Prevalence and outcome of central airway obstruction in patients with lung cancer.

Introduction: Central airway obstruction (CAO) is a life-threatening complication of lung cancer. The prevalence of CAO in lung cancer patients is unknown. We audited CAO burden to inform our local cancer service. Methods: This is a cohort review of all new lung cancer diagnoses between 1 November 2014 and 30 November 2015. CAO was defined by CT appearance. CT scans and routine patient records were followed up to 30 November 2018 to determine the prevalence of CAO at diagnosis; the characteristics of patients with prevalent CAO; mortality (using survival analysis); and incident CAO over follow-up. Results: Of 342 new lung cancer diagnoses, CAO prevalence was 13% (95% CI 10% to 17%; n=45/342). Dedicated CT scan review identified missed CAO in 14/45 (31%) cases. In patients with prevalent CAO, 27/44 (61%) had a performance status of ≤2, 23/45 (51%) were diagnosed during an acute admission and 36/44 (82%) reported symptoms. Treatments were offered to 32/45 (71%); therapeutic bronchoscopy was performed in only 8/31 (26%) eligible patients. Median survival of patients with prevalent CAO was 94 (IQR 33-274) days. Multivariate analysis, adjusting for age, gender and disease stage, found CAO on index CT scan was independently associated with an increased hazard of death (adjusted HR 1.78 (95% CI 1.27 to 2.48); p=0.001). In total, 15/297 (5%) developed CAO during follow-up (median onset 340 (IQR 114-551) days). Over the audit period, 60/342 (18%; 95% CI 14% to 22%) had or developed CAO. Discussions: This is the first description of CAO prevalence in 40 years. Patients with prevalent CAO had a higher mortality. Our data provide a benchmark for service planning.

Diagnosing venous thromboembolism in pregnancy.

OBJECTIVE: We report the imaging outcomes of all pregnant patients referred for suspected thromboembolism over a 43-month period. METHODS: We identified 168 patients who underwent ventilation/perfusion (VQ) single-photon emission CT (SPECT), CT pulmonary angiography (CTPA) or a Doppler ultrasound scan of the lower legs, as well as a control group of 89 non-pregnant age- and sex-matched patients who underwent VQ SPECT during the same period. Imaging outcomes were recorded, and radiation doses were calculated for individual patients. RESULTS: VQ SPECT and CTPA were equally likely to diagnose pulmonary embolism (PE) in about one patient out of every seven patients investigated. One in three CTPA scans was of suboptimal quality. A Doppler ultrasound examination of the legs will find deep venous thrombosis much less often, in about 1 patient out of every 15 patients investigated. The prevalence of PE in pregnant patients (as diagnosed by VQ SPECT) was similar to that in the non-pregnant, age- and sex-matched control group. The effective dose and the absorbed radiation dose to the maternal breast were lower with VQ SPECT. The foetal dose is comparable for both VQ SPECT and CTPA. CONCLUSION: VQ SPECT and CTPA provide a similar diagnostic yield for diagnosing PE during pregnancy, but VQ SPECT does so with a lower radiation dose to the mother (effective dose and breast dose). ADVANCES IN KNOWLEDGE: Ours is the first report of the diagnostic performance of VQ SPECT, rather than planar VQ scans, in pregnancy in a routine clinical setting.

Image comparative assessment using iterative reconstructions: clinical comparison of low-dose abdominal/pelvic computed tomography between adaptive statistical, model-based iterative reconstructions and traditional filtered back projection in 65 patients.

OBJECTIVES: The objective of this study was to compare image quality (objective and subjective parameters) and confidence in lesion detection between 3 image reconstruction algorithms in computed tomographic (CT) examinations of the abdomen/pelvis. MATERIALS AND METHODS: This prospective institutional review board-approved study included 65 patients (mean [SD] age, 71.3 ± 9 years; mean [SD] body mass index, 24.4 [4.8] kg) who underwent routine CT examinations of the abdomen/pelvis followed immediately by 2 low-dose scans. Raw data sets were reconstructed by using filtered back projection (FBP), adaptive statistical iterative reconstruction (ASIR), and a model-based iterative reconstruction (MBIR). Measurements of objective noise and CT numbers were compared using repeated-measures analysis of variance. Six subjective image quality parameters were scored. Diagnostic confidence and accuracy in detection of various elementary lesions were performed. RESULTS: Objectively, mean image noise for MBIR was significantly superior at all dose levels (P < 0.001). Subjectively, standard-dose ASIR and low-dose MBIR scans were better than standard-dose FBP scan in all parameters assessed (P < 0.05). Low-dose MBIR scans were comparable with standard-dose ASIR scans in all parameters except at noise index of 70 (approximately 85% dose reduction), where, in this case, the detection of liver lesions less than 5 mm were rated inferior (P < 0.05) with diagnostic accuracy reducing to 77.4%. CONCLUSIONS: Low-dose MBIR scan shows superior objective noise reduction compared with standard-dose FBP and ASIR. Subjectively, low-dose MBIR scans at 76% dose reduction were also superior compared with standard-dose FBP and ASIR. However, at dose reductions of 85%, small liver lesions may be missed.

