[Serum reactivity of antigen fractions of atypical mycobacteria in patients with lung diseases]. / Serumreaktivität von Antigenfraktionen aus atypischen Mykobakterien (MOTT) bei Lungenerkrankungen.

In connection with studies on the pathogenesis of sarcoidosis antigen fractions were isolated from 8 mycobacteria species, three out of each strain. These fractions were tested for their reactivity to serum antibodies by means of RIA-technique, using 40 selected sera from controls, and patients with sarcoidosis, tuberculosis and asthma. Comparing the results (average titer steps) sera from asthmatics showed the lowest and those from sarcoidosis patients the highest reactivities to the mycobacterial antigen fractions. The reactivities clearly differed in dependence on the mycobacteria species. The highest mean reactivity in sarcoidosis patients was found with the HIP-antigen fraction of M. xenopi. It was 8 times higher compared to the control sera as well as the tuberculosis sera and 32 times higher than that of the asthma sera. There were also clear differences in the reactivities within the sarcoidosis sera tested. In sera from patients with clinically inactive sarcoidosis there were found nearly the same or only slightly higher titer steps than in control sera as well as tuberculosis sera, however in clinically active sarcoidosis the titer steps were clearly elevated. The findings are seen in connection with the role of atypical mycobacteria (MOTT) in the pathogenesis of sarcoidosis. The potential applications of the HIP- and Triton X-100 antigen fractions for in vitro diagnostics are discussed.

[Identification of mycobacteria under routine clinical conditions]. / Artbestimmung von Mykobakterien unter Routinebedingungen.

A simplified system for identification of mycobacteria in routine is presented and discussed. By this way costs for staff and material can be reduced.

The influence of hypoxia and hyperoxia during metabolic acidosis and alkalosis on pulmonary haemodynamics.

In anaesthetised, mechanically ventilated Beagle dogs a moderate metabolic acidosis increased the pulmonary vascular resistance to a greater extent than moderate hypoxia. Alkalosis and hyperoxia did not alter the pulmonary vascular tone.

[Animal experiment studies of morphologic changes in the trachea and lung in high frequency ventilation]. / Tierexperimentelle Untersuchungen zu morphologischen Veränderungen an Trachea und Lunge bei Hochfrequenzbeatmung.

Prolonged high frequency ventilation (24 hrs) in dogs leads to morphological changes in the trachea as well as in the bronchi. Erosive changes of tracheal epithelium were observed whereas small bronchi and bronchioli exhibited luminal obstructions by mucus plugs, caused by hypersecretion of goblet cells. Using histochemical methods degenerative changes of bronchiolar epithelium were observed.