid phase extraction (SPE) cartridges, with subsequent elution (methanol:acetonitrile:ethyl acetate, 40:40:20, v/v) and concentration prior to determination. The method recovery (at a concentration representative of realistic expected environmental water concentrations based on literature review) ranged from 81% to 105%. The method was successfully validated for 26 anticoccidials, at four concentration levels, in accordance to Commission Decision 2002/657/EC and SANTE/11813/2017 guidelines. Trueness and precision, under within-laboratory reproducibility conditions, ranged from 88% to 111% and 0.9% to 10.3% respectively.


Subject(s)
Chromatography, High Pressure Liquid/methods , Coccidiostats/analysis , Tandem Mass Spectrometry/methods , Water Pollutants, Chemical/analysis , Coccidiostats/isolation & purification , Formates/chemistry , Reproducibility of Results , Solid Phase Extraction , Water Pollutants, Chemical/isolation & purification
15.
Psychol Rep ; 123(6): 2418-2440, 2020 Dec.
Article in English | MEDLINE | ID: mdl-31237827

ABSTRACT

Developing subjective well-being among educational leaders is beneficial for both leaders themselves and students. Evidence has suggested that emotional intelligence has implications for the mental and physical well-being of individuals in leadership positions. This relationship has not, however, been extensively investigated among school administrators, particularly athletic directors, who can influence the lives of student-athletes. Thus, this study sought to examine the relationships among emotional intelligence, job satisfaction, emotional exhaustion, and subjective well-being in high school athletic directors. Participants included 394 U.S. high school athletic directors who completed questionnaires relating to emotional intelligence, job satisfaction, emotional exhaustion, and subjective well-being. The results revealed positive associations between emotional intelligence and subjective well-being and also demonstrated that both job satisfaction and emotional exhaustion mediated the emotional intelligence-subjective well-being relationship. The results highlight the role of emotional intelligence in athletic directors' subjective well-being and suggest that athletic directors should take measures to increase their emotional intelligence through professional learning opportunities and school support structures.


Subject(s)
Emotional Intelligence , Emotions , Job Satisfaction , Schools , Sports/education , Female , Humans , Male , Middle Aged , Surveys and Questionnaires
16.
Adapt Phys Activ Q ; 37(1): 90-111, 2020 01 01.
Article in English | MEDLINE | ID: mdl-31869818

ABSTRACT

Although much has been learned about the workplace experiences of physical education teachers, less is known about the unique experiences of adapted physical educators (APEs). Grounded in role socialization theory, the purpose of this study was to understand the relationships among perceived organizational support, resilience, perceived mattering, emotional exhaustion, and job satisfaction in APEs. The participants included 237 APEs from the United States, who completed an online survey. The primary data analyses included confirmatory factor analysis and structural equation modeling. The final structural model was a good fit for the data, χ2(199) = 327.25, p < .001, χ2/df = 1.64; root-mean-square error of approximation = .052 (90% confidence interval [.042, .062], p = .354); standardized root-mean-square residual = .050; nonnormed fit index = .959; comparative-fit index = .964. The results of this study highlight the importance of developing a workplace environment in which APEs feel supported in developing perceptions of matter, reducing emotional exhaustion, and improving job satisfaction.


Subject(s)
Adaptation, Physiological , Burnout, Professional , Job Satisfaction , Physical Education and Training , Cross-Sectional Studies , Emotions , Factor Analysis, Statistical , Humans , Surveys and Questionnaires , United States , Workplace
17.
Sci Total Environ ; 707: 134606, 2020 Mar 10.
Article in English | MEDLINE | ID: mdl-31877400

ABSTRACT

Increased global demand for dairy produce and the abolition of EU milk quotas have resulted in expansion in dairy production across Europe and particularly in Ireland. Simultaneously, there is increasing pressure to reduce the impact of nitrogen (N) losses to air and groundwater on the environment. In order to develop grassland management strategies for grazing systems that meet environmental targets and are economically sustainable, it is imperative that individual mitigation measures for N efficiency are assessed at farm system level. To this end, we developed an excel-based N flow model simulating an Irish grass-based dairy farm, to evaluate the effect of farm management on N efficiency, N losses, production and economic performance. The model was applied to assess the effect of different strategies to achieve the increased production goals on N utilization, N loss pathways and economic performance at farm level. The three strategies investigated included increased milk production through increased grass production, through increased concentrate feeding and by applying a high profit grass-based system. Additionally, three mitigation measures; low ammonia emission slurry application, the use of urease and nitrification inhibitors and the combination of both were applied to the three strategies. Absolute N emissions were higher for all intensification scenarios (up to 124 kg N ha-1) compared to the baseline (80 kg N ha-1) due to increased animal numbers and higher feed and/or fertiliser inputs. However, some intensification strategies showed the potential to reduce the emissions per ton milk produced for some of the N-loss pathways. The model showed that the assessed mitigation measures can play an important role in ameliorating the increased emissions associated with intensification, but may not be adequate to entirely offset absolute increases. Further improvements in farm N use efficiency and alternatives to mineral fertilisers will be required to decouple production from reactive N emissions.


