Subject(s)
Bronchiolitis Obliterans Syndrome , Graft vs Host Disease , Hematopoietic Stem Cell Transplantation , Lymphoma, T-Cell, Cutaneous , Humans , Neoplasm Recurrence, Local , Nitriles , Lymphoma, T-Cell, Cutaneous/drug therapy , Graft vs Host Disease/drug therapy , Graft vs Host Disease/etiology , Retrospective Studies , Chronic DiseaseABSTRACT
A 75 years old patient presented with a papular easily bleeding lesion of the lower lip that had been growing for two months. He was known for alcoholic cirrhosis complicated with hepatocellular carcinoma treated since one year. A working diagnostic hypothesis of benign vascular lesion was proposed. Microscopic examination showed a neoplastic dermal proliferation that had been fully excised, made of lobules segregated by thin fibrous septae. The neoplastic architecture was trabecular and delineating spaces forming pseudo-rosettes. Tumour cells were monomorphic, cuboidal or cylindric with abundant eosinophilic and granulous cytoplasm and centered by a lone nucleus that often contained a prominent nucleolus. Some spaces were filled with a brownish-greenish pigmented material. Immunohistochemical study showed that tumour cells were positive with the hepatocyte paraffin 1 antibody as well as cytokeratin 8 antibody. Chromogranin A and synaptophysin stainings were negative. Thus we concluded to a lip metastasis from the previously known hepatocellular carcinoma. Skin metastasis arise in around 3% of cases of hepatocellular carcinoma. They account for less than 1% of all cutaneous metastasis. Overall appearance of cutaneous metastasis of hepatocellular carcinoma is associated with a poor prognosis and an aggravated risk of metastasis to other locations and organs and a median overall survival of less than 5 months. Since incidence of hepatocellular carcinoma is rising pathologists might face more frequently in years to come to cutaneous metastasis whose varied clinical presentations make a diagnostic challenge.
Subject(s)
Carcinoma, Hepatocellular , Liver Neoplasms , Skin Neoplasms , Male , Humans , Aged , Carcinoma, Hepatocellular/pathology , Skin Neoplasms/pathology , Immunohistochemistry , Antibodies , Liver Neoplasms/pathologySubject(s)
Lymphoma, Large-Cell, Anaplastic , Mycosis Fungoides , Skin Neoplasms , Humans , Lymphoma, Large-Cell, Anaplastic/drug therapy , Lymphoma, Large-Cell, Anaplastic/pathology , Mycosis Fungoides/pathology , Antibodies, Monoclonal, Humanized/adverse effects , Skin Neoplasms/pathology , Ki-1 AntigenSubject(s)
Mycosis Fungoides , Sezary Syndrome , Skin Neoplasms , Humans , Prognosis , Cell Transformation, NeoplasticSubject(s)
Lymphoma, T-Cell, Cutaneous , Mycosis Fungoides , Skin Neoplasms , Humans , Lymphoma, T-Cell, Cutaneous/diagnosis , Lymphoma, T-Cell, Cutaneous/therapy , Lymphoma, T-Cell, Cutaneous/pathology , Mycosis Fungoides/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/therapy , Skin Neoplasms/pathology , Skin/pathology , PrognosisABSTRACT
is missing (Short communication).
Subject(s)
Hodgkin Disease , Lupus Erythematosus, Cutaneous , Lupus Erythematosus, Discoid , Lymphoma, B-Cell, Marginal Zone , Skin Neoplasms , Humans , Lupus Erythematosus, Cutaneous/diagnosis , Lupus Erythematosus, Cutaneous/drug therapy , Lymphoma, B-Cell, Marginal Zone/diagnosis , Skin Neoplasms/diagnosisSubject(s)
Mycosis Fungoides , Skin Neoplasms , Aged , Anticarcinogenic Agents/therapeutic use , Bexarotene , Depsipeptides/therapeutic use , Humans , Male , Middle Aged , Mycosis Fungoides/diagnosis , Mycosis Fungoides/drug therapy , Mycosis Fungoides/pathology , Photosensitivity Disorders/diagnosis , Skin Neoplasms/diagnosis , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Tetrahydronaphthalenes/therapeutic useSubject(s)
Graft vs Host Disease/immunology , Interleukin-17/metabolism , Psoriasis/metabolism , Th1 Cells/cytology , Th17 Cells/cytology , CD4-Positive T-Lymphocytes/cytology , CD8-Positive T-Lymphocytes/cytology , Graft vs Host Disease/therapy , Hematopoietic Stem Cell Transplantation/adverse effects , Humans , Interferon-gamma/metabolism , Interleukin-10/metabolism , Keratinocytes/cytology , Lung/immunology , Lymphocytes/cytology , Male , Middle Aged , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy , Remission Induction , Skin/immunology , Skin/pathologyABSTRACT
Eccrine porocarcinoma is a rare malignant sweat gland tumor, representing less than 0.01% of all cutaneous neoplasms, with eccrin differentiation. Its acrosynringeal origin and physiopathology still remain discussed. The prognosis of this carcinoma is held to be poor with a significant risk of lymph node metastasis and local recurrence. Also, this not specific tumor can be a challenging histological diagnosis, in particular, in Bowenoid variant. We report a case of Bowenoid and keratinizing variant of eccrine porocarcinoma of the left ring finger with pejorative evolution and initial diagnosis of infiltrating squamous cell carcinoma arising in Bowen's disease. The knowledge of these patterns and identification of eccrine differentiation of the tumor are essential for the diagnosis and for adapted therapeutic care.
Subject(s)
Bowen's Disease/pathology , Eccrine Porocarcinoma/pathology , Skin Neoplasms/pathology , Sweat Gland Neoplasms/pathology , Aged, 80 and over , Biomarkers, Tumor/analysis , Female , Fingers , Humans , Immunohistochemistry , Lymphatic Metastasis , Neoplasm Recurrence, Local , PrognosisABSTRACT
BACKGROUND: A rare variant of mycosis fungoides (MF), syringotropic MF (STMF) is characterized by a particular tropism of the lymphocytic infiltrate for the eccrine structures, and included in the follicular subtype of MF in the World Health Organization-European Organization for Research and Treatment of Cancer classification of cutaneous lymphomas. OBJECTIVE: We sought to determine the clinicopathologic features and disease course of patients with STMF. METHODS: A retrospective study was conducted to identify patients with STMF from 1998 to 2013. RESULTS: Nineteen patients were included: 15 men and 4 women, mean age 55 years (range, 24-86). Most had multiple lesions (n=16, 84%) with associated alopecia (n=12, 63%) and/or punctuated aspect (n=12, 63%). Palms or soles were involved in 10 cases (53%). Folliculotropism was found in 13 cases (68%). After a median follow-up of 70 months (range, 2-140), 3 patients died, 1 from disease-related death. The 5-year overall and disease-specific survival were 100%. The disease-specific survival was significantly higher than in 54 patients with folliculotropic MF without syringotropism (5-year disease-specific survival, 74%; 95% confidence interval, 58%-94%, P=.02). LIMITATIONS: Retrospective setting is a limitation. CONCLUSIONS: In the spectrum of adnexotropic MF, STMF appears as a distinct entity from follicular MF, with peculiar clinical characteristics and natural history.