ABSTRACT
La odontalgia aguda es un motivo frecuente de consultas en urgencias de atención primaria, especialmente fuera del horario de trabajo de los odontólogos. Ante la aparición cada vez más frecuente de efectos secundarios asociados a la medicación utilizada habitualmente en los cuadros de odontalgia aguda, se planteó como objetivo comprobar si la aplicación tópica de aceite esencial de clavo (Syzygium aromaticum (L) Merill et L.M. Perry) resultaba al menos tan eficaz como el tratamiento habitual con analgésicos y/o antiinflamatorios. Participaron 96 pacientes, de los cuales 52 fueron tratados tópicamente con aceite esencial de clavo y 44 (grupo control) con metamizol o diclofenaco intramuscular. La intensidad del dolor fue evaluada por los pacientes a través de la escala analógica visual antes y después del tratamiento. Los resultados no mostraron diferencias entre ambos tratamientos en cuanto a la reducción del dolor, si bien con el aceite esencial se consiguió el efecto en menos de 5 minutos, en comparación con los 45-60 minutos necesarios con metamizol o diclofenaco. (AU)
A odontalgia aguda é motivo frequente de visitas às urgências, principalmente fora do horário de trabalho do dentista. Perante o aparecimento cada vez mais frequente de efeitos colaterais associados aos medicamentos comumente utilizados na situação de odontologia aguda, o objetivo foi verificar se a aplicação tópica do óleo essencial de cravinho (Syzygium aromaticum (L) Merill et LM Perry) foi pelo menos tão eficaz quanto o tratamento usual com analgésicos e/ou antiinflamatórios. Participaram 96 pacientes, dos quais 52 foram tratados topicamente com óleo essencial de cravinho e 44 (grupo controle) com metamizol ou diclofenac intramusculares. A intensidade da dor foi avaliada pelos pacientes por meio da escala visual analógica antes e após o tratamento. Os resultados não mostraram diferenças entre os dois tratamentos em termos de redução da dor, embora o óleo essencial tenha alcançado o efeito em menos de 5 minutos, em comparação com os 45-60 minutos necessários com metamizol ou diclofenac. (AU)
Acute dental pain is a frequent reason for consultations in primary care emergencies, especially outside the dentists working hours. Given the increasingly frequent appearance of side effects associated with the medication commonly used in acute toothache, the objective was to check whether the topical application of the essential oil of clove (Syzygium aromaticum (L) Merill et LM Perry) was at least as effective as the usual treatment with analgesics and/or anti-inflammatory drugs. Ninety-six patients participated: 52 were treated topically with clove essential oil and 44 (control group) with intramuscular metamizole or diclofenac. The intensity of pain was evaluated by the patients through the visual analog scale, before and after the treatment. The results did not show differences between the two treatments in terms of pain reduction, although the essential oil achieved the effect in less than 5 minutes, compared to the 45-60 minutes required with metamizole or diclofenac. (AU)
Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Adult , Middle Aged , Aged , Aged, 80 and over , Toothache , Oils, Volatile/pharmacology , Emergencies , Anti-Inflammatory Agents, Non-Steroidal , Analgesics , SyzygiumABSTRACT
La incorporación de plantas como parte del cuidado de la salud y de la prevención y el tratamiento de enfermedades en el grupo familiar, y su aplicación en la población pediátrica, depende del origen cultural de la familia y el niño; influenciado a su vez por las características de la comunidad donde habita. Lo que determina el uso o no de plantas medicinales, la variedad y el reconocimiento de las especies utilizadas y las formas de aplicación sobre la población. El conocimiento por parte de los profesionales de la salud, sobre las plantas medicinales utilizadas en las zonas sanitarias donde ejerce, evitaría o disminuiría los posibles efectos adversos. ademas lograría intercambiar saberes con los pacientes, respetando su acervo cultural. Al integrar los conocimientos tradicional y científico las medicinas actúan en forma complementaria, perfeccionándose mutuamente con el fin de ayudar al paciente.
Subject(s)
Humans , Plants, Medicinal , Child Health , Argentina , Rural Population , Phytotherapy , Medicine, TraditionalABSTRACT
BACKGROUND: The development of biomarkers for use in diagnosing, monitoring disease progression and analyzing therapeutic trials response in amyotrophic lateral sclerosis (ALS) is essential. OBJECTIVE: The aim of this study was to identify inflammatory factors in plasma or cerebrospinal fluid (CSF) from patients with ALS with particular attention to specific markers of microglia activation as chitotriosidase (ChT) and chemokine (C-C motif) ligand 18 (CCL18) to determine its potential as ALS biomarkers. METHODS: We studied CSF and plasma samples from 32 patients and 42 healthy controls. We assayed the ChT activity by a spectrofluorometric method and protein levels of other inflammatory -biomarkers (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6 and CCL18) by enzyme-linked immunosorbent assay. CHIT1 gene polymorphism in exon 10 (c.1049_1072dup24) encoding inactive ChT enzyme was genotyped in all subjects. RESULTS: ChT activity and TNF-alpha protein levels were significantly higher in CSF of ALS patients, but we found no correlation with the severity and progression of the disease. Nevertheless, we did not found any differences in CCL18 or IL-6 protein levels between both groups in CSF or plasma. In our sample, only 3% of subjects were homozygous carriers for the CHIT1 exon 10 duplication associated with defective enzyme. CONCLUSIONS: High ChT activity in CSF of patients with ALS may reflect microglia activation and could be a potential biomarker of the disease. We did not find any significant difference regarding CCL-18, another specific marker of microglia activation that is related with M2-like microglia phenotype. Deepening the understanding of the activation state of microglia (M1 and M2) may contribute to the knowledge about the specific role of neuroinflammation in ALS and future therapeutic strategies.
