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2.
Hematol., Transfus. Cell Ther. (Impr.) ; 44(4): 549-554, Oct.-dec. 2022. tab, ilus
Article in English | LILACS | ID: biblio-1421524

ABSTRACT

ABSTRACT Objective: The objective of this study was to evaluate the oral health condition and dental treatments performed in patients in pre-allogeneic HCT. Method: The records of patients treated during 2018 at a Brazilian HCT service were reviewed. The following oral health data were obtained: 1. Decayed, missing and filled teeth / correlated index for primary dentition (DMFT/dmft); 2. Quality of oral hygiene and 3. Dental pathologies: 3.1 Periodontal infectious focus, 3.2 Endodontic infectious focus and 3.3 Carie incidence. All dental procedures performed were surveyed. Results: Thirty-three patients were included, with a mean age of 28.42 (±16.37), 20 male (60%) and 13 female. The average DMFT/dmft found in this study was 10.24 (± 8.37), similar to the index found in the population in southeastern Brazil. The younger study population presented a DMFT/dmft considered high, when compared to the general population. A total of 27.2% of the patients had active caries lesions, 33.3%, foci of periodontal infection, 15.1%, endodontic infectious focus and 40%, poor oral hygiene. Almost half of the patients (48.4%) had to undergo dental intervention, 24.2% needing periodontal scaling, 21.2%, fillings and 12.1%, tooth extractions. Conclusion: We conclude that the studied population had an important incidence of dental pathologies and infectious conditions that could complicate throughout HCT, especially in younger patients, therefore presenting a high demand for dental treatment in the pre-HCT. Studies that assess the impact of dental conditioning on the outcomes of HCT with an emphasis on dental infectious complications, days of hospitalization and survival are necessary."


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Young Adult , Oral Health , Hematopoietic Stem Cell Transplantation , Transplantation, Homologous , Bone Marrow Transplantation , Focal Infection
5.
Hematol Transfus Cell Ther ; 44(4): 549-554, 2022.
Article in English | MEDLINE | ID: mdl-34090846

ABSTRACT

INTRODUCTION: The optimization of oral health before allogeneic hematopoietic cell transplantation (HCT) is important for preventing infectious complications during treatment. OBJECTIVE: The objective of this study was to evaluate the oral health condition and dental treatments performed in patients in pre-allogeneic HCT. METHOD: The records of patients treated during 2018 at a Brazilian HCT service were reviewed. The following oral health data were obtained: 1. Decayed, missing and filled teeth / correlated index for primary dentition (DMFT/dmft); 2. Quality of oral hygiene and 3. Dental pathologies: 3.1 Periodontal infectious focus, 3.2 Endodontic infectious focus and 3.3 Carie incidence. All dental procedures performed were surveyed. RESULTS: Thirty-three patients were included, with a mean age of 28.42 (±16.37), 20 male (60%) and 13 female. The average DMFT/dmft found in this study was 10.24 (± 8.37), similar to the index found in the population in southeastern Brazil. The younger study population presented a DMFT/dmft considered high, when compared to the general population. A total of 27.2% of the patients had active caries lesions, 33.3%, foci of periodontal infection, 15.1%, endodontic infectious focus and 40%, poor oral hygiene. Almost half of the patients (48.4%) had to undergo dental intervention, 24.2% needing periodontal scaling, 21.2%, fillings and 12.1%, tooth extractions. CONCLUSION: We conclude that the studied population had an important incidence of dental pathologies and infectious conditions that could complicate throughout HCT, especially in younger patients, therefore presenting a high demand for dental treatment in the pre-HCT. Studies that assess the impact of dental conditioning on the outcomes of HCT with an emphasis on dental infectious complications, days of hospitalization and survival are necessary."

