ABSTRACT
BACKGROUND: Topical tazarotene has been shown to offer efficacy in ameliorating multiple effects of photodamage. OBJECTIVES: To evaluate the histological effects of tazarotene cream on photodamaged skin. METHODS: In this multicentre, double-blind, randomized, vehicle-controlled study, 50 patients with photodamaged facial skin (at least mild fine wrinkling and mottled hyperpigmentation, with at least one of these being moderate) were randomized to apply tazarotene 0.1% cream or vehicle cream to their face, once daily for 24 weeks. RESULTS: Blinded assessments showed that tazarotene was less likely than vehicle to be associated with an increase in keratinocytic and melanocytic atypia, and more likely than vehicle to be associated with a reduction in atypia. Between-group comparisons in distribution of change from baseline categories of severity were in favour of tazarotene (P = 0.055 for keratinocytic atypia, P = 0.034 for melanocytic atypia, and P < 0.001 for the number of granular cell layers). Compared with vehicle, tazarotene was associated with an increase in epidermal polarity (P = 0.008) and epidermal thickness (P = 0.012), and a tendency for stratum corneum compaction. Tazarotene was also associated with widened intercellular spaces (reported as epidermal oedema) relative to vehicle (P < 0.001). CONCLUSIONS: Treatment of photodamaged skin with tazarotene is associated with an amelioration of keratinocytic and melanocytic atypia, an improvement in epidermal polarity, and an increase in epidermal thickness.
Subject(s)
Facial Dermatoses/drug therapy , Hyperpigmentation/drug therapy , Keratolytic Agents/therapeutic use , Nicotinic Acids/therapeutic use , Skin Aging/drug effects , Adult , Aged , Double-Blind Method , Facial Dermatoses/pathology , Female , Humans , Hyperpigmentation/pathology , Keratinocytes/pathology , Keratolytic Agents/adverse effects , Male , Melanocytes/pathology , Middle Aged , Nicotinic Acids/adverse effects , Pharmaceutical Vehicles/adverse effects , Pharmaceutical Vehicles/therapeutic use , Severity of Illness Index , Skin Aging/pathology , Treatment OutcomeABSTRACT
Granuloma fissuratum is a reactive process of the skin usually caused by chronic trauma from ill-fitting eyeglass frames. Its clinical resemblance to malignant tumors makes it important to recognize this benign condition. This case report discuses the diagnosis and management of granuloma fissuratum.
Subject(s)
Granuloma/diagnosis , Skin Diseases/diagnosis , Skin Neoplasms/diagnosis , Diagnosis, Differential , Eyeglasses , Granuloma/etiology , Humans , Male , Middle Aged , Skin Diseases/etiologyABSTRACT
A case of tinea of the pinna, mistaken for chondritis, is presented. Chondritis should be added to the list of diseases that tinea infection may mimic.
Subject(s)
Cartilage Diseases , Ear Cartilage , Ear, External , Tinea/diagnosis , Adult , Cartilage Diseases/diagnosis , Diagnosis, Differential , Ear Diseases/diagnosis , Ear, External/pathology , Female , Humans , Steroids/therapeutic use , Tinea/drug therapy , Tinea/pathologyABSTRACT
Anetoderma is a rare cutaneous condition with characteristic clinical features and histopathology. The condition is classified into idiopathic (Jadassohn or Pellizzari type) and atrophic (Schweinger-Buzzi type) concomitant with other diseases, and secondary to infection or drugs.
Subject(s)
Skin Diseases/pathology , Atrophy , Female , Humans , Middle Aged , Skin/pathologyABSTRACT
Toxic epidermal necrolysis consists of two distinct clinical entities. The Ritter type, seen mostly in children under age 10, is the severest manifestation of staphylococcal disease. A toxin has been isolated which is postulated to be the cause for clinical lesions. High epidermal necrosis occurs. Treatment is with one of the penicillinase-resistant penicillins, and prognosis is good. The Lyell type is seen mostly in adults, is drug-related, and may be the severest form of the Stevens-Johnson syndrome. Full-thickness epidermal necrosis occurs. Treatment consists of withdrawing the offending drug. Good nursing care is essential. Prognosis is guarded.
