ABSTRACT
Galectin-3 (gal-3) is a ß-galactoside binding protein present in multivalent complexes with an extracellular matrix and with cell surface glycoconjugates. In this context, it can deliver a variety of intracellular signals to modulate cell activation, differentiation and survival. In the hematopoietic system, it was demonstrated that gal-3 is expressed in myeloid cells and surrounding stromal cells. Furthermore, exogenous and surface gal-3 drive the proliferation of myeloblasts in a granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent manner. Here, we investigated whether gal-3 regulates the formation of myeloid bone marrow compartments by studying galectin-3(-/-) mice (gal-3(-/-)) in the C57BL/6 background. The bone marrow histology of gal-3(-/-) mice was significantly modified and the myeloid compartments drastically disturbed, in comparison with wild-type (WT) animals. In the absence of gal-3, we found reduced cell density and diaphyseal disorders containing increased trabecular projections into the marrow cavity. Moreover, myeloid cells presented limited capacity to differentiate into mature myeloid cell populations in gal-3(-/-) mice and the number of hematopoietic multipotent progenitors was increased relative to WT animals. In addition, bone marrow stromal cells of these mice had reduced levels of GM-CSF gene expression. Taken together, our data suggest that gal-3 interferes with hematopoiesis, controlling both precursors and stromal cells and favors terminal differentiation of myeloid progenitors rather than proliferation.
Subject(s)
Bone Marrow Cells/cytology , Bone Marrow Cells/metabolism , Galectin 3/deficiency , Animals , Cell Differentiation , Galectin 3/genetics , Galectin 3/metabolism , Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology , Hematopoietic Stem Cells/cytology , Hematopoietic Stem Cells/metabolism , Inbreeding , Mice , Mice, Inbred C57BL , Mice, Knockout , Stromal Cells/cytology , Stromal Cells/metabolismABSTRACT
To get acquainted with the information handled by health There are many psychic phenomena that may be observed both among diagnosticated patients and among persons included in the statistical media of normality. Reality as continuum, perception and some particular forms of it (pareidolias, sensitive pseudo-images, hipnogogical and hipnopompical hallucinations, eidetic images, sensitive post-images, dej racont, cout, vu, etc.) as well as premonitions, epiphanies, mystical experiences and overvalued, delirious, encapsulated, fixed ideas, would be characteristic of mental state depending on their intensity and their place in the psychic life. These events are assessed according society and the general circumstances in each situation, and they are presented seperately only by classificatory interest.
Subject(s)
Activities of Daily Living/psychology , Mental Disorders/psychology , HumansABSTRACT
To get acquainted with the information handled by health There are many psychic phenomena that may be observed both among diagnosticated patients and among persons included in the statistical media of normality. Reality as continuum, perception and some particular forms of it (pareidolias, sensitive pseudo-images, hipnogogical and hipnopompical hallucinations, eidetic images, sensitive post-images, dej racont, cout, vu, etc.) as well as premonitions, epiphanies, mystical experiences and overvalued, delirious, encapsulated, fixed ideas, would be characteristic of mental state depending on their intensity and their place in the psychic life. These events are assessed according society and the general circumstances in each situation, and they are presented seperately only by classificatory interest.
ABSTRACT
To get acquainted with the information handled by health There are many psychic phenomena that may be observed both among diagnosticated patients and among persons included in the statistical media of normality. Reality as continuum, perception and some particular forms of it (pareidolias, sensitive pseudo-images, hipnogogical and hipnopompical hallucinations, eidetic images, sensitive post-images, dej racont, cout, vu, etc.) as well as premonitions, epiphanies, mystical experiences and overvalued, delirious, encapsulated, fixed ideas, would be characteristic of mental state depending on their intensity and their place in the psychic life. These events are assessed according society and the general circumstances in each situation, and they are presented seperately only by classificatory interest.