6.
Support Care Cancer ; 29(1): 127-134, 2021 Jan.
Article in English | MEDLINE | ID: mdl-32318870

ABSTRACT

PURPOSE: The aim of this study was to evaluate the distribution of acute clinical complications that involve the oral cavity (oral mucositis and salivary flow), general health status (Karnofsky performance status scale (KPS) and weight), and quality of life using the worst performance throughout radiotherapy treatment by intensity-modulated radiation therapy (IMRT) in the head and neck region and to evaluate the correlation between these variables. METHODS: This prospective, longitudinal study evaluated 32 patients who were undergoing IMRT for head and neck tumors. The measures were collected weekly through standardized protocols and a quality of life questionnaire (UW-QOL version 4). RESULTS: The worst performance for all variables was concentrated in treatment weeks 2 and 5. Regarding quality of life, the emotional dimensions were the most affected (pain 62.86; activity 55; recreation 43.57; mood 49.97; shoulder 57.06; anxiety 42.91). There were a higher number of moderate mucositis correlations with quality of life (mucositis × KPS 0.002; mucositis × weight loss 0.03; mucositis × pain 0.001; mucositis × activity 0.002; mucositis × recreation 0.001; mucositis × swallowing 0.002; mucositis × saliva 0.006; mucositis × mood 0.007; mucositis × anxiety 0.002). CONCLUSIONS: IMRT treatment severely deteriorated the patients' quality of life. There were important correlations between the clinical variables and quality of life, especially mucositis.


Subject(s)
Head and Neck Neoplasms/radiotherapy , Mouth Mucosa/pathology , Radiotherapy, Intensity-Modulated/adverse effects , Salivary Glands/pathology , Stomatitis/etiology , Xerostomia/pathology , Adult , Aged , Female , Humans , Karnofsky Performance Status , Longitudinal Studies , Male , Middle Aged , Prospective Studies , Quality of Life/psychology , Surveys and Questionnaires
9.
Int. arch. otorhinolaryngol. (Impr.) ; 23(3): 299-304, July-Sept. 2019. tab, graf
Article in English | LILACS | ID: biblio-1040025

ABSTRACT

Abstract Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/epidemiology , Laryngeal Neoplasms/epidemiology , Prognosis , Tobacco Use Disorder , Brazil , Alcohol Drinking , Survival Analysis , Epidemiology, Descriptive , Retrospective Studies , Risk Factors , Tertiary Care Centers
10.
Int Arch Otorhinolaryngol ; 23(3): e299-e304, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31360249

ABSTRACT

Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS ( p = 0.02) and OS ( p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients ( p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 ( p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients ( p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.

11.
Rev. bras. odontol ; 76(1): 1-7, jan. 2019. ilust, tab
Article in English | LILACS | ID: biblio-1119631

ABSTRACT

Objetivo: O objetivo desse estudo foi avaliar a eficácia do diagnóstico e tratamento de lesões orais entre diferentes níveis de saúde. Material e Métodos: Todas as informações foram obtidas dos prontuários médicos de um Hospital Universitário e de fichas do Sistema Público de Regulação, considerando as características clínico-demográficas tal como, doenças orais diagnosticadas, sistema de referência e terapia empregada. A avaliação foi baseada na relação entre diagnóstico final, hipótese diagnóstica e prioridade para agendamento da consulta, também foi considerado o tempo decorrido entre o encaminhamento e o primeiro atendimento, data do diagnóstico final e início da terapia. Depois, a hipótese diagnóstica preenchida por profissionais de saúde do nível primário e terciário foram comparadas e a concordância entre ambos foi determinada. Resultados: Cerca de 51% dos encaminhamentos preenchidos pelos profissionais da atenção primária estavam incompletos, ou a hipótese diagnóstica estava descrita de forma inadequada. No nível terciário, o tempo médio entre o encaminhamento e a primeira consulta foi de 23 dias, a média entre o diagnóstico final e o início do tratamento foi de 22 dias. O tratamento cirúrgico foi o mais rápido (31 dias) quando comparado a radioterapia para lesões malignas (81 a 100 dias). Conclusão: É necessário melhorar o treinamento de profissionais de saúde da Atenção Básica no reconhecimento de lesões orais malignas. Claramente, o preenchimento adequado das hipóteses de diagnóstico, com o grau de prioridade correspondente acelera o diagnóstico e tratamento do paciente.


Objective: this study aims to evaluate the efficacy of diagnosis and treatment of oral lesions between different healthcare levels. Material and Methods: all information was obtained from the medical records of a University Hospital and Public Health Regulation System regarding clinical-demographic features such as oral diseases diagnosed, referral system and therapy employed. Evaluation was based on the relationship between final diagnosis, diagnostic hypothesis and the priority of medical appointments, time between referral and first appointment, date of final diagnosis and therapy onset. Latter, diagnostic hypothesis fulfilled between primary and tertiary healthcare providers were compared and the agreement between both were determined. Results: about half (51%) of the medical forms filled by primary healthcare professionals were incomplete, or diagnostic hypothesis was inadequately described. At the tertiary healthcare level, mean time between referral and first appointment was 23 days, and mean time between the final diagnosis and treatment was 22 days. Surgical treatment was faster (31 days) when compared to radiotherapy for malignant lesions (81 to 100 days). Conclusion: it is necessary to improve training of healthcare professionals in the primary healthcare regarding the recognition of malignant oral lesions. Clearly, appropriate filling of the diagnostic hypothesis with the corresponding degree of priority accelerates the diagnosis and treatment of the patient.


