ABSTRACT
The usefulness of five specific information-theoretical molecular descriptors was investigated for predicting the gas phase entropy of selected classes of acyclic and cyclic compounds. Among them, total information on atomic number (TIZ), graph vertex complexity (HV) and total information on bonds (TIBAT), considered together showed the best correlation along with a low standard deviation (r2 = 0.97, s = 21.14) with gas phase entropy values of 130 compounds. The multiple regression equation treating these three indices as independent variables was statistically highly significant which was evident from the F-statistics. In particular, very small difference between r2 and r2-pred values indicates that the regression model is not overfitted and is, therefore, suitable for prediction purposes. When truly used as a training set to predict (from regression equation) 40 additional compounds we get a very high correlation (r2 = 0.975), which remains almost identical (r2 = 0.97) for the combined data set of 170 compounds. The three indices appear to be useful descriptors producing correlation that remains stable with the change in the size of the data set. Also, the information-theoretical measures appear to capture an additive-cum-constitutive nature of gas phase entropy yielding an acceptable statistical fit.
Subject(s)
Entropy , Hydrocarbons/chemistry , Molecular Structure , Quantitative Structure-Activity Relationship , Regression AnalysisSubject(s)
Nephrostomy, Percutaneous/instrumentation , Peritoneal Diseases/therapy , Stents , Ureteral Diseases/therapy , Urinary Fistula/therapy , Adult , Female , Follow-Up Studies , Humans , Male , Middle Aged , Nephrostomy, Percutaneous/methods , Peritoneal Diseases/diagnostic imaging , Radiography , Retroperitoneal Space , Ureteral Diseases/diagnostic imaging , Urinary Fistula/diagnostic imagingABSTRACT
A retrospective analysis of 34 patients of obstructive renal failure, initially managed by percutaneous nephrostomy was performed. Pre procedure blood biochemical profile was compared with upto one week follow-up of blood chemistry. There was a decline of 71.1% and 56.08% (P-values 0.0001 and 0.0028) in the mean values of serum creatinine and blood urea nitrogen respectively at 7 days after the procedure. Improvement in blood biochemical profile was solely dependent on performance of percutaneous nephrostomy.
Subject(s)
Kidney Failure, Chronic/surgery , Nephrostomy, Percutaneous , Ureteral Obstruction/surgery , Adolescent , Adult , Aged , Blood Urea Nitrogen , Child , Child, Preschool , Creatinine/blood , Female , Humans , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/etiology , Male , Middle Aged , Retrospective Studies , Ureteral Obstruction/complicationsABSTRACT
Amoebic liver abscess (ALA) is a common extra-intestinal presentation of amoebiasis caused by Entamoeba histolytica. The liver abscess may be complicated by rupture into adjacent structures. Common organs involved include thorax, peritoneum and pericardium. Rupture into the gastrointestinal tract is extremely rare. We report a patient who developed a hepatoduodenal fistula complicating an amoebic liver abscess. Suspicions were raised on finding air in the liver abscess on ultrasound scanning. Diagnosis was confirmed on a water-soluble (Gastrografin) swallow (Fig. 1 a,b). Complications of ALA are associated with a high morbidity and mortality and early diagnosis is important. To our knowledge only one previous case of a hepatoduodenal fistula complicating an ALA with radiological confirmation has been reported.
