Seasonal Population Dynamics of Megacopta cribraria (Hemiptera: Plataspidae) in Kudzu and Soybean, and Implication for Insecticidal Management in Soybean.

Megacopta cribraria (F.), an invasive species introduced from Asia in 2009, is now prolific in the southeastern United States. Megacopta cribraria develops primarily on kudzu and soybean completing two generations. It is not well understood how this economic pest is affected by changes in geographic distribution in the United States or how population levels have changed since its establishment. The effect of insecticide application timing on field populations of M. cribraria is not well documented. These studies seek to understand how population dynamics of M. cribraria vary with geographic regions in Georgia. Effect of application timing on populations throughout the growing season was also examined. Weekly from 2012 to 2013, all life stages were enumerated from kudzu and soybean environments at several locations throughout Georgia from sweeps samples and flight intercept captures. Coordinates were recorded for locations, and classified as belonging to the Piedmont or Coastal Plain region of the state. Single spray trials were conducted from 2011-2014, and applications were made to soybean at intervals throughout the season. From 2012 to 2015, two kudzu patches near Griffin, GA, were monitored to detect population changes. Differences in population dynamics from locations around the state were found, but no clear effect of latitude, longitude, or region was observed. Insecticide applications applied in July suppressed nymph populations significantly better than treatments made earlier or later. Megacopta cribraria populations declined in 2014 and 2015 compared with 2012 and 2013. These studies provide the critical information for M. cribraria management in soybean in the southeastern United States.

Effect of Planting Date and Maturity Group on Soybean Yield Response to Injury by Megacopta cribraria (Hemiptera: Plataspidae).

The kudzu bug, Megacopta cribraria (F.), is an invasive member of the family Plataspidae originating from Asia. Since its discovery in Georgia in 2009, its distribution has increased to 13 southern and eastern states. In the United States, M. cribraria is bivoltine and has two primary developmental hosts, kudzu and soybean. Here, we evaluated the yield response of soybean to M. cribraria feeding injury in relation to planting date and soybean maturity group. The study contained four replicated trials in Griffin, Tifton, and Midville, GA, in 2012 and 2013. Four planting dates from April to July, served as the whole plot of a split-plot design with maturity group five and seven soybean and insecticide (lambda-cyhalothrin) randomized within planting date. Egg masses, nymphs, and adults were enumerated weekly to biweekly until soybean reached maturity. Two generations were observed in April and May plantings, but only one generation was evident in June and July soybean plantings. Insecticide-protected plots had consistently higher yields than unprotected plots. Grain yield was greatest in the May planting and lowest in the July planting. Season-long feeding by M. cribraria reduced grain yield in April, May, and June plantings but not in the July planting. Maturity group and planting date had significant effects on yield components in most comparisons. This study indicated that early-planted soybean are at greater risk of yield loss from M. cribraria injury compared with later-planted soybean.

Public attitudes toward mental illness in Africa and North America.

OBJECTIVE: Public attitudes toward mental illness in two widely disparate cultures, Canada and Cameroon, were compared using an experimental version of a survey instrument, the Public Opinion Survey of Human Attributes-Mental Illness or POSHA-MI(e). METHOD: 120 respondents rated POSHA-MI(e) items relating to mental illness on 1-9 equal appearing interval scales: 30 in English and 30 in French in both Cameroon and Canada. Additionally, 30 matched, monolingual English, American respondents were included as a comparison group. RESULT: In Canada (and in the USA), attitudes were generally more positive and less socially stigmatizing toward mental illness than in Cameroon. Differences between countries were much larger than differences between language groups. CONCLUSION: Consistent with other research, beliefs and reactions of the public regarding mental illness reflect stigma, especially in Cameroon. Cultural influences on these public attitudes are more likely important than language influences. Results of this field test of the POSHA-MI(e), documenting differences in public attitudes toward mental illness in two divergent cultures, support its further development.

Precision application of aldicarb to enhance efficiency of thrips (Thysanoptera: Thripidae) management in cotton.

