ABSTRACT
The case histories of two Afro-Trinidadian brothers aged 8 and 11 years who developed end-stage renal disease (ESRD) are presented. Neither had had cause in the past to seek medical attention for any renal-related illness. At presentation both had anaemia, growth failure and other clinical and laboratory evidence of ESRD. Kidney histology in one child was consistent with familial juvenile nephronophthisis (NPH). This is common cause of ESRD in children in other countries but it has not been recognized previously in Trinidadian and other West Indian children, and should be considered as a possible aetiology in West Indian children presenting with renal failure.(AU)
Subject(s)
Child , Humans , Male , Case Reports , Renal Insufficiency, Chronic/pathology , Medullary Sponge Kidney/complications , Medullary Sponge Kidney/genetics , Medullary Sponge Kidney/pathology , Nuclear Family , Peritonitis/etiology , Trinidad and Tobago , Growth Disorders/etiology , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/geneticsABSTRACT
An extensive study of 3 isolated communities (1,700 persons) in Puerto Rico was presented (AU)
