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1.
Aust Vet J ; 97(9): 357-360, 2019 Sep.
Article in English | MEDLINE | ID: mdl-31286481

ABSTRACT

An adult female Eastern Grey kangaroo (Macropus giganteus) was examined for lameness due to a mass located at the right tibiotarsal joint. Radiographs revealed a metal arrowhead-shaped foreign body within the mass alongside a pathologic fracture. Grossly, at necropsy, there was a multilobulated and haemorrhagic mass with intralesional metal fragments, associated osteolysis of the tibiotarsus and pulmonary metastatic nodules. Histologically the neoplasm was composed of plump elongated and fusiform cells that often formed concentrically around small vessels. The pulmonary nodules were composed of similar neoplastic cells, necrosis and haemorrhage. Neoplastic cells were positive immunohistochemically for vimentin and smooth muscle actin. The histological features, immunohistochemical profiles and behaviour of this tumour support a diagnosis of a primary angioleiomyosarcoma with lung metastasis associated with a metal foreign body.


Subject(s)
Angiomyoma/veterinary , Foreign Bodies/veterinary , Leiomyosarcoma/veterinary , Macropodidae , Angiomyoma/etiology , Angiomyoma/pathology , Animals , Autopsy/veterinary , Female , Foreign Bodies/complications , Lameness, Animal/etiology , Leiomyosarcoma/etiology , Leiomyosarcoma/pathology , Lung Neoplasms/pathology , Lung Neoplasms/secondary , Lung Neoplasms/veterinary , New South Wales , Osteolysis/etiology , Osteolysis/pathology , Osteolysis/veterinary , Tibia/pathology
2.
Vet Pathol ; 46(3): 449-52, 2009 May.
Article in English | MEDLINE | ID: mdl-19176509

ABSTRACT

Thymic cysts with pseudoepitheliomatous hyperplasia are described in a 7-month-old female American Eskimo Dog that died of complications from brodifacoum poisoning. Grossly, there was hemothorax with marked cranial mediastinal hemorrhage. Histologically, thymic lobules were expanded and distorted by irregular cysts, lined by single to multiple layers of plump to slightly attenuated polygonal squamous epithelial cells supported by a basement membrane (pseudoepitheliomatous hyperplasia). The thymus had a paucity of lymphocytes and lacked corticomedullary differentiation. Extensive hemorrhage within the cysts and thymic parenchyma extended into the adjacent adipose tissue. To the authors' knowledge, this is the first report of cystic thymic degeneration with pseudoepitheliomatous hyperplasia in a nonhuman species.


Subject(s)
4-Hydroxycoumarins/poisoning , Dog Diseases/chemically induced , Hyperplasia/veterinary , Rodenticides/poisoning , Thymus Gland/pathology , Animals , Dog Diseases/pathology , Dogs , Epithelium/pathology , Female , Hyperplasia/pathology , Thymus Gland/drug effects
3.
Vet Pathol ; 38(6): 710-1, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11732806

ABSTRACT

In each of seven ferrets (Mustela putorius furo) with leiomyosarcoma, a single dermal mass was identified and biopsied. Each mass consisted of a well-demarcated but nonencapsulated proliferation of large spindle- to strap-shaped cells arranged in interwoven bundles. The cells resembled the smooth muscle cells of the adjacent arrector pili muscles, but with marked nuclear pleomorphism. Immunohistochemical staining for smooth muscle actin, desmin, and vimentin was positive and staining for myoglobin and cytokeratin was negative. Follow-up on three of the ferrets indicates that the prognosis is good following complete surgical excision.


Subject(s)
Ferrets , Leiomyosarcoma/pathology , Leiomyosarcoma/veterinary , Muscle Neoplasms/pathology , Muscle Neoplasms/veterinary , Animals , Female , Immunohistochemistry/veterinary , Leiomyosarcoma/surgery , Male , Muscle Neoplasms/surgery
4.
Chemistry ; 6(2): 216-24, 2000 Jan.
Article in English | MEDLINE | ID: mdl-11931101

ABSTRACT

A nonempirical exciton chirality circular dichroic (CD) method for determining the absolute configurations of primary monoamines with amino group directly linked to the stereogenic center is described. Conventional exciton chirality CD method cannot be applied to these compounds since they lack the two sites for attaching the interacting chromophores. This was solved by covalently linking the monoamine to a trifunctional bidentate carrier moiety 1. Treatment of the carrier/monoamine conjugate with the porphyrin tweezer 4 consisting of two pentanediol-linked zinc porphyrins gives rise to 1:1 host-guest macrocyclic complexes that exhibit exciton-coupled CD spectra. The sign of the CD couplet can then be correlated with the absolute configuration of the monoamine as follows: a clockwise arrangement of the L, M, and S (large, medium, small) groups in the Newman projection of the monoamine with the amino group in the rear gives rise to a positive CD couplet, and vice versa; the assignments of L, M, S groups are based on conformational energies (A values). This method is applicable to cyclic and acyclic aliphatic amines, aromatic amines, amino esters, amides, and cyclic amino alcohols, and can be performed at the several microgram level.


Subject(s)
Metalloporphyrins/chemistry , Amines/chemistry , Circular Dichroism , Molecular Structure , Stereoisomerism
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