[A "plethora", minor and transient, as an immediate cause of a cerebrovascular accident]. / Una "pletora", minima e fugace, come concausa immediata degli episodi di accidenti vascolari cerebrali.

Even if the well-known predisposing factors play an essential role in the realization of cerebrovascular accidents, in these last years the possible importance of the hemoreologic parameters is still a topic under discussion. The authors found a significant increase of the considered hemoreologic parameters (HT, Hb, RBC) in the patients hospitalized for cerebrovascular accidents compared to controls, without differences for gender, even if this increase remained into the limits of normal range. Conversely, no significant differences were found concerning the considered metabolic parameters.

Acute sublingual nifedipine and adrenergic activation: a chronobiologic attempt of optimized administration in healthy subjects.

Nifedipine has been shown to increase heart rate and plasma catecholamines, due to an adrenergic activation. Two healthy male subjects, after a period of sinchronization, have self-measured heart rate (HR) every 30 min for two consecutive days through a portable, non invasive, automatic device. The data were then analysed by means of chronobiologic procedures, to verify their personal HR acrophase. Forty-eight hours later, the same subjects repeated the trial, assuming 20 mg of sublingual nifedipine just one hour before their calculated HR acrophase, and data were analysed at the same way. After drug assumption, both HR acrophases and mesors failed to show any modification.