Subject(s)
Humans , Mouth Neoplasms , Health Personnel , Diagnosis, Oral , Mouth Diseases
12.
Arq Gastroenterol ; 55(1): 50-54, 2018.
Article in English | MEDLINE | ID: mdl-29561977

ABSTRACT

BACKGROUND: Dysphagia is described as a complaint in 32% of patients with laryngitis. OBJECTIVE: The objective of this investigation was to evaluate oral and pharyngeal transit of patients with laryngitis, with the hypothesis that alteration in oral-pharyngeal bolus transit may be involved with dysphagia. METHODS: Videofluoroscopic evaluation of the swallowing of liquid, paste and solid boluses was performed in 21 patients with laryngitis, 10 of them with dysphagia, and 21 normal volunteers of the same age and sex. Two swallows of 5 mL liquid bolus, two swallows of 5 mL paste bolus and two swallows of a solid bolus were evaluated in a random sequence. The liquid bolus was 100% liquid barium sulfate and the paste bolus was prepared with 50 mL of liquid barium and 4 g of food thickener (starch and maltodextrin). The solid bolus was a soft 2.2 g cookie coated with liquid barium. Durations of oral preparation, oral transit, pharyngeal transit, pharyngeal clearance, upper esophageal sphincter opening, hyoid movement and oral-pharyngeal transit were measured. All patients performed 24-hour distal esophageal pH evaluation previous to videofluoroscopy. RESULTS: The evaluation of 24-hour distal esophageal pH showed abnormal gastroesophageal acid reflux in 10 patients. Patients showed longer oral preparation for paste bolus and a faster oral transit time for solid bolus than normal volunteers. Patients with laryngitis and dysphagia had longer preparation for paste and solid boluses, and a faster oral transit time with liquid, paste and solid boluses. CONCLUSION: A longer oral preparation for paste and solid boluses and a faster transit through the mouth are associated with dysphagia in patients with laryngitis.


Subject(s)
Deglutition Disorders/physiopathology , Deglutition/physiology , Laryngitis/physiopathology , Adult , Aged , Barium , Case-Control Studies , Deglutition Disorders/diagnostic imaging , Deglutition Disorders/etiology , Female , Fluoroscopy/methods , Food Additives/administration & dosage , Gastroesophageal Reflux/etiology , Humans , Laryngitis/complications , Laryngitis/diagnostic imaging , Laryngoscopy , Male , Middle Aged
13.
Arq. gastroenterol ; 55(1): 50-54, Apr.-Mar. 2018. tab, graf
Article in English | LILACS | ID: biblio-888238

ABSTRACT

ABSTRACT BACKGROUND: Dysphagia is described as a complaint in 32% of patients with laryngitis. OBJECTIVE: The objective of this investigation was to evaluate oral and pharyngeal transit of patients with laryngitis, with the hypothesis that alteration in oral-pharyngeal bolus transit may be involved with dysphagia. METHODS: Videofluoroscopic evaluation of the swallowing of liquid, paste and solid boluses was performed in 21 patients with laryngitis, 10 of them with dysphagia, and 21 normal volunteers of the same age and sex. Two swallows of 5 mL liquid bolus, two swallows of 5 mL paste bolus and two swallows of a solid bolus were evaluated in a random sequence. The liquid bolus was 100% liquid barium sulfate and the paste bolus was prepared with 50 mL of liquid barium and 4 g of food thickener (starch and maltodextrin). The solid bolus was a soft 2.2 g cookie coated with liquid barium. Durations of oral preparation, oral transit, pharyngeal transit, pharyngeal clearance, upper esophageal sphincter opening, hyoid movement and oral-pharyngeal transit were measured. All patients performed 24-hour distal esophageal pH evaluation previous to videofluoroscopy. RESULTS: The evaluation of 24-hour distal esophageal pH showed abnormal gastroesophageal acid reflux in 10 patients. Patients showed longer oral preparation for paste bolus and a faster oral transit time for solid bolus than normal volunteers. Patients with laryngitis and dysphagia had longer preparation for paste and solid boluses, and a faster oral transit time with liquid, paste and solid boluses. CONCLUSION: A longer oral preparation for paste and solid boluses and a faster transit through the mouth are associated with dysphagia in patients with laryngitis.


