1.
Bioorg Med Chem Lett
; 11(21): 2837-41, 2001 Nov 05.
Article
in English
| MEDLINE
| ID: mdl-11597411
ABSTRACT
The first reported synthesis of the DNA-PK inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035) is described. The structure of OK-1035 was validated by X-ray crystallography. An IC(50) value of 100 microM was determined for inhibition of DNA-PK, and this is approximately 12-fold higher than that reported previously.