Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Planta Med ; 73(4): 355-62, 2007 Apr.
Article in English | MEDLINE | ID: mdl-17511060

ABSTRACT

A contribution of the volatile oil from ginger rhizomes (Zingiber officinale Roscoe) on inhabiting the 5-HT3 receptor complex had been shown. In the present study a possible interaction of some compounds of the volatile oil with the 5-HT3 receptor system expressed in N1E-115 cells and with the serotoninergic system of the rat ileum was investigated. The volatile oil was obtained by steam distillation and fractionated using a silica gel column resulting in five fractions. Compounds of the fractions were identified by GC-MS. The influence of the volatile oil, its fractions and pure components on serotonin-induced [14C]guanidinium influx into N1E-115 cells was measured indicating the inhibitory interaction with the 5-HT3 receptor channel system. Most potent inhibitors of cation influx were the volatile oil, fraction 4, beta-pinene, terpinolene, alpha-copaene and alpha-phellandrene. The volatile oil and fractions 1 and 4 were not able to significantly influence either serotonin (10 microM)-induced maximum contraction of the rat ileum or the second phase of the biphasic contraction 2.5 min after serotonin addition. However, beta-pinene, terpinolene and alpha-phellandrene reduced both contractions. In conclusion, the volatile oil and distinct compounds such as terpinolene, beta-pinene and alpha-phellandrene interact with 5-HT3 receptor channel system and possess an antispasmodic effect at the rat ileum.


Subject(s)
Ileum/drug effects , Plant Oils/pharmacology , Serotonin 5-HT3 Receptor Antagonists , Serotonin Antagonists/pharmacology , Zingiber officinale , Animals , Cell Line, Tumor/drug effects , Cell Line, Tumor/metabolism , Dose-Response Relationship, Drug , Female , Ileum/metabolism , Mice , Neuroblastoma/pathology , Plant Oils/administration & dosage , Plant Oils/therapeutic use , Rats , Receptors, Serotonin, 5-HT3/metabolism , Rhizome , Serotonin Antagonists/administration & dosage , Serotonin Antagonists/therapeutic use
SELECTION OF CITATIONS
SEARCH DETAIL
...