RESUMO CONTEXTO: Disfagia é uma queixa presente em 32% dos pacientes com laringite. OBJETIVO: O objetivo desta investigação foi avaliar o trânsito oral e faríngeo de pacientes com laringite, com a hipótese de que a alteração no trânsito do bolo pela boca e faringe pode estar envolvida com a queixa de disfagia. MÉTODOS: A avaliação videofluoroscópica da deglutição de bolos líquido, pastoso e sólido foi realizada em 21 pacientes com laringite, 10 deles com disfagia e 21 voluntários normais da mesma idade e sexo. Duas deglutições de 5 mL de bolo líquido, duas deglutições de bolo pastoso e duas deglutições de bolo sólido foram avaliadas em sequência casual definida por sorteio. Bolo líquido foi sulfato de bário 100%, e o bolo pastoso foi preparado com 50 mL de bário líquido e 4 g de espessante alimentar (amido e maltodextrina). O bolo sólido foi 2,2 g de uma bolacha macia embebida em bário líquido. A duração da preparação oral, trânsito oral, trânsito faríngeo, depuração da faringe, abertura do esfíncter superior do esôfago, movimento do hióide e do trânsito oral-faríngeo foram medidas. Precedendo a videofluoroscopia todos pacientes realizaram exame de pHmetria de 24 horas. RESULTADOS: O registro do pH intraesofágico distal revelou resultado anormal em 10 pacientes. Pacientes com laringite apresentaram maior duração da preparação oral para bolo pastoso e um tempo de trânsito oral mais rápido para bolo sólido. Os pacientes com laringite e disfagia tiveram uma preparação oral mais longa para bolo pastoso e sólido e tempo de trânsito oral menor com bolos líquido, pastoso e sólido. CONCLUSÃO: Preparação oral mais longa para bolos pastoso e sólido e trânsito mais rápido através da boca são situações associadas com a presença de disfagia em pacientes com laringite.


Subject(s)
Humans , Male , Female , Adult , Aged , Deglutition Disorders/physiopathology , Laryngitis/physiopathology , Deglutition/physiology , Barium , Fluoroscopy/methods , Deglutition Disorders/etiology , Deglutition Disorders/diagnostic imaging , Gastroesophageal Reflux/etiology , Case-Control Studies , Laryngitis/complications , Laryngitis/diagnostic imaging , Food Additives/administration & dosage , Laryngoscopy , Middle Aged
14.
Codas ; 27(4): 392-9, 2015.
Article in English, Portuguese | MEDLINE | ID: mdl-26398264

ABSTRACT

OBJECTIVES: To evaluate the behavior of the phonatory function and the perceived strain in Brazilian young women, before and after a test of prolonged voice use test, for a period of one continuous hour. METHODS: Twenty young women without laryngeal disorders participated in the study and were submitted to vocal acoustic analysis (MDVP-Advanced, CSL-Kay Pentax®), perceptual voice assessment, carried out by five judges, and the measurement of speech-strain level using a visual analog scale before and after a prolonged use of the voice, from the reading of a standardized text for one hour in usual vocal intensity and frequency, without breaks for hydration or vocal rest. The description and comparison between the variables and the appropriate statistical analysis were carried out. RESULTS: The acoustic parameters of fundamental (f0) and low frequency (Flo) of the emission increased after 1 hour of voice use, while the values for the amplitude tremor intensity index (Atri), amplitude variation (vAm), noise-to-harmonic ratio (NHR), and soft phonation index (SPI) were reduced after the prolonged voice use test. The judges agreed with the decrease in the overall level of dysphonia (kappa=0.66), roughness (kappa=0.59), and vocal breathiness (kappa=0.73); increased phonatory stability (kappa=0.64); vocal projection (kappa=0.48); pitch (kappa=0.74); and loudness (kappa=0.65). The phonatory strain increased significantly after the test (p=0.003). CONCLUSION: One hour of prolonged voice use seems to favor laryngeal adaptation and increased adductor muscle activity to maintain vocal efficiency. However, the self-perception of vocal strain is evident and can be understood as a sign of muscle fatigue caused by continuous use.


