1.
J Antibiot (Tokyo)
; 48(11): 1240-7, 1995 Nov.
Article
in English
| MEDLINE
| ID: mdl-8557563
ABSTRACT
Bacillomycin Lc, a new antifungal antibiotic of the iturin class, was isolated from a strain of Bacillus subtilis as a set of five congeners. The structure as determined by chemical and spectrometric analyses has been shown to differ from that of bacillomycin L by sequence changes from aspartate-1 to asparagine-1 and from glutamine-5 to glutamate-5. The five congeners differ from each other only in the structure of the aliphatic side chain of the constituent beta-amino acid. The hydrophobicity of the beta-amino acid affects the antifungal activity of the congener, as activity increased in the order of increased congener retention on a reversed-phase HPLC column.
Subject(s)
Antifungal Agents/isolation & purification , Bacillus subtilis/metabolism , Amino Acid Sequence , Amino Acids/analysis , Amino Acids/chemistry , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Chemical Phenomena , Chemistry, Physical , Chromatography, High Pressure Liquid , Fungi/drug effects , Magnetic Resonance Spectroscopy , Molecular Sequence Data , Molecular Structure , Peptides, Cyclic/chemistry , Peptides, Cyclic/isolation & purification , Peptides, Cyclic/pharmacology , Sequence Analysis , Spectrometry, Mass, Fast Atom Bombardment
2.
J Econ Entomol
; 64(3): 621-4, 1971 Jun.
Article
in English
| MEDLINE
| ID: mdl-5558272