ABSTRACT
We investigated the prevalence of 5HT2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation. A total of 350 participants were enrolled in a prospective study. Two hundred and forty-five cases with lifelong premature ejaculation joined this study, in addition to 105 controls. We instructed the partners of the cases to measure the IELT of the first intercourse only using a stopwatch for 1 month. Genotyping was carried out at the end of the study. The results showed that the majority of the patients and controls were Cys/Cys. A highly significant statistical association was found between the studied gene polymorphisms and IELT among cases (p-values = .009). The study emphasised the potential role of 5HT2C receptor gene polymorphisms in patients with lifelong premature ejaculation.
Subject(s)
Polymorphism, Genetic , Premature Ejaculation/genetics , Receptor, Serotonin, 5-HT2C/genetics , Adult , Case-Control Studies , Egypt , Genotyping Techniques , Humans , Male , Prospective Studies , Time Factors , Young AdultABSTRACT
Alloplastic spermatocele implants were used for 11 infertile men with bilateral congenital absent vas. Successful recovery of spermatozoa from the prosthesis was obtained in 8 cases for periods up to 4 months after the operation. Single aspirations showed 200,000 to 30 million spermatozoa, and the aspirated volume varied between 0.4 and 1.0 ml. Artificial insemination of the wife was done at the time of ovulation, but no pregnancy has been achieved yet. In only 3 cases the aspirated fluid did not show spermatozoa, which might be due to occlusion of the vasa efferentia or ductus epididymis.