Subject(s)
Dysphonia/physiopathology , Phonation/physiology , Voice/physiology , Adolescent , Adult , Dysphonia/diagnosis , Female , Humans , Prospective Studies , Severity of Illness Index , Speech Acoustics , Speech Perception , Vocal Cords , Voice Quality , Young Adult
15.
CoDAS ; 27(4): 392-399, July-Aug. 2015. tab
Article in English | LILACS | ID: lil-760413

ABSTRACT

OBJECTIVES: To evaluate the behavior of the phonatory function and the perceived strain in Brazilian young women, before and after a test of prolonged voice use test, for a period of one continuous hour.METHODS: Twenty young women without laryngeal disorders participated in the study and were submitted to vocal acoustic analysis (MDVP-Advanced, CSL-Kay Pentax(r)), perceptual voice assessment, carried out by five judges, and the measurement of speech-strain level using a visual analog scale before and after a prolonged use of the voice, from the reading of a standardized text for one hour in usual vocal intensity and frequency, without breaks for hydration or vocal rest. The description and comparison between the variables and the appropriate statistical analysis were carried out.RESULTS: The acoustic parameters of fundamental (f0) and low frequency (Flo) of the emission increased after 1 hour of voice use, while the values for the amplitude tremor intensity index (Atri), amplitude variation (vAm), noise-to-harmonic ratio (NHR), and soft phonation index (SPI) were reduced after the prolonged voice use test. The judges agreed with the decrease in the overall level of dysphonia (kappa=0.66), roughness (kappa=0.59), and vocal breathiness (kappa=0.73); increased phonatory stability (kappa=0.64); vocal projection (kappa=0.48); pitch (kappa=0.74); and loudness (kappa=0.65). The phonatory strain increased significantly after the test (p=0.003).CONCLUSION: One hour of prolonged voice use seems to favor laryngeal adaptation and increased adductor muscle activity to maintain vocal efficiency. However, the self-perception of vocal strain is evident and can be understood as a sign of muscle fatigue caused by continuous use.


OBJETIVO: Avaliar o comportamento da função fonatória e a sensação de esforço de mulheres jovens, antes e após uma prova de uso prolongado da voz, pelo período de uma hora contínua.MÉTODOS: Participaram 20 mulheres jovens, sem alterações laríngeas, submetidas à analise acústica vocal (MDVP-Advanced, CSL- Kay Pentax(r)), avaliação perceptivo-auditiva da voz, realizada por cinco juízes, e mensuração do nível de esforço fonatório utilizando uma escala visual analógica, antes e após o uso prolongado da voz, a partir da leitura de um texto padronizado por uma hora, em intensidade e frequência vocal habitual, sem pausas para hidratação ou repouso vocal. Foram realizadas a descrição e comparação entre as variáveis e aplicado o tratamento estatístico apropriado.RESULTADOS: Os parâmetros acústicos de frequência fundamental (f0) e de frequência grave da emissão (Flo) aumentaram após uma hora de uso da voz, enquanto as medidas de intensidade do tremor (Atri), da variação da amplitude (vAm), a relação harmônico-ruído (NHR) e a taxa de fonação suave (SPI) diminuíram após a prova de uso prolongado de voz. Os juízes concordaram com a diminuição do grau geral da disfonia (kappa=0,66), da rugosidade (kappa=0,59) e soprosidade vocal (kappa=0,73); o aumento da estabilidade fonatória (kappa=0,64); a projeção vocal (kappa=0,48); o pitch (kappa=0,74) e o loudness (kappa=0,65). O esforço fonatório aumentou significativamente após a prova (p=0,003).CONCLUSÃO: Uma hora de uso prolongado da voz parece favorecer uma adaptação laríngea e aumento da atividade da musculatura adutora para manter a eficiência vocal. Entretanto, a auto percepção do esforço fonatório fica evidente e pode ser compreendido como sinal de fadiga da musculatura ocasionada pelo uso contínuo.


Subject(s)
Adolescent , Adult , Female , Humans , Young Adult , Dysphonia/physiopathology , Phonation/physiology , Voice/physiology , Dysphonia/diagnosis , Prospective Studies , Severity of Illness Index , Speech Acoustics , Speech Perception , Vocal Cords , Voice Quality
16.
Braz Oral Res ; 29(1): S1806-83242015000100301, 2015.
Article in English | MEDLINE | ID: mdl-26892357

ABSTRACT

Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.


