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Neurology ; 48(5): 1421-7, 1997 May.
Article in English | MEDLINE | ID: mdl-9153484

ABSTRACT

OBJECTIVE: To compare the effectiveness of two regimens of albendazole therapy for neurocysticercosis. DESIGN: Randomized, double-blind clinical trial. SETTINGS: Patients admitted to neurologic wards in Lima, Peru. PATIENTS: Adult patients with active neurocysticercosis demonstrated by CT and Western blot (immunoblot). INTERVENTION: One week (n = 25) versus 2 weeks (n = 25) of albendazole therapy. MEASUREMENTS: Decrease in the number of cysts on CT. RESULTS: Effectiveness of albendazole was 78%, with no difference between the groups when compared 3 months after therapy. Complete cure was obtained in only 38% of patients. Patients with more than 20 cysts had poorer responses to therapy. The clinical course and EEG evolution improved in most patients. Side effects were present in 38% of patients, mainly mild, transient gastrointestinal symptoms. Therapy was also associated with exacerbation of neurologic symptoms. Two patients died in the first year after therapy, both because of aggregated infections of ventricle-peritoneal shunts. One-year follow-up CT showed lesions in three of 10 patients presumed to be cured 3 months after therapy. CONCLUSIONS: Extension of albendazole therapy for more than 7 days adds no benefits for the patients.


Subject(s)
Albendazole/therapeutic use , Anthelmintics/therapeutic use , Brain Diseases/drug therapy , Cysticercosis/drug therapy , Adult , Albendazole/adverse effects , Anthelmintics/adverse effects , Brain Diseases/diagnostic imaging , Brain Diseases/physiopathology , Cysticercosis/diagnostic imaging , Cysticercosis/physiopathology , Double-Blind Method , Electroencephalography , Female , Follow-Up Studies , Humans , Male , Middle Aged , Prospective Studies , Tomography, X-Ray Computed , Treatment Outcome
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