ABSTRACT
INTRODUCTION: Heterozygous familial hypercholesterolaemia (heFH) is the most common monogenic cause of premature atherosclerotic cardiovascular disease. The precise diagnosis of heFH is established by genetic testing. This systematic review will investigate the risk factors that predict cardiovascular events in patients with a genetic diagnosis of heFH. METHODS AND ANALYSIS: Our literature search will cover publications from database inception until June 2023. We will undertake a search of CINAHL (trial), clinicalKey, Cochrane Library, DynaMed, Embase, Espacenet, Experiments (trial), Fisterra, ÍnDICEs CSIC, LILACS, LISTA, Medline, Micromedex, NEJM Resident 360, OpenDissertations, PEDro, Trip Database, PubPsych, Scopus, TESEO, UpToDate, Web of Science and the grey literature for eligible studies. We will screen the title, abstract and full-text papers for potential inclusion and assess the risk of bias. We will employ the Cochrane tool for randomised controlled trials and non-randomised clinical studies and the Newcastle-Ottawa Scale for assessing the risk of bias in observational studies. We will include full-text peer-reviewed publications, reports of a cohort/registry, case-control and cross-sectional studies, case report/series and surveys related to adults (≥18 years of age) with a genetic diagnostic heFH. The language of the searched studies will be restricted to English or Spanish. The Grading of Recommendations, Assessment, Development and Evaluation approach will be used to assess the quality of the evidence. Based on the data available, the authors will determine whether the data can be pooled in meta-analyses. ETHICS AND DISSEMINATION: All data will be extracted from published literature. Hence, ethical approval and patient informed consent are not required. The findings of the systematic review will be submitted for publication in a peer-reviewed journal and presentation at international conferences. PROSPERO REGISTRATION NUMBER: CRD42022304273.
Subject(s)
Cardiovascular Diseases , Hyperlipoproteinemia Type II , Humans , Cross-Sectional Studies , Risk Factors , Cardiovascular Diseases/genetics , Hyperlipoproteinemia Type II/complications , Hyperlipoproteinemia Type II/genetics , Systematic Reviews as TopicABSTRACT
BACKGROUND: There is a growing interest in designing instruments to assess obsessive-compulsive symptoms in children. The Obsessive-Compulsive Inventory-Child Version (OCI-CV) has showed to be a valid in the evaluation of OCD in clinical and nonclinical populations. The main goal in this study was to analyze factor structure and psychometric properties of the OCI-CV in a community Spanish sample. METHOD: Data were collected from 914 children/adolescents with a mean age of 13.01 (SD = 1.96; Males = 51.3%). Exploratory factor analysis was carried out in order to study the internal structure of the OCI-CV Spanish version. Further, internal consistency, test-retest reliability, and convergent and discriminant validity of the total score and the factors obtained were examined. Finally, age and gender differences were also explored. RESULTS: Exploratory factor analysis yielded a similar structure to the original OCI-CV with the following six factors: Washing/Checking, Obsession, Ordering, Doubting, Neutralizing, and Hoarding. The internal consistency was strong for the total score, but moderate for the subscales. The Spanish version of the OCI-CV showed evidences of test-retest reliability and convergent and discriminant validity. CONCLUSION: The Spanish version of the OCI-CV is an instrument with adequate psychometric properties to assess obsessions and compulsions in Spanish children/adolescents
ANTECEDENTES: existe un creciente interés en el diseño de instrumentos que evalúen los síntomas obsesivo-compulsivos en niños. El Inventario Obsesivo Compulsivo-Versión para Niños (OCI-CV) ha demostrado ser válido para evaluar estos síntomas en población clínica y no clínica. El objetivo de este estudio fue analizar la estructura factorial y las propiedades psicométricas del OCI-CV en población española comunitaria. MÉTODO: se recogieron datos de 914 niños/adolescentes con una edad media de 13,01 años (DT = 1.96; 51.3% varones). Se realizó un análisis factorial exploratorio. Posteriormente se examinó la consistencia interna, la fiabilidad test-retest y la validez convergente y divergente de la puntuación total del instrumento y de los factores obtenidos. Finalmente, se comprobó la existencia de diferencias en función del sexo y la edad de los participantes. RESULTADOS: los resultados mostraron una estructura similar a la del OCI-CV original, compuesta por los siguientes factores: Lavado/Comprobación, Obsesión, Orden, Duda, Neutralización y Acumulación. La consistencia interna fue buena para la puntuación total, aunque moderada para las diferentes subescalas. La versión en castellano del OCI-CV mostró evidencias de fiabilidad test-retest y validez convergente y discriminante. CONCLUSIONES: OCI-CV es una herramienta con adecuadas propiedades psicométricas para la valoración de obsesiones y compulsiones en niños/adolescentes españoles
Subject(s)
Humans , Male , Female , Middle Aged , Alcoholism/diagnosis , Tobacco Use Disorder/diagnosis , Substance-Related Disorders/diagnosis , Substance Abuse Detection/legislation & jurisprudence , Substance Abuse Detection/methods , Substance Abuse Detection/statistics & numerical data , Psychometrics/methods , Psychometrics/statistics & numerical data , Substance Abuse Detection/psychology , Substance Abuse Detection/standards , Substance Abuse Detection/trends , Surveys and Questionnaires/standards , Surveys and QuestionnairesABSTRACT
BACKGROUND: To evaluate the psychometric properties of the Spanish version of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) and its effectiveness as a screening tool for problematic alcohol, tobacco and other psychoactive substance use in groups of low, moderate, and high risk users. METHODS: A test battery including the ASSIST and several standardized screening, assessment, and diagnostic instruments was administered to 485 patients recruited in different primary health-care facilities and specialized addiction treatment units from Health Area 11 in Madrid. RESULTS: ASSIST cut-off scores show a good sensitivity and specificity for discrimination between substance use and abuse and between abuse and dependence. Concurrent validity was demonstrated by significant correlations between ASSIST scores and scores from the Mini-International Neuropsychiatric Interview (MINI-Plus), the Alcohol Use Disorders Identification Test (AUDIT), the Revised Fagerstrom Tolerance Questionnaire (RTQ) and the Severity of Dependence Scale (SDS). CONCLUSIONS: Psychometric properties of the Spanish version of the ASSIST indicate that is a valid screening test for identifying substance use disorders in various health-care settings.
