Kidney transplantation improves baroreceptor sensitivity.

Kidney transplant recipients as well as patients on hemodialysis frequently share an increased risk of cardiovascular diseases. Besides other factors, modulations in central neural blood pressure regulation have to be considered as a pathogenetic factor. In this study, baroreceptor function as a possible modulator of blood pressure and the activity of the generating components of the sympathetic nervous system were estimated in 20 kidney transplant recipients, 20 normotensive patients on hemodialysis and 20 age-matched volunteers using the sequence analysis technique and Fast Fourier Transformation (FFT). No blood pressure differences could be measured (83.7+/-2.5 vs. 82.5+/-3.8 vs. 79.2+/-2.4 mm Hg). Pulse interval-blood pressure sequences and the slope of delta pulse interval/delta mean arterial blood pressure of these sequences, representing baroreceptor sensitivity, did not differ between kidney transplant recipients and controls (11.2+/-1.4 vs. 13.4+/-1.3 ms/mm Hg), whereas in hemodialysis patients a reduced baroreceptor sensitivity (5.2+/-1.2 ms/mm Hg) was detected. The 66-129 mHz component (Mayer waves) of heart rate and blood pressure spectrum in normals (650+/-57 and 630+/-70 modulus) significantly (p<0.05) exceeded its equivalent in kidney transplant recipients (430+/-32 and 452+/-27 modulus) and patients on hemodialysis (375+/-38 and 394+/-40 modulus). In conclusion, our study provided evidence that both in kidney transplant and dialysis patients a decreased activity of the generating compounds of the sympathetic nervous system can be detected as compared to healthy volunteers. In contrast to hemodialysis patients, the baroreceptor sensitivity is unaffected in kidney transplant recipients and may, therefore, not contribute to the development of cardiovascular diseases.

Acute and persistant effects of smoking on the baroreceptor function.

Recent studies showed that to smoke four cigarettes within one hour impairs baroreflex sensitivity in humans. In the present study, these effects were qualified more precisely from blood pressure and heart rate records by a sequence analysis and by Fourier analysis of Finapres-registrations. The Mayer waves of the heart rate PDS (power density spectrum), partially representing sympathetic activity, increased during smoking (83.7 +/- 1.0 AU to 89.5 +/- 1.1 AU, P < or = 0.05) and decreased after smoking (86 +/- 1.0 AU, P < or = 0.05). They did, however, not reach baseline levels again within 30 min. Probably due to this, mean arterial blood pressure (64.3 +/- 1.3 mmHg vs. 76.9 +/- 1.3 mmHg, P < 0.05) and heart rate (71.8 +/- 1.4 min(-1) vs. 82.9 +/- 1.4 min(-1), P < 0.05) increased unequivocally after smoking. On the other hand, baroreflex sensitivity decreased dramatically from 15.4 +/- 1 to 11.2 +/- 0.6 ms mmHg(-1) (P < 0.05). This finding was associated with an increased heart rate variability after smoking (6 +/- 0.5 min(-1) vs. 9.2 +/- 1 min(-1)) Thus, the present study provides evidence that chronic tobacco (nicotine)-abuse causes pathologic alterations of the baroreflex control. In synergism with other processes like elevated catecholamine blood levels, these alterations may contribute to the higher risk of cardiovascular diseases.

Blood pressure control in kidney transplant recipients: influence of immunosuppression.

1. Disturbances of the blood pressure regulation, probably due to dysfunction of the autonomic nervous system, are well known complications in chronic renal failure. Haemodialysis and transplantation have been reported to ameliorate nerve dysfunction. 2. In this study, the function of the blood pressure control was investigated in kidney transplant recipients after longtime haemodialysis treated with ciclosporine A and tacrolimus and compared to healthy individuals. To investigate the influence of immunosuppression, the measurements were performed twice, at low and high whole blood concentrations of ciclosporine and tacrolimus. Besides ciclosporine, tacrolimus, azathioprine and prednisolone no other drugs were used in the group of kidney transplant recipients. 3. Kidney transplant recipients (KTR) treated with ciclosporine showed reduced blood pressure and heart rate responses to the cardiovascular stress tests (head-up tilt and cold pressure test) under basal conditions. Two hours after ciclosporine application, the differences in the responses to cardiovascular stress tests between KTR and controls were significantly more pronounced. 4. Patients with tacrolimus immunosuppression showed a similar blood pressure and heart rate response under basal conditions. Two hours after drug application, the blood pressure response following orthostatism and heart rate response to the cold pressure test were significantly higher in tacrolimus treated patients. 5. Our results indicate, that kidney transplant recipients still express an altered function of the blood pressure control. Furthermore, ciclosporine A and tacrolimus seem to contribute to dysfunction of the blood pressure regulation by their own. Tacrolimus immunosuppression does not seem to offer advantages concerning the function of the blood pressure control as compared to ciclosporine A.

