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1.
Chemosphere ; 167: 255-261, 2017 Jan.
Article in English | MEDLINE | ID: mdl-27728884

ABSTRACT

OTNE [1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one; trade name Iso E Super] is a fragrance ingredient commonly used in consumer products which are disposed down the drain. This research measured effluent and sludge concentrations of OTNE at 44 US wastewater treatment plants (WWTP). The mean effluent and sludge concentrations were 0.69 ± 0.65 µg/L and 20.6 ± 33.8 mg/kg dw respectively. Distribution of OTNE effluent concentrations and dilution factors were used to predict surface water and sediment concentrations and distributions of OTNE sludge concentrations and loading rates were used to predict terrestrial concentrations. The 90th percentile concentration of OTNE in US WWTP mixing zones was predicted to be 0.04 and 0.85 µg/L under mean and 7Q10 low flow (lowest river flow occurring over a 7 day period every 10 years) conditions respectively. The 90th percentile sediment concentrations under mean and 7Q10 low flow conditions were predicted to be 0.081 and 1.6 mg/kg dw respectively. Based on current US sludge application practices, the 90th percentile OTNE terrestrial concentration was 1.38 mg/kg dw. The probability of OTNE concentrations being below the predicted no effect concentration (PNEC) for the aquatic and sediment compartments was greater than 99%. For the terrestrial compartment, the probability of OTNE concentrations being lower than the PNEC was 97% for current US sludge application practices. Based on the results of this study, OTNE concentrations in US WWTP effluent and sludge do not pose an ecological risk to aquatic, sediment and terrestrial organisms.


Subject(s)
Ecology , Environmental Monitoring , Perfume/analysis , Polycyclic Aromatic Hydrocarbons/analysis , Wastewater/chemistry , Water Pollutants, Chemical/analysis , Ecosystem , Probability , Risk Assessment , Rivers , Sewage/chemistry , United States
2.
Toxicol Lett ; 198(2): 255-62, 2010 Oct 05.
Article in English | MEDLINE | ID: mdl-20633615

ABSTRACT

REACH requires all available (eco)toxicological information, whether protocol studies, other experiments, or non-testing approaches such as read-across or (Q)SAR, to be collected and evaluated. However, guidance documents only limitedly address how adequacy of (eco)toxicological information can be assessed consistently and transparently. We propose an Integrated Assessment Scheme (IAS) for the evaluation of (eco)toxicological data. The IAS consists of three modules: (i) the reliability of the data; (ii) the validity of the methods the data are generated from and; (iii) the regulatory need of the data. Each module is assessed and documented using adjusted OECD principles for the validation of (Q)SARs. These adjusted principles provide a harmonised set of criteria for the evaluation of all types of (eco)toxicological data. Assessment codes, similar to Klimisch codes, are assigned to the evaluated information in each module. The coherent combination of the assessment codes of all three modules determines the overall adequacy of information for fulfilling the information requirement in REACH, and can serve as a weight in a Weight of Evidence procedure as mentioned in REACH Annex XI.


Subject(s)
Databases, Factual , Ecotoxicology , Hazardous Substances , Animals , Ecotoxicology/legislation & jurisprudence , Ecotoxicology/methods , Ecotoxicology/standards , Endpoint Determination , European Union , Government Regulation , Guidelines as Topic , Hazardous Substances/classification , Hazardous Substances/toxicity , Quantitative Structure-Activity Relationship , Reproducibility of Results , Risk Assessment/legislation & jurisprudence , Risk Assessment/methods , Risk Assessment/standards
3.
Arch Environ Contam Toxicol ; 52(1): 22-31, 2007 Jan.
Article in English | MEDLINE | ID: mdl-17061051

ABSTRACT

At present there is a high level of uncertainty about whether or not soil samples, which are required to be toxicologically characterized, could be preserved without affecting their toxicological characteristics. In the existing DIN/ISO standards for soil investigations, there is no documentation on the storage of soil samples after collection for (eco-)toxicological investigations. Furthermore, procedures for receiving justifiable and verifiable results from soil samples are quite vague. Therefore, the stability and changes in the biological effects of different soil contaminants were investigated by varying the storage conditions and the storage times of the soil. The limitations of storing soils could therefore be subsequently outlined. Recommendations for the optimization of storage conditions for back-up soil samples were made. These recommendations have the capability of finding entrance into DIN/ISO standards.


Subject(s)
Environmental Monitoring/methods , Humic Substances/analysis , Soil Pollutants/analysis , Specimen Handling/methods , Xenobiotics/analysis , Hydrogen-Ion Concentration , Solubility , Temperature , Time Factors , Water
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