Field studies were conducted during 1999-2001 in two climatic/edaphic areas of Georgia (Southern Piedmont and East Gulf Coastal Plain) to test the hypothesis that precision placement of aldicarb with cotton seed in hill planting at spatially specific intervals could decrease insecticide use for management of tobacco thrips, Frankliniella fusca (Hinds). Precision-placed aldicarb controlled thrips during cotton seedling stages using per ha amounts of one-half or less than standard in-furrow application rates with no significant differences in yield. Residual analysis of cotton plants showed that plants in precision placement plots had as much or more aldicarb and aldicarb metabolites present as compared with cotton treated with conventional in-furrow treatments. Higher rates of precision-placed aldicarb did cause phytotoxic burning early in the growing season, but no significant impact on yield was observed.

Ranitidine bismuth citrate with clarithromycin alone or with metronidazole for the eradication of Helicobacter pylori.

BACKGROUND: Both triple therapy with ranitidine bismuth citrate (RBC) plus two antibiotics for 7 days and dual therapy of RBC with clarithromycin for 14 days have been extensively studied; both regimens effectively eradicate Helicobacter pylori. However, few studies have assessed the efficacy of dual therapy given for 7 days. AIM: To compare the efficacy and safety of RBC 400 mg with clarithromycin 500 mg, alone or with metronidazole 400 mg, given twice daily for 7 days for the eradication of H. pylori. METHODS: This single centre, randomized, double-blind study involved 118 patients with dyspepsia or a history of peptic ulcer disease. H. pylori infection was detected initially by CLO test, and confirmed in 109 patients by urea breath test and/or microbiology culture. H. pylori eradication was assessed 4 and 12 weeks after the end of treatment by urea breath test. H. pylori antibiotic susceptibility was assessed pre-study in all patients, and post-treatment in patients with a positive post-treatment urea breath test. Adverse events were recorded throughout the study. RESULTS: H. pylori was eradicated in 93% of patients who received RBC with clarithromycin and metronidazole and in 84% of patients who received RBC with clarithromycin (intention-to-treat rates). Per protocol eradication rates were 98% and 90% for triple therapy and dual therapy, respectively. The eradication of metronidazole-resistant H. pylori was achieved in 100% and 88% of patients following dual therapy and triple therapy, respectively, and acquired resistance to clarithromycin occurred in only one patient following treatment failure. Both treatments were well-tolerated; only one patient (2%) was withdrawn from each treatment group due to adverse events. CONCLUSIONS: RBC with clarithromycin and metronidazole is a highly effective and well-tolerated triple therapy regimen for the eradication of H. pylori. RBC with clarithromycin dual therapy has a similar efficacy, and offers an alternative to triple therapy when there are concerns about treatment with metronidazole or the use of multiple antibiotics. Both regimens are effective against antibiotic-resistant strains of H. pylori.

Nuclear localization of the Saccharomyces cerevisiae HMG protein NHP6A occurs by a Ran-independent nonclassical pathway.

The Saccharomyces cerevisiae non-histone protein 6-A (NHP6A) is a member of the high-mobility group 1/2 protein family that bind and bend DNA of mixed sequence. NHP6A has only one high-mobility group 1/2 DNA binding domain and also requires a 16-amino-acid basic tail at its N-terminus for DNA binding. We show in this report that nuclear accumulation of NHP6A is strictly correlated with its DNA binding properties since only nonhistone protein 6 A-green fluorescent protein chimeras that were competent for DNA binding were localized to the nucleus. Despite the requirement for basic residues within the N-terminal segment for DNA binding and nuclear accumulation, this region does not appear to contain a nuclear localization signal. Moreover, NHP6A does not bind to the yeast nuclear localization signal receptor SRP1 and nuclear targeting of NHP6A does not require the function of the 14 different importins. Unlike histone H2B1 which contains a classical nuclear localization signal, entry of NHP6A into the nucleus was found to be independent of Ran as judged by coexpression of Ran GTPase mutants and was shown to occur at 0 degrees C after a 15-min induction. These unusual properties lead us to suggest that NHP6A entry into the nucleus proceeds by a nonclassical Ran-independent pathway.

The effects of left- versus right-hemisphere lesions on the sensitivity to intra- and interconceptual semantic relationships.