Subject(s)
Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnostic imaging , Finger Phalanges/diagnostic imaging , Aged , Aged, 80 and over , Analysis of Variance , Bisphosphonate-Associated Osteonecrosis of the Jaw/pathology , Bisphosphonate-Associated Osteonecrosis of the Jaw/physiopathology , Bone Density , Bone Remodeling/physiology , Case-Control Studies , Cross-Sectional Studies , Female , Finger Phalanges/pathology , Finger Phalanges/physiopathology , Hand/diagnostic imaging , Humans , Jaw/diagnostic imaging , Jaw/pathology , Male , Middle Aged , Multiple Myeloma/pathology , Osteoporosis/chemically induced , Reproducibility of Results , Risk Factors , Time Factors , Ultrasonography
17.
Braz. oral res. (Online) ; 29(1): 1-9, 2015. tab, ilus
Article in English | LILACS | ID: lil-777204

ABSTRACT

Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.


Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Bisphosphonate-Associated Osteonecrosis of the Jaw , Finger Phalanges , Analysis of Variance , Bone Density , Bisphosphonate-Associated Osteonecrosis of the Jaw/pathology , Bisphosphonate-Associated Osteonecrosis of the Jaw/physiopathology , Bone Remodeling/physiology , Case-Control Studies , Cross-Sectional Studies , Finger Phalanges/pathology , Finger Phalanges/physiopathology , Hand , Jaw/pathology , Jaw , Multiple Myeloma/pathology , Osteoporosis/chemically induced , Reproducibility of Results , Risk Factors , Time Factors
18.
Rev. ter. ocup ; 25(3): 255-263, set.-dez. 2014. tab
Article in Portuguese | LILACS | ID: lil-745516

ABSTRACT

INTRODUÇÃO: O câncer de cabeça e pescoço tem elevada incidência e alta mortalidade e seu diagnóstico etratamento influenciam a vida ocupacional da pessoa adoecida e de seus familiares. OBJETIVO: conhecer a configuração dos papéis ocupacionais de pessoas com este tipo de câncer,submetidas a laringectomia total ou parcial. MÉTODO: Estudo quantitativo, exploratório e transversal, aprovado pelo Comitê de Ética (Proc. nº 1102/2010). Foi utilizado o protocolo “Lista de Identificação dos Papéis Ocupacionais”, validada no Brasil; osdados quantitativos foram analisados pelo teste do Qui quadrado. Dados qualitativos complementares foram coletados por entrevista aberta e analisados pelo método de análise de conteúdo temático. CASUÍSTICA: Grupo de estudo com 30 pessoas atendidas pela Cirurgia de Cabeça e Pescoço (CCP), sendo 15 da enfermaria, no pós-cirúrgico imediato, e 15 do Ambulatório, (no mínimo um ano após a cirurgia). Grupo-controle compostopor 30 pessoas sem diagnóstico de câncer. Foram selecionadas 3 do ambulatório (20% do grupo de estudo) para as entrevistas. RESULTADOS: Demonstrou-se que ocorreram mudanças ou perdas de papéis ocupacionais, principalmente do papel de trabalhador. CONCLUSÃO: As consequências psicossociais e ocupacionais do câncer de cabeça e pescoço devem ser consideradas e cuidadas para um melhor e mais eficaz tratamento prestado a essa população.


The head and neck cancer has a high incidence and high mortality and its diagnosis and treatment influence the occupational life of the diseased personand their family. OBJECTIVE: To know the configuration of the occupational roles of people with this type of cancer,undergoing total or partial laryngectomy. METHODS: A quantitative, exploratory cross-sectional study approved by the Ethics Committee (Proc. No. 1102/2010). We used the protocol “List of Identifi cation of Occupational Roles”, validated in Brazil; quantitative data were analyzed by chi-square test. Additionalqualitative data were collected through open interviews and analyzed by the method of content analysis. PATIENTS: Study group with 30 persons served by Head and Neck Surgery (CCP), with 15 ward in the immediate post-surgical, outpatient and 15, (at least one year after surgery). Control group consisting of 30 people without cancer. Were selected from the outpatient clinic3 (20% of the study group) for interviews. RESULTS: It wasdemonstrated that there were changes or loss of occupational roles, especially the role of worker. CONCLUSION: The psychosocial and occupational consequences of head and neck cancer should be considered and cared for better and more effective treatmentprovided to this population.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Head and Neck Neoplasms/surgery , Head and Neck Neoplasms/rehabilitation , Quality of Life/psychology , Interpersonal Relations , Occupational Therapy/psychology , Laryngectomy/psychology , Laryngectomy/rehabilitation , Head and Neck Neoplasms/epidemiology , Sickness Impact Profile
19.
Acta Cir Bras ; 28(5): 391-6, 2013 May.
Article in English | MEDLINE | ID: mdl-23702943

