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3.
An Esp Pediatr ; 35(1): 45-9, 1991 Jul.
Article in Spanish | MEDLINE | ID: mdl-1663321

ABSTRACT

As children with cancer survive longer, the incidence of second malignant neoplasms has increased considerably. We describe here three cases of second solid tumors after 12, 8 and 2 years of initial diagnosis of cancer: one osteosarcoma of left maxilla in a previously treated child with bilateral retinoblastoma, a temporal astrocytoma associated with acute lymphoblastic leukemia and a glioblastoma multiforme in a girl with neurofibromatosis de Von Recklinghausen, after Non Hodgkin lymphoma, respectively. We review the literature about the influence of genetic, immunologic and therapeutic factors involved in the appearance of these second tumors.


Subject(s)
Neoplasms, Second Primary/genetics , Astrocytoma/genetics , Astrocytoma/immunology , Astrocytoma/therapy , Child , Female , Glioblastoma/genetics , Glioblastoma/immunology , Glioblastoma/therapy , Hodgkin Disease/genetics , Hodgkin Disease/immunology , Hodgkin Disease/therapy , Humans , Infant , Lymphoma, Non-Hodgkin/genetics , Lymphoma, Non-Hodgkin/immunology , Lymphoma, Non-Hodgkin/therapy , Male , Maxillary Neoplasms/genetics , Maxillary Neoplasms/immunology , Maxillary Neoplasms/therapy , Neoplasms, Second Primary/immunology , Neoplasms, Second Primary/therapy , Neurofibromatosis 1/genetics , Neurofibromatosis 1/immunology , Neurofibromatosis 1/therapy , Osteosarcoma/genetics , Osteosarcoma/immunology , Osteosarcoma/therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy , Retinoblastoma/genetics , Retinoblastoma/immunology , Retinoblastoma/therapy
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