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1.
Proc Soc Exp Biol Med ; 150(3): 681-5, 1975 Dec.
Article in English | MEDLINE | ID: mdl-174141

ABSTRACT

An interaction between sarcoma-180/TG cells and vesicular stomatitis virus in adult mice resulted in the rapid onset of extensive mortality. This interaction, termed lethal synergy, occurred only at early stages of ascites induction in animals with no prior virus contact. A significant sparing effect conferred by the serotonin antagonist dibenamine was reversed by the administration of serotonin. The cause of death was not determined, but a mechanism involving hypersensitivity is indicated.


Subject(s)
Sarcoma 180/mortality , Vesicular stomatitis Indiana virus/growth & development , Animals , Dibenzylchlorethamine/pharmacology , Female , Hypersensitivity , Mice , Neoplasm Transplantation , Sarcoma 180/immunology , Serotonin/pharmacology , Serotonin Antagonists , Vesicular stomatitis Indiana virus/immunology
2.
Antimicrob Agents Chemother ; 6(4): 524-5, 1974 Oct.
Article in English | MEDLINE | ID: mdl-4157357

ABSTRACT

Extracts from two species of marine red algae, Cryptosyphonia woodii and Farlowia mollis, specifically inhibited herpes simplex virus replication in vitro.


Subject(s)
Eukaryota , Herpesviridae/physiology , Virus Replication/drug effects , Plant Extracts/pharmacology
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