Studies on split-brain, normal and brain-damaged subjects suggest differences in the processing of semantic relationships by the two hemispheres. Various authors have conceived of this distinction in terms of the paradigmatic/syntagmatic dissociation, and the connotative and denotative meanings of words, and as reflecting different types of links between words. Drews has suggested that a left-hemisphere lesion would affect the processing of intraconceptual relationships, while a right-hemisphere lesion would impair the processing of interconceptual relationships. The goal of this study was to test this hypothesis, using a number of intra- and interconceptual semantic relationships. Pairs of common words were submitted to left-hemisphere brain-damaged and right-hemisphere brain-damaged subjects. The task required subjects to indicate whether or not there was any relationship between the words. The results only partially support the hypothesis. The right/left opposition applied to only one of three types of intraconceptual relationships (whole-part relation) and to one of two types of interconceptual relationship (same location relation). This partially unexpected result is discussed in reference to other studies.

Comparison of ranitidine bismuth citrate plus clarithromycin with omeprazole plus clarithromycin for the eradication of Helicobacter pylori.

BACKGROUND: Many dual and triple therapy treatment regimens have been proposed for the eradication of Helicobacter pylori. However, assessing the relative efficacy of these regimens is complicated by differences in study design, and few well-controlled comparative studies have been reported. METHODS: This multicentre, randomized, double-blind study involved 530 duodenal ulcer patients, of whom 520 had confirmed H. pylori infection. Patients received 14 days b.d. dual therapy of either ranitidine bismuth citrate (RBC) 400 mg or omeprazole 20 mg, both with clarithromycin 500 mg to eradicate H. pylori, followed by a further 14 days of treatment with RBC 400 mg b. d. or omeprazole 20 mg o.d. to facilitate ulcer healing. H. pylori eradication and ulcer healing were assessed at least 26 days after the end of treatment. Adverse events were recorded throughout the study. RESULTS: H. pylori was eradicated in 90% of patients who received RBC with clarithromycin and in 66% of patients who received omeprazole with clarithromycin (per protocol; P<0.001). intention-to-treat eradication rates were 77% and 60%, respectively (P<0.001). Ulcer healing rates were 97% in the RBC treatment group and 95% in the omeprazole treatment group. Only 3% and 1% of patients in the RBC and omeprazole treatment groups, respectively, were withdrawn due to adverse events. CONCLUSIONS: RBC with clarithromycin is a simple and highly effective dual therapy regimen for the eradication of H. pylori, and is significantly more effective than omeprazole with clarithromycin. Both treatment regimens are well tolerated and effectively heal duodenal ulcers.

Picture naming of cognate and non-cognate nouns in bilingual aphasia.

Previous research has found differences in the speed and accuracy of responses involving concrete cognate nouns and non-cognate nouns in a range of written and "on-line" tasks using neurologically unimpaired, bilingual adults. The present study investigated whether cognateness affects verbal confrontation naming performance in balanced French/English bilinguals (N = 15 aphasic and 15 non-aphasic subjects). Subjects met selection criteria for equal proficiency, regular use, and early acquisition of both languages. Results of a picture naming test show that cognate pictures were more often correctly named in both languages than were non-cognates. Some error types and self-correction behaviors also varied with cognate status. There were similarities between the results of this study and those of previous studies of monolingual naming. Some error types and self-correction strategies appear to be unique to bilingual speakers. Theoretical questions and treatment applications arising from these findings are outlined.

Measles, mumps and rubella vaccine: current safety issues.

The current state of knowledge regarding the safety of measles, mumps and rubella vaccine (MMR) is reviewed. Although there are known adverse reactions to the vaccine, the majority are relatively minor and have no long term consequences, and those that do have long term consequences are extremely rare. Contraindications, known adverse reactions that may follow MMR immunisation, publicised adverse events for which a causal association with MMR has not been established, and the complications that may follow an infection with wild-type measles, mumps or rubella, are discussed. The article also discusses, with examples, the misleading information that can be obtained on the internet and in the public press. It is vital that the general public have an understanding of the great benefits and low risks associated with the use of MMR vaccine, because it is important that they consent to the administration of MMR vaccine to their children in order to ensure the success of universal immunisation programmes and the control of measles, mumps and rubella. Therefore, it becomes increasingly important for health professionals to use innovative education methods to promote immunisation and counteract the incorrect and misleading information that is readily available on the internet and in the media.

Bilingual aphasia: semantic organization, strategy use, and productivity in semantic verbal fluency.

