Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
Add more filters










Database
Language
Publication year range
1.
J Med Liban ; 60(3): 125-35, 2012.
Article in English | MEDLINE | ID: mdl-23198452

ABSTRACT

BACKGROUND: Antimicrobial resistance has been inflecting deleterious health and economic consequences locally and globally. This study addresses the patterns and trends of bacterial resistance to antimicrobial agents over a decade, at a major tertiary care center in Beirut. METHODS: Data on bacterial susceptibility patterns at the CAP accredited Clinical Microbiology Laboratory is analyzed from January 2000 to November 2011, along with related different studies conducted during this period. RESULTS: Increasing rates of ESBL-producing isolates were noted for Escherichia coli, Klebsiella pneumoniae, Salmonella spp. and Shigella spp. Resistance to carbapenems remains problematic in Acinetobacter spp, and Pseudomonas aeruginosa, and started emerging in E. coli and K. pneumoniae. Tigecycline and colistin maintained excellent activity against most ESBL and carbapenem resistant bacteria relevant to the treatment by these agents. Resistance to quinolones is being encountered in Streptococcus pneumoniae, Haemophilus influenzae, Salmonella spp. and Shigella spp. Methicillin resistant Staphylococcus aureus (MRSA), though remaining relatively high, showed decreasing trends of resistance, while vancomycin maintain uniform activity. Rare and sporadic vancomycin resistant strains in enterococci are encountered. Macrolide and clindamycin increasing rates of resistance is noted in S. pneumoniae, group A streptococci, S. aureus, viridans streptococci and some others. CONCLUSION: Physicians should be aware of the local epidemiology of antimicrobial resistance to properly guide the initial therapy. These resistance problems can be attributed to uncontrolled use of antimicrobial agents, thus, highlighting the need for antimicrobial stewardship to curb this threat.


Subject(s)
Escherichia coli/drug effects , Klebsiella/drug effects , Staphylococcus/drug effects , Streptococcus/drug effects , Drug Resistance, Bacterial , Humans , Lebanon , Tertiary Care Centers , Time Factors
2.
Acad Psychiatry ; 36(2): 126-8, 2012 Mar 01.
Article in English | MEDLINE | ID: mdl-22532203

ABSTRACT

OBJECTIVE: The authors sought to determine psychiatry residents' perceptions on the current method of evaluating professional role competency and the use of multi-source feedback (MSF) as an assessment tool. METHOD: Authors disseminated a structured, anonymous survey to 128 University of Toronto psychiatry residents, evaluating the current mode of assessment of the professional role and the use of MSF. RESULTS: The overall response rate was 86%. Fewer than half (44%) of residents felt that their professional role is adequately evaluated, and 84% were in favor of incorporating MSF for the evaluation of this competency. Respondents believed their primary supervisor should have the largest proportional impact on the evaluation (50%), followed by allied heath staff (19%), patients (16%), co-residents (12%), self (11%), and administrative staff (9%). CONCLUSION: On the basis of this needs assessment and the Royal College recommendations, MSF may be considered a potential assessment tool for evaluating psychiatry residents in their professional role.


Subject(s)
Feedback , Internship and Residency/methods , Professional Competence , Professional Role , Psychiatry/education , Educational Measurement , Humans , Surveys and Questionnaires
3.
Water Sci Technol ; 55(12): 133-8, 2007.
Article in English | MEDLINE | ID: mdl-17674839

ABSTRACT

Experimental studies of photocatalytic oxidation (PCO) of VX-gas simulation substance cysteamine-S-phosphate sodium salt (NaHPO3S-CH2-CH2-NH2, CPSS) at various initial concentrations and pH were undertaken. PCO ultimately resulted in complete mineralisation of CPSS. The PCO byproducts of CPSS include acetate, oxalate and trace amounts of formate ions. The formation rates of acetate and phosphate were equal to the rate of degradation of CPSS, which indicates easy breakage of P-S, C-S and C-N bonds. Sulphate was formed more slowly due to stepwise oxidation of reduced sulphur. Amino group, generally transformed to ammonia, was partially oxidised to nitrite and nitrate in alkaline media. The fastest mineralisation in terms of both TOC degradation and phosphate formation was observed in neutral media. Under neutral media conditions, the PCO rate increased linearly with the CPSS concentration increase. The maximum efficiency by TOC degradation was observed as large as 77 mg per Wh of incident UV flux with quantum efficiency 3.8%.


Subject(s)
Gases/chemistry , Organothiophosphorus Compounds/chemistry , Catalysis , Molecular Structure , Oxidation-Reduction , Photochemistry
4.
Dev Neuropsychol ; 26(3): 753-74, 2004.
Article in English | MEDLINE | ID: mdl-15525568

ABSTRACT

Four studies examined (a) how event-related potentials (ERPs) change as the number of trials averaged increases and (b) the statistical implications of comparing ERPs composed of different numbers of trials. Experiment 1 utilized data from 7-year-old children performing an oddball task. The other three experiments used simulated data with different distributions of P3 peak latency. In all 4 experiments, peak amplitude decreased and the mean amplitude of the 300 to 900 msec interval remained stable as the number of trials averaged increased. The standard deviations of both measures decreased. These data show that the decrease in peak amplitude with increasing numbers of trials that has been found in other studies is not solely due to the elimination of residual noise but is likely to also involve a fundamental aspect of signal averaging and the algorithm used to select peaks. Furthermore, these experiments expose the possibility of statistical errors when investigators compare average ERPs composed of small versus large numbers of trials as is often done when the oddball paradigm is used.


