ABSTRACT
OBJECTIVE: To evaluate the incidence of adverse reactions to first and second bacille Calmette-Guérin (BCG) vaccination in schoolchildren. SETTING AND DESIGN: Enhanced surveillance in a Brazilian trial. Suspected reactions were reported to a nurse who visited cases and completed a standard form. RESULTS: Among 71341 schoolchildren studied, 33 reactions were reported. Of these, 25 fulfilled the criteria, resulting in a rate of one per 2854 vaccinations, with no deaths or BCG-osis. Reactions to second doses were more common than to first BCG vaccinations, but this difference was not statistically significant. CONCLUSIONS: Adverse reactions to a second dose of BCG may be more frequent than reactions to a first dose, but they are still rare events.
Subject(s)
BCG Vaccine/adverse effects , Mass Vaccination/adverse effects , Tuberculosis, Pulmonary/prevention & control , Adolescent , BCG Vaccine/administration & dosage , Brazil/epidemiology , Child , Cohort Studies , Dose-Response Relationship, Drug , Erythema/chemically induced , Erythema/epidemiology , Female , Fever/chemically induced , Fever/epidemiology , Humans , Hypersensitivity, Immediate/chemically induced , Hypersensitivity, Immediate/epidemiology , Immunization Schedule , Lymphadenitis/chemically induced , Lymphadenitis/epidemiology , Male , Prevalence , Prognosis , Registries , Risk Assessment , Skin Ulcer/chemically induced , Skin Ulcer/epidemiology , StudentsABSTRACT
Gorlin's syndrome is a relatively rare generalized disorder. Its diagnosis in childhood is usually through oral abnormalities. Some of the most frequent clinical features of this syndrome are discovered through radiographs commonly used in orthodontia. Thus, the orthodontist may be able to contribute to its diagnosis. The article shows three clinical cases that illustrate the role that the orthodontist may play in diagnosis of this syndrome.
