The Risk, Need, and Responsivity Relevance of Working Alliance in a Sexual Offense Treatment Program: Its Intersection With Psychopathy, Diversity, and Treatment Change.

The current study examined the self-reported working alliance of men attending a high intensity sexual offense treatment program and its associations with psychopathy, sexual violence risk, treatment change, and recidivism, in a Canadian sample of 317 incarcerated men followed up an average of approximately 10 years post release. Working Alliance Inventory (WAI; Horvath & Greenberg, 1989) self-reported total, Task, Bond, and Goal scores were positively correlated with treatment related changes in risk, and inversely associated with Psychopathy Checklist-Revised (PCL-R; Hare, 1991; Wang & Hare, 2003) scores. The Affective facet of the PCL-R, representing the callous-unemotional features of the syndrome, uniquely predicted lower Bond and Goal scores controlling for the other facets. Cox regression survival analyses demonstrated that sexual violence risk predicted increased sexual recidivism while change predicted decreased sexual recidivism controlling for PCL-R total score; however, WAI scores (particularly the Goal component) were also unexpectedly associated with increased sexual recidivism. For violent recidivism, psychopathy, risk, and change incremented the prediction of general violence, while the WAI was not significantly associated with this outcome. A set of parallel analyses, stratified by Indigenous ethnocultural heritage, demonstrated some continuity, but also potential areas of difference, in substantive findings. Risk, need, responsivity implications of the working alliance for the treatment of high psychopathy correctional clientele, and how this may intersect with Indigenous heritage, are discussed.

Characterisation of TbSmee1 suggests endocytosis allows surface-bound cargo to enter the trypanosome flagellar pocket.

All endocytosis and exocytosis in the African trypanosome Trypanosoma brucei occurs at a single subdomain of the plasma membrane. This subdomain, the flagellar pocket, is a small vase-shaped invagination containing the root of the single flagellum of the cell. Several cytoskeleton-associated multiprotein complexes are coiled around the neck of the flagellar pocket on its cytoplasmic face. One of these, the hook complex, was proposed to affect macromolecule entry into the flagellar pocket lumen. In previous work, knockdown of T. brucei (Tb)MORN1, a hook complex component, resulted in larger cargo being unable to enter the flagellar pocket. In this study, the hook complex component TbSmee1 was characterised in bloodstream form T. brucei and found to be essential for cell viability. TbSmee1 knockdown resulted in flagellar pocket enlargement and impaired access to the flagellar pocket membrane by surface-bound cargo, similar to depletion of TbMORN1. Unexpectedly, inhibition of endocytosis by knockdown of clathrin phenocopied TbSmee1 knockdown, suggesting that endocytic activity itself is a prerequisite for the entry of surface-bound cargo into the flagellar pocket.

High-psychopathy men with a history of sexual offending have protective factors too: But are these risk relevant and can they change in treatment?

OBJECTIVE: Psychopathy is a serious personality disorder reputed for resistance to correctional and forensic mental health treatment and synonymous with being high risk for different recidivism outcomes; it is not readily associated with an abundance of positive qualities or protective factors. Research has yet to examine the presence of protective factors as a function of psychopathy in correctional samples and the risk-relevance of protective factors for high-psychopathy men. METHOD: The present study examined the association of psychopathy and protective factors to recidivism in a Canadian sample of 461 men who attended sexual-offense-specific treatment and followed up nearly 10-year postrelease. The Psychopathy Checklist-Revised (PCL-R; Hare, The Hare psychopathy-checklist-revised, 1991; Hare, Manual for the revised psychopathy checklist, 2003) and the Structured Assessment of Protective Factors (SAPROF; de Vogel et al., The International Journal of Forensic Mental Health, 2011, 10, 171) were rated from institutional files and recidivism data were obtained from official criminal records. RESULTS: PCL-R scores were inversely related to SAPROF scores; however, even men scoring high on the PCL-R made significant pre-post changes on protective factors. PCL-R and SAPROF scores predicted sexual, violent, and general recidivism; treatment-related changes in protective factors, controlling for PCL-R score, were significantly associated with decreased violent recidivism. CONCLUSIONS: Protective factors can and do change with purposive change agents (e.g., correctional treatment), even among individuals with substantial psychopathic traits. The role and risk relevance of protective factors in sexual violence risk assessment and management with high psychopathy clientele are discussed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).