Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Br J Haematol ; 191(1): 107-114, 2020 10.
Article in English | MEDLINE | ID: mdl-32427352

ABSTRACT

We longitudinally evaluated the effects of regular blood transfusions (BTs), in the real-life context of the Myocardial Iron Overload in Thalassaemia network, in patients with thalassaemia intermedia (TI). We considered 88 patients with TI (52 females) who started regular BTs after the age of 18 years. Magnetic resonance imaging was used to quantify iron overload and biventricular function. For 56·8% of the patients there were more than two indications for the transition to regular BTs, with anaemia present in 94·0% of the cases. A significant decrease in nucleated red blood cells, platelets, lactate dehydrogenase, bilirubin, and uric acid levels was detected 6 months after starting regular BTs. After the transition to the regular BT regimen there was a significant increase only in the frequency of hypothyroidism and osteopenia, and a significant decrease in liver iron and cardiac index. The percentage of chelated patients increased significantly after starting regular BTs. The decision to regularly transfuse patients with TI may represent a way to prevent or slow down the natural progression of the disease, despite the more complex initial management.


Subject(s)
Blood Transfusion , Magnetic Resonance Imaging , beta-Thalassemia , Adolescent , Adult , Aged , Bilirubin/blood , Blood Platelets/metabolism , Bone Diseases, Metabolic/blood , Bone Diseases, Metabolic/etiology , Child , Erythroblasts/metabolism , Female , Follow-Up Studies , Humans , Hypothyroidism/blood , Hypothyroidism/etiology , L-Lactate Dehydrogenase/blood , Longitudinal Studies , Male , Middle Aged , Uric Acid/blood , beta-Thalassemia/blood , beta-Thalassemia/diagnostic imaging , beta-Thalassemia/therapy
SELECTION OF CITATIONS
SEARCH DETAIL
...