Cyclosporine A modulates baroreceptor function in kidney transplant recipients.

Cyclosporine has been described to increase the sympathetic tone. Alterations in sympathetic tone may contribute to baroreceptor dysfunction. Therefore, in this study baroreceptor function in 20 kidney transplant recipients was investigated under both low and high cyclosporine whole blood concentrations using the sequence analysis technique. The sympathetic nerve activity was estimated by calculating the low frequency oscillation of heart rate and blood pressure following Fast Fourier Transformation (FFT). Besides cyclosporine, azathioprine and prednisolone no other drugs were used. The increase in cyclosporine whole blood levels (from 101+/-13.4 ng/ml to 469+/-52 ng/ml) did not change mean arterial blood pressure significantly (83.7+/-2.5 vs. 82.2+/-2.0 mm Hg). Baroreflex sensitivity in +PI/+RR (+pulsinterval/+blood pressure) sequences, however, increased from 11.2+/-0.4 to 13.0+/-0.5 ms/mm Hg, whereas it was reduced in -PI/-RR (-pulsinterval/-blood pressure) sequences (14.4+/-0.3 to 12.5+/-1.1 ms/mm Hg). The increase in cyclosporine whole blood concentrations was associated with an increase in low frequency oscillation of heart rate (430+/-12 to 461+/-13) and blood pressure (452+/-9 to 469+/-12), indicating an enhanced sympathetic tone. Our results provide evidence that cyclosporine A by itself alters baroreceptor function. An imbalance between the sympathetic and parasympathetic nervous system due to an enhanced sympathetic tone may explain the reduction in -PI/-RR and the increase in +PI/+RR sequence baroreflex sensitivity.

Coincidence of cytomegalovirus retinitis and central retinal vein occlusion in a patient with hemophilia B and AIDS.

A 37-year-old man with hemophilia B, acquired immunodeficiency syndrome, and a unilateral cytomegalovirus retinitis developed a central retinal vein occlusion. This vascular complication occurred despite effective antiviral drug treatment with improvement of the fundus and despite decreased blood coagulability due to hemophilia B. Additional analyses of thrombophilic parameters did not reveal hints of systemic thrombophilia, suggesting that toxic and inflammatory effects of cytomegalovirus itself were responsible for the ophthalmologic aggravation.

Progressive peripheral and central sensory tract lesion in HIV-infected patients evidenced by evoked potentials (a three-year follow-up study).

OBJECTIVE: To investigate progression of peripheral and central sensory tract lesion and its correlation to immunological deterioration. METHODS: Clinical and neurophysiological investigation (evoked potentials of the median and tibial nerve) and immunological parameters (CD4-cells, beta 2-microglobuline) were followed up in 160 patients (24 females, 136 males, HIV infection for 2.7 +/- 2.3 years, mv +/- 1 sd) up to four times over approximately 3 years regardless of disease stage and evidence of neurological symptoms. Recordings were done using needle electrodes over the Th12 and C7 spinous process and from the scalp (10/20 system) in the conventional manner. Statistical analysis was performed intraindividually and in comparison to normal laboratory values (n = 96). RESULTS: All parameters deteriorated during the follow-up period. Statistical analysis showed significant differences between probands and patients for evoked potentials, but also a significant deterioration for evoked potentials after three years at the end of the follow-up study. A significant correlation between progressive impairment of evoked potentials and laboratory data was found. CONCLUSION: HIV infection induces a progressive lesion of the ascending sensory tracts. The results indicate a peripheral neuropathy as well as a progressive lesion of the ascending central sensory tracts. Pathogenesis of polyneuropathy and of central sensory tract lesion is up to now conjectural. Laboratory investigations indicate a clear-cut correlation between immunological alterations induced by HIV infection and its neurologic manifestation on ascending sensory tracts.

High-signal lesions in the midbrain on T1-weighted MRI in an HIV-infected patient.

In addition to opportunistic infections, neoplasms or cerebrovascular complications, metabolic encephalopathies are a classical cause of diffuse brain dysfunction in HIV infection and are frequent in the terminal stage. We report an HIV-infected patient with symmetrical, focally increased signal in the midbrain on proton density-and T1-weighted MRI without corresponding high signal on T2-weighted images or on CT. While the precise nature and cause of this uncommon finding is not fully understood, the available evidence suggests that these lesions might represent a novel metabolic encephalopathy.