ABSTRACT

PURPOSE: To evaluate and correlate the amplitude of esophageal contractions triggered by swallowing water with dynamic extension and habitual, strong and weak sound intensity in total laryngectomees wearing a tracheoesophageal prosthesis. METHODS: Thirty total laryngectomees using tracheoesophageal voice with a phonatory prosthesis were evaluated by measuring the amplitude of contractions in the proximal, middle and distal esophagus and the pressure of the pharyngoesophageal transition by manometry. In order to measure vocal intensity the subject was asked to emit phonation of the vowel /a/ at habitual, strong and weak intensity which was captured with a sound pressure meter. Dynamic extension was calculated by subtracting strong intensity from weak intensity. RESULTS: A positive correlation was observed between contraction amplitude and dynamic extension in the proximal (rho: 0.45; p=0.01) and distal (rho: 0.41; p=0.02) esophagus There was no correlation with other parameters.. Total laryngectomees wearing a phonatory prosthesis with a dynamic extension above 21 dBNPS had greater contraction amplitude than laryngectomees with a dynamic extension below this value. CONCLUSIONS: There was a positive correlation between pressure amplitude in the proximal and distal esophagus and increased dynamic extension. The individuals with normal dynamic extension had greater contraction amplitude in the proximal esophagus than individuals with dynamic extension lower than the expected values for age.


Subject(s)
Esophagus/physiopathology , Laryngectomy/rehabilitation , Larynx, Artificial , Speech, Esophageal , Carcinoma, Squamous Cell/surgery , Esophagus/surgery , Female , Humans , Laryngeal Neoplasms/surgery , Male , Manometry , Middle Aged , Phonation/physiology , Pressure , Statistics, Nonparametric , Trachea/physiopathology , Trachea/surgery , Voice Quality/physiology
20.
Acta cir. bras ; 28(5): 391-396, May 2013. tab
Article in English | LILACS | ID: lil-674161

ABSTRACT

PURPOSE: To evaluate and correlate the amplitude of esophageal contractions triggered by swallowing water with dynamic extension and habitual, strong and weak sound intensity in total laryngectomees wearing a tracheoesophageal prosthesis. METHODS: Thirty total laryngectomees using tracheoesophageal voice with a phonatory prosthesis were evaluated by measuring the amplitude of contractions in the proximal, middle and distal esophagus and the pressure of the pharyngoesophageal transition by manometry. In order to measure vocal intensity the subject was asked to emit phonation of the vowel /a/ at habitual, strong and weak intensity which was captured with a sound pressure meter. Dynamic extension was calculated by subtracting strong intensity from weak intensity. RESULTS: A positive correlation was observed between contraction amplitude and dynamic extension in the proximal (rho: 0.45; p=0.01) and distal (rho: 0.41; p=0.02) esophagus There was no correlation with other parameters.. Total laryngectomees wearing a phonatory prosthesis with a dynamic extension above 21 dBNPS had greater contraction amplitude than laryngectomees with a dynamic extension below this value. CONCLUSIONS: There was a positive correlation between pressure amplitude in the proximal and distal esophagus and increased dynamic extension. The individuals with normal dynamic extension had greater contraction amplitude in the proximal esophagus than individuals with dynamic extension lower than the expected values for age.


Subject(s)
Female , Humans , Male , Middle Aged , Esophagus/physiopathology , Larynx, Artificial , Laryngectomy/rehabilitation , Speech, Esophageal , Carcinoma, Squamous Cell/surgery , Esophagus/surgery , Laryngeal Neoplasms/surgery , Manometry , Pressure , Phonation/physiology , Statistics, Nonparametric , Trachea/physiopathology , Trachea/surgery , Voice Quality/physiology
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