ABSTRACT
This cohort study examines the association between methotrexate use and interstitial lung disease in patients with dermatomyositis.
Subject(s)
Dermatomyositis , Lung Diseases, Interstitial , Methotrexate , Humans , Dermatomyositis/drug therapy , Dermatomyositis/chemically induced , Dermatomyositis/diagnosis , Lung Diseases, Interstitial/chemically induced , Lung Diseases, Interstitial/diagnosis , Lung Diseases, Interstitial/drug therapy , Methotrexate/adverse effects , Methotrexate/administration & dosage , Female , Middle Aged , Male , Adult , Dermatologic Agents/adverse effects , Dermatologic Agents/administration & dosage , Risk Factors , AgedABSTRACT
This cohort study describes the clinical features, patient characteristics, and treatment of anti-melanoma differentiationassociated gene 5 (MDA5) dermatomyositis.
Subject(s)
Continuity of Patient Care , Dermatomyositis , Hospitalization , Interferon-Induced Helicase, IFIH1 , Humans , Dermatomyositis/immunology , Dermatomyositis/drug therapy , Dermatomyositis/therapy , Interferon-Induced Helicase, IFIH1/immunology , Hospitalization/statistics & numerical data , Female , Continuity of Patient Care/organization & administration , Male , Middle Aged , Adult , Autoantibodies/blood , Autoantibodies/immunologySubject(s)
Dermatitis , Population Health , Scleroderma, Localized , Adult , Humans , Scleroderma, Localized/epidemiology , Skin , ComorbidityABSTRACT
This cohort study characterizes the presentation, causes, treatment, and disease course of erythema nodosum, as well as identifies associations with chronicity and recurrence.
Subject(s)
Erythema Nodosum , Humans , Erythema Nodosum/diagnosis , Erythema Nodosum/complications , RecurrenceABSTRACT
An 83-year-old male with a history of both melanoma and non-melanoma skin cancers presented with a light pink non-ulcerated slightly raised 0.6 × 0.5-cm papule on his left lower extremity. Biopsy specimen revealed a proliferation of intraepidermal round blue cells. On immunohistochemical staining, CD56, chromogranin, and pancytokeratin were faintly positive within the lesional population, while synaptophysin was strongly positive. CD45, CK5/6, CK7, CK20, Melan-A, SOX10, and TTF-1 stains were negative. There was no dermal component identified. A Merkel cell polyomavirus stain was negative. Distant metastases and other in situ pathologies were excluded and a diagnosis of Merkel cell carcinoma in situ (MMCIS) was made. The majority of MCCIS lesions reported in the literature have been discovered amongst other non-melanoma neoplasms. Our findings of an MCCIS with purely intraepidermal involvements without the association with another squamous cell neoplasm is rare finding.
