ABSTRACT
Bleeding Assessment Tools (BATs) have been developed to aid in the standardized evaluation of bleeding symptoms. The Vicenza Bleeding Questionnaire (BQ), published in 2005, established a common framework and scoring key that has undergone subsequent modification over the years, culminating in the publication of the ISTH-BAT in 2010. Understanding the normal range of bleeding scores is critical when assessing the utility of a BAT. Within the context of The Merging Project, a bioinformatics system was created to facilitate the merging of legacy data derived from four different (but all Vicenza-based) BATs; the MCMDM1-VWD BQ, the Condensed MCMDM-1VWD BQ, the Pediatric Bleeding Questionnaire and the ISTH-BAT. Data from 1040 normal adults and 328 children were included in the final analysis, which showed that the normal range is 0-3 for adult males, 0-5 for adult females and 0-2 in children for both males and females. Therefore, the cut-off for a positive or abnormal BS is ≥4 in adult males, ≥6 in adult females and ≥3 in children. This information can now be used to objectively assess bleeding symptoms as normal or abnormal in future studies.
Subject(s)
Hemorrhage/blood , Hemorrhage/diagnosis , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Child , Child, Preschool , Computational Biology/methods , Female , Hemophilia A/blood , Hemophilia A/diagnosis , Hemorrhage/etiology , Humans , Infant , Male , Middle Aged , Reference Values , Severity of Illness Index , Surveys and Questionnaires , Young Adult , von Willebrand Diseases/blood , von Willebrand Diseases/diagnosisSubject(s)
Hemorrhage/etiology , Surveys and Questionnaires , von Willebrand Diseases/diagnosis , Adolescent , Child , Child, Preschool , Female , Humans , Infant , MaleABSTRACT
As children infected with HIV live longer, pediatric nurses who care for these patients need to be familiar with adolescent development and to anticipate physiologic and behavioral changes that will occur in this population. Concerns regarding confidentiality, autonomy, medication needs and compliance may become paramount. Learning how to interview adolescents and becoming comfortable with adolescent sexuality issues will enhance the patient-provider relationship.
Subject(s)
Adolescent/physiology , HIV Infections/nursing , Pediatric Nursing/methods , Psychology, Adolescent , Survivors , Female , HIV Infections/physiopathology , HIV Infections/psychology , Humans , MaleABSTRACT
Intelligibility data, phonetic contrast errors, and information regarding subsystem involvement were examined in 29 highly intelligible subjects (18 women and 11 men) with amyotrophic lateral sclerosis. Results are discussed in terms of data for individual subjects, the group as a whole, and for subgroups based on dysarthric status and gender. Of particular interest are findings that suggest early laryngeal involvement as well as gender-related differences for several contrasts.
Subject(s)
Amyotrophic Lateral Sclerosis/complications , Dysarthria/etiology , Phonetics , Speech Intelligibility , Adult , Aged , Female , Humans , Male , Middle Aged , Random Allocation , Severity of Illness Index , Sex Factors , Speech Production MeasurementABSTRACT
The purpose of this study was to analyze the changes in specific speech parameters in 14 patients, 7 dysarthric and 7 non-dysarthric, with amyotrophic lateral sclerosis (ALS), over a 6-month period. Measurements of single word intelligibility, F2 formant trajectories (extent, duration and rate) and diadochokinetic rate showed decreased performance in dysarthric patients as compared to non-dysarthric patients at baseline. F2 transition rates of less than 4 Hz/msec were seen only in dysarthric ALS patients. A relationship between the F2 transition rate and single word intelligibility was noted for patients with moderate to high intelligibility, but at lower levels of intelligibility the F2 rate reached a plateau despite continued decline in intelligibility. Our results support the need for frequent evaluation of dysarthric ALS patients to better understand the relationship between intelligibility and the acoustic parameters of speech.
