ABSTRACT
Of the 9300 bone marrows and peripheral bloods analyzed for hematologic disease in our laboratory between 1978 and 1990, 240 patients exhibited X or Y loss of chromosomes. Of those 240 patients only two could be positively associated with acute leukemia and no other observable chromosome involvement. The evidence presented here, albeit represented by only two patients, proves that sex chromosome loss as the sole abnormality can be a clonal cytogenetic marker for acute leukemia. One patient was a 48-year-old man with loss of the Y in 93% of his bone marrow metaphases and the other patient was a 53-year-old woman with 100% loss of the X in her bone marrow metaphases (perhaps the first such report of a woman). After therapy, both remission bone marrow analyses showed complete reappearance of the respective sex chromosomes.
Subject(s)
Chromosome Aberrations , Leukemia, Myeloid, Acute/genetics , Monosomy , X Chromosome , Y Chromosome , Female , Humans , Male , Middle AgedABSTRACT
We have identified three patients with acute nonlymphocytic leukemia (ANLL), subtypes M2, M4, and M7, who had a t(16;21)(p11.2;q22) in the affected cells. There are six previously reported cases of ANLL with the same t(16;21). The t(6;21) should therefore be included as another primary rearrangement in ANLL. Follow-up of these cases, though still limited, suggests a poor prognosis, as most patients have achieved a clinical remission but only for a short duration.