Subject(s)
Attention/physiology , Discrimination Learning/physiology , Evoked Potentials, Auditory/physiology , Acoustic Stimulation/methods , Child , Computer Simulation , Electroencephalography/methods , Female , Humans , Male , Reaction Time , Time Factors
5.
Met Based Drugs ; 8(4): 199-210, 2001.
Article in English | MEDLINE | ID: mdl-18475997

ABSTRACT

A number of organosilicon and organogermanium derivatives and some related compounds including the N-substituted. 2-[1-naphthylmethyl]-2-imidazoline and 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been prepared and the toxicity of some compounds have been determined in mice. In this paper we report the synthesis and the evaluation of the pharmacological activity of new organosilicon and organogermanium, compounds such as sila- and germadithioacetals derived from N-substituted naphthylimidazolne.

6.
Inorg Chem ; 39(24): 5492-5, 2000 Nov 27.
Article in English | MEDLINE | ID: mdl-11154565

ABSTRACT

Syntheses of the (divalent group 14 species)dicarbonyl(cyclopentadienyl)manganese (Salen)M=Mn(CO)2(eta 5-C5H5) [M = Ge (1), Sn (2), Pb (3)] and [(Salen)tin(II)]tetracarbonyliron (Salen)Sn=Fe(CO)4 (4) are reported. The structures of 2 and 4 were determined by X-ray crystallography. The observed Sn-Mn bond length, 2.4428(7) A, is the shortest distance observed for this type of bond and corresponds to considerable multiple bonding between these atoms. In complex 4, the iron atom has a slightly distorted trigonal-bipyramidal coordination sphere; the (Salen)tin(II) ligand occupies an axial site, indicating that it functions in this complex as a strong sigma-donor and weak pi-acceptor ligand. Crystal data for 2: orthorhombic, P2(1)2(1)2(1), a = 6.972(1) A, b = 15.678(2) A, c = 19.032(2) A, alpha = beta = gamma = 90 degrees, V = 2080.3(5) A3, T = 173(2) K, Z = 4. Crystal data for 4: triclinic, P1, a = 8.465(2) A, b = 9.795(3) A, c = 13.213(4) A, alpha = 105.55(3) degrees, beta = 105.15(3) degrees, gamma = 100.84(3) degrees, V = 978.7(5) A3, T = 173(2) K, Z = 2.

7.
Met Based Drugs ; 6(1): 49-60, 1999.
Article in English | MEDLINE | ID: mdl-18475880

ABSTRACT

The present review describes the work carried out during the last 20 years in the field of the radioprotective activity and toxicity of several classes of organosilicon and organogermanium compounds (i.e. metallathiazolidines, metalladithioacetals, metallatranes and germathianes).

8.
Met Based Drugs ; 5(3): 139-46, 1998.
Article in English | MEDLINE | ID: mdl-18475835

ABSTRACT

Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds.

9.
Arch Toxicol ; 67(1): 66-71, 1993.
Article in English | MEDLINE | ID: mdl-8452483

ABSTRACT

A strategy is described to raise high-affinity antibodies directed against the organophosphorus nerve agent VX [O-ethyl S-(2-diisopropylamino)ethyl)methyl phosponothionate]. Ten chemical derivatives of VX (haptens) have been synthesized. Their structures differ principally from VX structure by substitution of S-atom by an O-atom or CH2-group and by introduction of a reactive group (carboxylic acid, arylamine or primary amine) on the O-ethyl side chain. None of these haptens, except one, exhibit potential toxicity as tested by their inhability to inhibit acetylcholinesterase (E.C. 3.1.1.7.). After coupling with a protein carrier, they were injected intradermally to rabbits. Nine of these immunogenic conjugates led to the appearance of antibodies able to bind VX in a competitive solid phase immunoassay. The apparent titer and affinity of the antisera differed greatly depending on the hapten used. The highest affinity (9 nM) was observed with the VX derivative bearing O-S substitution and O-ethyl-carboxylic side chains. The antibodies appear specific for VX, since cross-reactivity with other nerve agents (Soman, Sarin or Tabun) was low. However, two haptens elicited antibodies with affinity to Soman or Sarin in the micromolar range. Antibodies were able to neutralize VX inhibition of acetylcholinesterase in vitro but not in vivo.


Subject(s)
Antibodies/chemistry , Cholinesterase Inhibitors/immunology , Organothiophosphorus Compounds/immunology , Animals , Antibodies/immunology , Antibody Specificity , Cholinesterase Inhibitors/chemistry , Cross Reactions , Female , Haptens/chemistry , Haptens/immunology , Haptens/pharmacology , Immunoenzyme Techniques , Mice , Mice, Inbred BALB C , Neutralization Tests , Organothiophosphorus Compounds/chemistry , Organothiophosphorus Compounds/toxicity
SELECTION OF CITATIONS
SEARCH DETAIL
...