ABSTRACT
Background: Assessment of kidney function in emergency settings is essential across all medical subspecialties. Daily assessment of patient creatinine results from emergency medical services showed that some deviated from expected values, implying drug-related interference. Methods: Real-time clinical evaluation of an enzyme method (Roche CREP2) in comparison with the Jaffé gen. 2 method (Roche CREJ2) was performed. During the period of December 2022 and January 2023, we analyzed 8,498 patient samples, where 5,524 were heavily medicated STAT patient specimens, 500 were pediatric specimens, and 2,474 were from a distant general population in a different region using the same methods. Results: In 109 out of 5,524 hospital specimens (1.97%, p < 0.001), the CREP2 value was apparently (25% or more) lower than CREJ2. Suspect interfering medication was found in a sample of 43 out of 46 reviewed patients where medication data were available. This phenomenon was not observed in the general population. Conclusion: In a polymedicated urgent care hospital population, a creatinine enzyme method produces unreliable results, apparently due to multiple drug-related interferences.
ABSTRACT
The passage and specific gravity of nylon capsules were evaluated in five trials. In individual trials, different lactating cows were fed the same diet consisting of maize silage, alfalfa hay and concentrate. In each trial the different feeds (or no feed) were used to fill the capsules. The capsules were made of nylon cloth (42 microm pore size, 10 mm external diameter). The different weights of the load (L1-L5) were obtained using a combination of 2 and 3 mm stainless steel balls. The highest recovery of the capsules was obtained with the L3 and L4 loads (91.4 and 92.3%, resp.). After 14 hours of incubation in the rumen, the calculated values of functional specific gravity of the capsules ranged from 0.92 to 2.05 g x cm(-3). It was concluded that L3 (one 2 mm and one 3 mm ball) was the suitable weight of the load.
