Automatic echocardiographic anomalies interpretation using a stacked residual-dense network model.

Echocardiographic interpretation during the prenatal or postnatal period is important for diagnosing cardiac septal abnormalities. However, manual interpretation can be time consuming and subject to human error. Automatic segmentation of echocardiogram can support cardiologists in making an initial interpretation. However, such a process does not always provide straightforward information to make a complete interpretation. The segmentation process only identifies the region of cardiac septal abnormality, whereas complete interpretation should determine based on the position of defect. In this study, we proposed a stacked residual-dense network model to segment the entire region of cardiac and classifying their defect positions to generate automatic echocardiographic interpretation. We proposed the generalization model with incorporated two modalities: prenatal and postnatal echocardiography. To further evaluate the effectiveness of our model, its performance was verified by five cardiologists. We develop a pipeline process using 1345 echocardiograms for training data and 181 echocardiograms for unseen data from prospective patients acquired during standard clinical practice at Muhammad Hoesin General Hospital in Indonesia. As a result, the proposed model produced of 58.17% intersection over union (IoU), 75.75% dice similarity coefficient (DSC), and 76.36% mean average precision (mAP) for the validation data. Using unseen data, we achieved 42.39% IoU, 55.72% DSC, and 51.04% mAP. Further, the classification of defect positions using unseen data had approximately 92.27% accuracy, 94.33% specificity, and 92.05% sensitivity. Finally, our proposed model is validated with human expert with varying Kappa value. On average, these results hold promise of increasing suitability in clinical practice as a supporting diagnostic tool for establishing the diagnosis.

CervicoXNet: an automated cervicogram interpretation network.

Visual inspection with acetic acid (VIA) is a pre-cancerous screening program for low-middle-income countries (LMICs). Due to the limited number of oncology-gynecologist clinicians in LMICs, VIA examinations are performed mainly by medical workers. However, the inability of the medical workers to recognize a significant pattern based on cervicograms, VIA examination produces high inter-observer variance and high false-positive rate. This study proposed an automated cervicogram interpretation using explainable convolutional neural networks named "CervicoXNet" to support medical workers decision. The total number of 779 cervicograms was used for the learning process: 487 with VIA ( +) and 292 with VIA ( -). We performed data augmentation process under a geometric transformation scenario, such process produces 7325 cervicogram with VIA ( -) and 7242 cervicogram with VIA ( +). The proposed model outperformed other deep learning models, with 99.22% accuracy, 100% sensitivity, and 98.28% specificity. Moreover, to test the robustness of the proposed model, colposcope images used to validate the model's generalization ability. The results showed that the proposed architecture still produced satisfactory performance, with 98.11% accuracy, 98.33% sensitivity, and 98% specificity. It can be proven that the proposed model has been achieved satisfactory results. To make the prediction results visually interpretable, the results are localized with a heat map in fine-grained pixels using a combination of Grad-CAM and guided backpropagation. CervicoXNet can be used an alternative early screening tool with VIA alone.