Subject(s)
Dairying , Animals , Europe , Ireland , Milk , Nitrogen
18.
Adapt Phys Activ Q ; 36(4): 472-491, 2019 10 01.
Article in English | MEDLINE | ID: mdl-31491750

ABSTRACT

Occupational socialization theory has been used to understand the recruitment, education, and socialization of physical education teachers for nearly 40 yr. It has, however, only recently been applied to the study of adapted physical education teachers. The purpose of this descriptive case study was to understand the socialization of preservice teachers in an adapted physical education teacher education graduate-level program. Participants included 17 purposefully selected preservice teachers (5 male and 12 female) enrolled in a yearlong graduate-level adapted physical education teacher education program. Qualitative data were collected using interviews, reflective journaling, and field notes taken during teaching and coursework observations. Data analysis resulted in the construction of 3 themes: overcoming contextual challenges to meet learners' needs, the importance of field-based teacher education, and coping with the challenges of marginalization. The discussion connects to and advances occupational socialization theory in adapted physical education and suggests that professional socialization may have a more profound influence on preservice adapted physical education teachers than on their physical education counterparts.


Subject(s)
Physical Education and Training , Socialization , Teacher Training , Adult , Female , Humans , Interviews as Topic , Male , Qualitative Research , Social Marginalization , Young Adult
19.
Res Q Exerc Sport ; 90(4): 699-711, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31469344

ABSTRACT

Purpose: A paucity of literature examines how doctoral students are prepared for the transition into physical education teacher education faculty roles. Given the need to understand how doctoral programs impact such preparation, we sought to investigate this process using a longitudinal approach grounded in occupational socialization theory. Method: Fourteen participants (8 males, 6 female) were interviewed during final stages of doctoral programs and their first years in faculty positions; questions focused on key socializing agents and experiences that shaped their preparation for their academic careers. Data were analyzed using a constant comparison approach entailing open and axial coding. Results: Strong advisor-advisee relationships and finding a supportive department culture during one's first faculty position were key socializing mechanisms. Participants who independently sought research experiences transitioned more smoothly into faculty roles; however, many had heavy teaching loads which conflicted with ambitions to regularly conduct research. Further, some faculty members experienced tense sociopolitical environments which hindered their productivity and confidence in current job roles. Conclusions: Our results speak to the challenges and successes that faculty members experience as they transition into the academy. Findings have implications for further research and practice to enhance the quality of doctoral education and faculty induction programs.


Subject(s)
Faculty/psychology , Physical Education and Training , Socialization , Students/psychology , Adult , Female , Humans , Interdisciplinary Placement , Longitudinal Studies , Male , Research , Teaching/psychology
20.
Am J Audiol ; 28(3): 617-627, 2019 Sep 13.
Article in English | MEDLINE | ID: mdl-31268727

ABSTRACT

Newborn hearing screening (NBHS) has become the norm in all states in the United States. However, parents receive limited information about it, usually at the hospital, and have low awareness about the process. Yet parents and professionals agree that communication about the NBHS process should begin before childbirth (Arnold et al., 2006). Having information about the screening process, simply by being present for the screening and knowing the results, has been shown to positively affect parental attitudes toward NBHS (Weichbold, Welzl-Mueller, & Mussbacher, 2001). Purpose The aim of this study was to assess whether providing expectant mothers with information related to the NBHS process in the 3rd trimester will increase their satisfaction with the NBHS program. Method Partnering with a local obstetrician, expectant mothers were provided with information regarding NBHS. A modified version of the Parent Satisfaction Questionnaire with Neonatal Hearing Screening Program (Mazlan, Hickson, & Driscoll, 2006) was administered to mothers who received information and mothers who did not receive any education. Results Quantitative results indicate significantly increased satisfaction with the NBHS program when early education was received. Qualitative comments from participants support the quantitative findings. Conclusion Results suggest that educating obstetricians and their nurses about NBHS and having them provide information to expectant mothers, as well as having mothers present for the screening, may increase parental satisfaction and therefore benefit early hearing detection and intervention programs.


Subject(s)
Hearing Loss/diagnosis , Mothers/education , Neonatal Screening/methods , Patient Education as Topic , Patient Satisfaction , Adolescent , Adult , Early Diagnosis , Female , Humans , Infant, Newborn , Otoacoustic Emissions, Spontaneous , Pamphlets , Pregnancy , Pregnancy Trimester, Third , Prenatal Care , Surveys and Questionnaires , Young Adult
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