ABSTRACT
OBJECTIVE: The aim: To evaluate the acceptance rate of COVID-19 vaccine among adolescents and exploring the association factors that affect the acceptability of the vaccine. PATIENTS AND METHODS: Materials and methods: The study is descriptive cross-sectional study based on online survey conducted on 541 adolescents in Iraqi middle Euphrates provinces. Survey data was collected from November 28, 2021 to April 20, 2022. RESULTS: Results: The study showed that about 53% (288 adolescents out of total 541) had not been vaccinated yet and approximately 55% of the not vaccinated adolescents refused to take the vaccine. The mean reasons of this hesitancy were falsified information, insufficient information, concerned about safety and effectiveness of the vaccine. The parents whether infected with COVID-19 or vaccinated considered as strong independent factors that will increase acceptance of vaccination among the adolescents while afraid from the vaccine was considerable independent factor that decrease the acceptance rate. CONCLUSION: Conclusions: High hesitancy rate toward COVID-19 vaccination among adolescents and their parents play significant role model in increasing the acceptability while concerning of the vaccine safety decreasing acceptability.
Subject(s)
COVID-19 Vaccines , COVID-19 , Adolescent , Humans , COVID-19 Vaccines/therapeutic use , Cross-Sectional Studies , Iraq , COVID-19/prevention & control , Fear , VaccinationABSTRACT
OBJECTIVE: The aim: The goal of this study was to asses if vitamin D3 protect rats against doxorubicin-induced cardiotoxicity. PATIENTS AND METHODS: Materials and methods: Overall twenty-one male rats were divided randomly into three groups (7 rats in each group). Control group in which rats received 0.9% normal saline for two weeks. Doxorubicin group (induced group): rats received 2.5mg/kg three times a week for two weeks and Vitamin D3 group (treated group): vitamin D3 was given in a dose 60000 IU/kg IP as single dose on the first day of the procedure. RESULTS: Results: Doxorubicin caused cardiotoxicity as indicated by a significant elevation (P < 0.01) in TNF-α, IL-6, MDA, cTnI and caspase-3 level, while TAC and Bcl-2 levels significantly (P < 0.01) reduced in cardiac tissues of rats in the doxorubicin group as compared with control group, also doxorubicin caused histological lesions. Vitamin D3 administration show cardioprotective effect reported by significant decrease (P >0.01) incTnI, Bcl2 and TAO as compared with DOX group, also show significant improvement (P >0.01) in cardiomyopathy histological lesions score. CONCLUSION: Conclusions: At their applied doses in the present study, vitamin D3 exerted a significant heart protective effect against cardiotoxicity induced by doxorubicin in rats probably by intrusive with Oxidative-stress, inflammatory response in addition to apoptotic pathway.
