Examination of Crash Injury Risk as a Function of Occupant Demographics.

The objectives of this study were to provide insights on how injury risk is influenced by occupant demographics such as sex, age, and size; and to quantify differences within the context of commonly-occurring real-world crashes. The analyses were confined to either single-event collisions or collisions that were judged to be well-defined based on the absence of any significant secondary impacts. These analyses, including both logistic regression and descriptive statistics, were conducted using the Crash Investigation Sampling System for calendar years 2017 to 2021. In the case of occupant sex, the findings agree with those of many recent investigations that have attempted to quantify the circumstances in which females show elevated rates of injury relative to their male counterparts given the same level bodily insult. This study, like others, provides evidence of certain female-specific injuries. The most problematic of these are AIS 2+ and AIS 3+ upper-extremity and lower-extremity injuries. These are among the most frequently observed injuries for females, and their incidence is consistently greater than for males. Overall, the odds of females sustaining MAIS 3+ (or fatality) are 4.5% higher than the odds for males, while the odds of females sustaining MAIS 2+ (or fatality) are 33.9% higher than those for males. The analyses highlight the need to carefully control for both the vehicle occupied, and the other involved vehicle, when calculating risk ratios by occupant sex. Female driver preferences in terms of vehicle class/size differ significantly from those of males, with females favoring smaller, lighter vehicles.

Effects of 24 hours of tobacco withdrawal and subsequent tobacco smoking among low and high sensation seekers.

INTRODUCTION: Previous studies have indicated that high sensation seekers are more sensitive to the reinforcing effects of nicotine, initiate smoking at an earlier age, and smoke greater amounts of cigarettes. This study examined the influence of sensation-seeking status on tobacco smoking following deprivation in regular tobacco users. METHODS: Twenty healthy tobacco-smoking volunteers with low or high impulsive sensation-seeking subscale scores completed 2 consecutive test days per week for 3 consecutive weeks. Each week, a range of self-report, performance, and cardiovascular assessments were completed during ad libitum smoking on Day 1 and before and after the paced smoking of a tobacco cigarette containing 0.05, 0.6, or 0.9 mg of nicotine following 24 hr of tobacco deprivation on Day 2. In addition, self-administration behavior was analyzed during a 2-hr free access period after the initial tobacco administration. RESULTS: In high sensation seekers, tobacco smoking independent of nicotine yield ameliorated deprivation effects, whereas amelioration of deprivation effects was dependent on nicotine yield among low sensation seekers. However, this effect was limited to a small subset of measures. Subsequent cigarette self-administration increased in a nicotine-dependent manner for high sensation seekers only. CONCLUSIONS: Compared with low sensation seekers, high sensation seekers were more sensitive to the withdrawal relieving effects of nonnicotine components of smoking following 24 hr of deprivation on selective measures and more sensitive to nicotine yield during subsequent tobacco self-administration. These results are consistent with studies suggesting that factors driving tobacco dependence may vary as a function of sensation-seeking status.

Individual differences in drug abuse vulnerability: d-amphetamine and sensation-seeking status.

RATIONALE: While the personality dimensions of novelty seeking and sensation seeking are associated with drug abuse vulnerability, the mechanisms associated with this vulnerability remain obscure. OBJECTIVE: This study examined the behavioral effects of d-amphetamine in healthy volunteers scoring in the upper and lower quartiles based on age- and gender-adjusted population norms on the impulsive Sensation-Seeking Scale (SSS) of the Zuckerman-Kuhlman personality questionnaire (ZKPQ). METHOD: Participants completed 7-day outpatient studies examining the subjective, performance, and cardiovascular effects of d-amphetamine (0, 7.5, and 15 mg/70 kg, p.o.) under double-blind conditions according to a randomized block design. Performance tasks included behavioral measures of impulsivity, including attention, inhibition, and risk-taking behavior. RESULTS: No differences in baseline performance or d-amphetamine effects on measures of attention, inhibition, and risk-taking behavior were observed. High impulsive sensation seekers reported greater increases on several subjective report measures associated with drug abuse potential, including visual analog scales feel drug, like drug, and high. CONCLUSIONS: Healthy adults scoring in the top quartile on the population of the impulsive SSS of the ZKPQ may be vulnerable to the abuse potential of d-amphetamine.

Trends in mortality from diabetes mellitus in Canada, 1986-2000.

The purpose of this study was to examine trends in diabetes mellitus (DM) mortality rates in Canada, including analysis at the provincial level, during the period 1986-2000. The study population included Canadians aged 35 and over. Age-standardized mortality rates (ASMRs) were computed. Linear regression was used to calculate the average annual percentage change (AAPC) by age, sex and province. The results showed a substantial increase in DM mortality rates among those aged 35 and over, particularly for men; the AAPC indicated an increase of 2.4% for men and 0.7% for women. When the mortality rates were plotted for three time periods, the rates increased with each successive age group and period for both sexes. Mortality from DM increased significantly in both sexes in Canada between 1986 and 2000, particularly in men.

Characteristics and risk factors for accident injury in Canada from 1986 to 1996: an analysis of the Canadian Accident Injury Reporting and Evaluation (CAIRE) database.

This study analyzed the database of Canadian Accident Injury Reporting and Evaluation (CAIRE) for the injuries reported from January 1986 to March 1996 in seven provinces at children's or general hospitals in Canada. In order to describe the characteristics of injuries, we compared the different categories of injuries by sex and by age groups, identified patterns of injuries, and detected the products causing injury to Canadian people. The results showed that there were 130,489 injury cases in Canada during the 10 years from 1986 to 1996. The 10-19 year age group had 57,582 cases, representing 44.13% of total injuries, and making it the group with the highest occurrence of injuries. The male injury rate (69.75%) was significantly higher than the female rate (30.25%) (P = 0.0001). Six areas were identified as priorities for intervention: 1) injuries occurring on playgrounds among children and youth; 2) sports and playground apparatus injuries and injuries sustained in transit among young people; 3) the top five causes of injuries; 4) diagnosis and treatment of injuries; 5) consumer products and safety; and 6) nature and physical sites of injuries. Further work is needed in: evaluating injury causes, comparing the results with reports from other countries and the necessary approaches and prevention measures to reduce and control injury occurrences to improve the quality of consumer products, and to protect the health of the population in Canada.