Lung herniation: an unusual cause of dysphagia.

Lung herniation is a rare condition that can be classified on the basis of location and etiology. We report an unusual case of right apical lung herniation presenting with dysphagia. Computed tomography of the neck demonstrated an air-containing structure in the root of the right side of the neck, related to but separate from the anteromedial aspect of the right lung apex. The diagnosis of an apical lung hernia was confirmed using high-resolution CT reconstructions. This case highlights that, although uncommon, apical lung hernias should always be considered when investigating abnormalities of swallowing. Identification of an apical lung hernia on plain chest radiographs avoids further unnecessary investigations and surgical intervention. Knowledge of their presentation may avoid complications that could arise from neck interventions such as subclavian central catheter insertion.

Image quality assessment of standard- and low-dose chest CT using filtered back projection, adaptive statistical iterative reconstruction, and novel model-based iterative reconstruction algorithms.

OBJECTIVE: The purpose of this article is to compare image quality between filtered back projection (FBP), adaptive statistical iterative reconstruction (ASIR), and model-based iterative reconstruction (MBIR) at standard dose and two preselected low-dose scans. SUBJECTS AND METHODS: Thirty patients (16 men and 14 women; mean age, 67 years) were prospectively recruited. Patients underwent three scans (one standard-dose scan and two low-dose scans at noise indexes [NIs] of 33, 60, and 70, respectively). All three scans were reconstructed with FBP, ASIR, and MBIR. Objective and subjective image qualities were compared. Dose-length products and effective doses for each scans were recorded. Mean image noise and attenuation values were compared between different reconstruction algorithms using repeated-measures analysis of variance and paired Student t tests. The interobserver variation between the two radiologists for subjective image quality and lesion assessment was estimated by using weighted kappa statistics. RESULTS: Objective image analysis supports significant noise reduction with low-dose scans using the MBIR technique (p < 0.05). There was no significant change in mean CT numbers between different reconstructions (p > 0.05). Subjective analysis reveals no significant difference between image quality and diagnostic confidence between low-dose MBIR scans compared with standard-dose scans reconstructed using ASIR (p > 0.05). Average effective doses were 3.7, 1.2, and 0.9 mSv for standard scans at NIs of 33, 60, and 70, respectively. CONCLUSION: MBIR shows superior noise reduction and improved image quality. Substantial dose reduction can be achieved by increasing the NI parameters as tested in this study without affecting image quality and diagnostic confidence.

Image Quality Assessment in Torso Phantom Comparing Effects of Varying Automatic Current Modulation with Filtered Back Projection, Adaptive Statistical, and Model-Based Iterative Reconstruction Techniques in CT.

OBJECTIVES: To compare image quality on computed tomographic (CT) images acquired with different levels of automatic tube current modulation reconstructed with filtered back projection (FBP), adaptive statistical iterative reconstruction (ASIR), and novel model-based iterative reconstruction (MBIR) techniques. METHODS: A torso phantom was scanned at 17 different noise levels of automatic current modulation and images were reconstructed with FBP, ASIR, and MBIR. Objective and subjective image qualities were assessed. Effective dose was also calculated. RESULTS: Objective image analysis supports significant noise reduction and superior contrast to noise ratio with new a MBIR technique. Subjective image parameters were maximally rated for MBIR followed by ASIR then FBP. The reconstruction algorithms were evaluated over effective doses ranging from 0.7 to 3 mSv. CONCLUSION: MBIR shows superior reduction in noise and improved image quality (both objective and subjective analysis) compared with ASIR and FBP. It was possible to achieve meaningful image quality even at the highest noise index of 70 achieving substantial dose reduction to as low as 0.7 mSv.