[The effect of metronidazole on the radiosensitivity of cancer of the uterine cervix]. / Vliianie metronidazola na radiochuvstvitel'nost' raka sheiki matki.

A comparative study of the effect of rectal administration of metronidazole on radiosensitivity of cervical cancer with relation to tumor sizes and a Hb level was conducted. The effect of a direct tumor reaction on survival was investigated. Rectal administration of metronidazole proved to be effective in large tumor sizes and a low Hb level. The use of metronidazole resulted in an increase in the number of patients with complete tumor regression and an increase in their survival. A low Hb level is an independent prognostic factor in radiation therapy of cervical cancer leading to an increase in tumor radiosensitivity.

[Intratumoral and parametric administration of metronidazole in the radiotherapy of cancer of the cervix]. / Vnutriopukholevoe i parametral'noe vvedenie metronidazola pri luchevoi terapii raka sheiki matki.

The paper is concerned with analysis of the results of radiation therapy of cervical cancer and intratumoral administration of metronidazole (124 patients with tumors, Stage IIB and III). At the end of the treatment, complete tumor regression in the intervention group (with metronidazole) was noted in 91% (irrespective of a stage of disease), in the control group (without metronidazole)--in 51% of the patients.

[Hemoglobin level--a prognostic factor of the effectiveness of metronidazole in radiotherapy of cancer of the cervix uteri]. / Gemoglobin krovi--prognosticheskii faktor éffektivnosti metronidazola pri luchevoi terapii raka sheiki matka.

A clinical trial was performed in 339 patients with Stages IIB, IIIB cervical carcinoma to test the effect of radiotherapy in combination with metronidazole. When the overall material was evaluated, no significant difference in the local clearance rate of tumors in metronidazole-treated and untreated patients was revealed. However, when the case material was subdivided into a group of anemic patients (hemoglobin less than 120 g/l) and a group of patients with normal hemoglobin levels (hemoglobin greater than 120 g/l) the data indicated that metronidazole therapy improved significantly the results in the anemic patients. The results in the non-anemic patients were not influenced, to any significant extent, by the drug.

[Pathomorphosis of cervical cancer with different methods of radiation treatment]. / Patomorfoz raka sheiki matki pri razlichnykh metodakh luchevogo lecheniia.

The report deals with a comparison of the results of cytologic and clinical evaluation of the effectiveness of different methods of radiotherapy in 93 cases of cervical carcinoma. A correlation established between cytologic data and clinical manifestations suggested that cytologic procedures be used as a criterion for ascertaining tumor radiosensitivity. The advantages offered by application of modifiers of tumor radiosensitivity are discussed.