ABSTRACT
On the basis of the pathology described by Lasègue & Falret, this papers intends to further a psychoanalytic distinction between both types of psychosis which exemplify 'folie à deux'. Hypothesis are proposed which refer to the difference in the psychic structure, in view of the 'body into pieces' experience in Type I delirium cases and a mainly neurotic organization in Type II delirium cases. A case in brought up where part of the interview reveals the rigid as well as sealed bond organization between significant and meaning. Reference is also made to the qualities of symbiotic attachment between both partners in the delirious intercourse, and to the importance the consideration of this diagnostic difference has with regards to the therapeutic strategy.
Subject(s)
Shared Paranoid Disorder/psychology , Adult , Aged , Delirium/psychology , Female , Humans , Psychoanalysis , Psychoanalytic Theory , Shared Paranoid Disorder/therapyABSTRACT
On the basis of the pathology described by LasÞgue & Falret, this papers intends to further a psychoanalytic distinction between both types of psychosis which exemplify folie O deux. Hypothesis are proposed which refer to the difference in the psychic structure, in view of the body into pieces experience in Type I delirium cases and a mainly neurotic organization in Type II delirium cases. A case in brought up where part of the interview reveals the rigid as well as sealed bond organization between significant and meaning. Reference is also made to the qualities of symbiotic attachment between both partners in the delirious intercourse, and to the importance the consideration of this diagnostic difference has with regards to the therapeutic strategy.
ABSTRACT
It is essential to have a concept of psychosis, based on a psychoanalitic pattern of the functioning of mental life. A dynamic differential diagnosis of the different types of psychosis should be done. Speaking about "the" transference in "the" psychosis leads to confusions that render inoperative the theories and techniques used in the treatment of the psychotic structures. Considering the transferences as an unattainable part of reality that keeps on passing from one structure to another, it has different features in the different types of psychosis. In a broad sense it is also present in all the forms of relationships of human beings. It is the essential factor of a communicational style.
Subject(s)
Psychotic Disorders/therapy , Transference, Psychology , Diagnosis, Differential , Humans , Psychotic Disorders/diagnosisABSTRACT
It is essential to have a concept of psychosis, based on a psychoanalitic pattern of the functioning of mental life. A dynamic differential diagnosis of the different types of psychosis should be done. Speaking about [quot ]the[quot ] transference in [quot ]the[quot ] psychosis leads to confusions that render inoperative the theories and techniques used in the treatment of the psychotic structures. Considering the transferences as an unattainable part of reality that keeps on passing from one structure to another, it has different features in the different types of psychosis. In a broad sense it is also present in all the forms of relationships of human beings. It is the essential factor of a communicational style.
ABSTRACT
1. Es indispensable tener un concepto de psicosis basado en un modelo psicoanalitico del funcionamiento del psiquico. 2. Debe hacerse un diagnostico diferencial dinamico de los distintos tipos de psicosis.3. Hablar de "la" transferencia en "la" psicosis lleva a confusiones que hacen inoperantes las teorias y las tecnicas que se utilizan en el tratamiento de los cuadros psicoticos. 3. La transferencia tomada como una parte inasible de la realidad que va pasando de una estructura a otra, tiene diferentes caracteristicas en los distintos tipos de psicosis. Tomada en un sentido amplio esta tambien presente en la modalidad relacional de los humanos. Es lo esencial de un estilo comunicacional
Subject(s)
Humans , Psychotic Disorders , Transfer, PsychologyABSTRACT
1. Es indispensable tener un concepto de psicosis basado en un modelo psicoanalitico del funcionamiento del psiquico. 2. Debe hacerse un diagnostico diferencial dinamico de los distintos tipos de psicosis.3. Hablar de "la" transferencia en "la" psicosis lleva a confusiones que hacen inoperantes las teorias y las tecnicas que se utilizan en el tratamiento de los cuadros psicoticos. 3. La transferencia tomada como una parte inasible de la realidad que va pasando de una estructura a otra, tiene diferentes caracteristicas en los distintos tipos de psicosis. Tomada en un sentido amplio esta tambien presente en la modalidad relacional de los humanos. Es lo esencial de un estilo comunicacional
