ABSTRACT
Glioblastoma is most commonly a primary brain tumor and the utmost malignant one, with a survival rate of approximately 12-18 months. Glioblastoma is highly heterogeneous, demonstrating that different types of cells from the same tumor can manifest distinct gene expression patterns and biological behaviors. Conventional therapies such as temozolomide, radiation, and surgery have limitations. As of now, there is no cure for glioblastoma. Alternative treatment methods to eradicate glioblastoma are discussed in this review, including targeted therapies to PI3K, NFKß, JAK-STAT, CK2, WNT, NOTCH, Hedgehog, and TGFß pathways. The highly novel application of oncolytic viruses and nanomaterials in combating glioblastoma are also discussed. Despite scores of clinical trials for glioblastoma, the prognosis remains poor. Progress in breaching the blood-brain barrier with nanomaterials and novel avenues for targeted and combination treatments hold promise for the future development of efficacious glioblastoma therapies.
ABSTRACT
Pancreatic cancer (PanCa) is one of the most aggressive forms of cancer and its incidence rate is continuously increasing every year. It is expected that by 2030, PanCa will become the 2nd leading cause of cancer-related deaths in the United States due to the lack of early diagnosis and extremely poor survival. Despite great advancements in biomedical research, there are very limited early diagnostic modalities available for the early detection of PanCa. Thus, understanding of disease biology and identification of newer diagnostic and therapeutic modalities are high priority. Herein, we have utilized high dimensional omics data along with some wet laboratory experiments to decipher the expression level of hormone receptor interactor 13 (TRIP13) in various pathological staging including functional enrichment analysis. The functional enrichment analyses specifically suggest that TRIP13 and its related oncogenic network genes are involved in very important patho-physiological pathways. These analyses are supported by qPCR, immunoblotting and IHC analysis. Based on our study we proposed TRIP13 as a novel molecular target for PanCa diagnosis and therapeutic interventions. Overall, we have demonstrated a crucial role of TRIP13 in pathogenic events and progression of PanCa through applied integrated computational biology approaches.
ABSTRACT
Oil spill in the Central Patagonian zone was studied to evaluate if any relationship exists between the parameters used to characterize weathering spilled oil and soil toxicity for two plant species and to evaluate if the phytotoxicity to local species would be a good index for the soil contamination. Nuclear magnetic resonance (NMR) structural indexes and column chromatography compositional indexes were determined to characterize the oil spill in the soil samples. Bioassays were also carried out using Lactuca sativa L (reference) and Atriplex lampa (native species) as test organisms. Measurements of the total petroleum hydrocarbon (TPH) and the electrical conductivity (EC) of the soil were carried out to evaluate the effect on the bioassays. The principal components analysis of the parameters determined by NMR, compositional indexes, EC, TPH, and toxicology data shows that the first three principal components accounted for the 78% of the total variance (40%, 25%, and 13% for the first, second, and third PC, respectively). A good agreement was found between information obtained by compositional indexes and NMR structural indexes. Soil toxicity increases with the increase of EC and TPH. Other factors, such as, the presence of branched and aromatic hydrocarbons is also significant. The statistical evaluation showed that the Euclidean distances (3D) between the background and each one of the samples might be a better indicator of the soil contamination, compared with chemical criterion of TPH.
Subject(s)
Hydrocarbons/chemistry , Magnetic Resonance Spectroscopy/methods , Petroleum Pollution/analysis , Petroleum/analysis , Petroleum/toxicity , Argentina , Germination/drug effects , Hydrocarbons/analysis , Hydrocarbons/toxicity , Soil/chemistryABSTRACT
Se estudio la incidencia de petroleo en suelo sobre la etapa de germinacion de la especie vegetal Grindella chiloensis, comun en la Patagonia argentina, ante dos situacione distintas: caso de contaminacion directa con germinacion en suelos con diferentes contenidos de petroleo, y contaminacion indirecta con germinacion en suelos regados con agua que contiene la fraccion soluble del petroleo
Subject(s)
Argentina , Environmental Pollution , Flora , Hydrocarbons , Petroleum , SoilABSTRACT
Se estudio la incidencia de petroleo en suelo sobre la etapa de germinacion de la especie vegetal Grindella chiloensis, comun en la Patagonia argentina, ante dos situacione distintas: caso de contaminacion directa con germinacion en suelos con diferentes contenidos de petroleo, y contaminacion indirecta con germinacion en suelos regados con agua que contiene la fraccion soluble del petroleo
Subject(s)
Argentina , Flora , Hydrocarbons , Petroleum , Environmental Pollution , SoilABSTRACT
Define y clasifica los modelos ambientales, y señala las características fisicoquímicas que consideran. Explica los modelos ambientales estocásticos, e indica su aplicación a derrames de petróleo en ecosistemas terrestres. Sugiere su uso en los estudios de factibilidad de los proyectos de ingeniería
Subject(s)
Environment , Environmental Models , Environmental Pollution , Oil and Gas Industry , Environment DesignABSTRACT
Define y clasifica los modelos ambientales, y señala las características fisicoquímicas que consideran. Explica los modelos ambientales estocásticos, e indica su aplicación a derrames de petróleo en ecosistemas terrestres. Sugiere su uso en los estudios de factibilidad de los proyectos de ingeniería
