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Euro Surveill ; 19(30)2014 Jul 31.
Article in English | MEDLINE | ID: mdl-25108533

ABSTRACT

We describe four cases in Sweden of verified treatment failures of pharyngeal gonorrhoea with ceftriaxone (500 mg; n=3) or cefotaxime (500 mg; n=1) monotherapy. All the ceftriaxone treatment failures were caused by the internationally spreading multidrug-resistant gonococcal NG-MAST genogroup 1407 clone. Increased awareness of treatment failures is crucial particularly when antimicrobial monotherapy is used. Frequent test of cure and appropriate verification/falsification of suspected treatment failures, as well as implementation of recommended dual antimicrobial therapy are imperative.


Subject(s)
Ceftriaxone/therapeutic use , Gonorrhea/drug therapy , Neisseria gonorrhoeae/drug effects , Neisseria gonorrhoeae/isolation & purification , Pharyngeal Diseases/drug therapy , Adult , Anti-Bacterial Agents/therapeutic use , Dose-Response Relationship, Drug , Drug Resistance, Bacterial , Female , Gonorrhea/diagnosis , Gonorrhea/microbiology , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Neisseria gonorrhoeae/genetics , Pharyngeal Diseases/diagnosis , Pharyngeal Diseases/microbiology , Polymerase Chain Reaction , Sweden , Treatment Failure
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