Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Bioorg Med Chem ; 21(23): 7392-7, 2013 Dec 01.
Article in English | MEDLINE | ID: mdl-24148834

ABSTRACT

The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC(50)s versus colon (HT29-AK and leukemia (HL60) cell lines.


Subject(s)
Antimalarials/chemistry , Antimalarials/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Caspase 3/metabolism , Tetraoxanes/chemistry , Tetraoxanes/pharmacology , Antimalarials/chemical synthesis , Antineoplastic Agents/chemical synthesis , Cell Line, Tumor , Dimerization , Humans , Malaria, Falciparum/drug therapy , Neoplasms/drug therapy , Plasmodium falciparum/drug effects , Tetraoxanes/chemical synthesis
SELECTION OF CITATIONS
SEARCH DETAIL
...