A semantic verbal fluency task (Animals, Foods) was administered to 16 aphasic, bilingual adults in French and English. Each subject was tested twice in each language. The two goals of the study were to compare performance across languages and to determine the effect of a deliberate grouping strategy on productivity. All subjects claimed approximately equal prestroke abilities in both languages. The number of words subjects produced was not significantly different in the two languages. Semantic organization across languages was also similar on Test 1. On Test 2, 8 subjects were instructed to group items by subcategory and 8 simply repeated the task. There was no consistent between-group difference in number of correct words or in the semantic organization of responses. Implications for the clinical use of verbal fluency tests and for further research into bilingual lexicosemantic systems are discussed.

Ranitidine bismuth citrate with clarithromycin given twice daily effectively eradicates Helicobacter pylori and heals duodenal ulcers.

OBJECTIVE: Ranitidine bismuth citrate (RBC) b.i.d. with clarithromycin q.i.d. eradicates Helicobacter pylori (H. pylori) in 82-94% of patients, and heals duodenal ulcers in 88-90% of patients. This double blind, placebo-controlled study examines the efficacy of a simpler b.i.d. treatment regimen, and examines the potential benefit of including a second antibiotic, metronidazole, to the b.i.d. treatment regimen. METHODS: A total of 648 patients with active duodenal ulcer received RBC 400 mg b.i.d. for 4 wk, coprescribed with clarithromycin 250 mg q.i.d., clarithromycin 500 mg b.i.d., or clarithromycin 500 mg b.i.d. with metronidazole 400 mg b.i.d. for the first 2 wk of treatment. Endoscopies were performed prestudy, after 4 wk of treatment, and at least 4 wk posttreatment. H. pylori status was assessed by CLOtest, 13C-urea breath test (UBT), and histology prestudy, and by UBT and histology at least 4 wk posttreatment. Adverse events were recorded at each visit. RESULTS: All three regimens were highly effective and well tolerated. H. pylori eradication rates were 84-94% and duodenal ulcer healing rates were 92-96% (observed data). Highest H. pylori eradication and ulcer healing rates were achieved with RBC 400 mg b.i.d. with clarithromycin 500 mg b.i.d. CONCLUSION: Ranitidine bismuth citrate with clarithromycin 500 mg b.i.d. provides an effective, simple and well tolerated regimen for the eradication of H. pylori and healing of duodenal ulcers.

Nurse education in competitive markets: the case for relationship marketing.

Since the National Health Service reforms of the late 1980s, nurse education has been increasingly subject to market forces. This new competitive environment presents not only threat, but also challenge and opportunity. Providers of nurse education who recognize the need for market orientation and develop responsive marketing strategies will maximize their potential for market retention and growth. Traditional marketing strategies have considerable limitations for public sector services. The new and growing field of relationship marketing offers nurse education an opportunity to retain and develop profitable relationships with both internal and external markets. This paper reviews the marketing arena in nurse education and proposes context-based qualitative research to ascertain definitive constructs of service quality. Such constructs might then be rooted in a theoretical framework of service quality measurement, and be measured within the disconfirmation paradigm of relationship marketing.

The role of library and information services in the modular curriculum.

Radical changes in nurse education, accompanied by advances in library and information services (LIS), set against a background of ever-expanding nursing literature and information, have favoured the development of good practices in curriculum development and student-centred learning. This paper discusses the experience at Keele University of enhanced collaborative effort between curriculum planners and LIS staff, and aims to show how LIS can facilitate student learning and contribute to curriculum planning and delivery, quality resource provision, evaluation processes and life-long learning.

In vivo nuclear transport kinetics in Saccharomyces cerevisiae.

We have described a direct fluorescence assay to measure the relative rates of NLS-directed import and passive export of an NLS-GFP fusion protein in yeast. The design and construction of the reporter GFP fusion, its spectral qualities, size, use of inducible promoters, and the choice of NLS, are variables that could extend the method's utility. Future applications will almost certainly demand the quantification of transport rates in single cells using image analysis techniques. As is the case whenever cellular processes are studied in vivo, the in vivo nuclear trafficking properties of NLS-GFP are complicated and poorly understood. Some will be attracted to NLS-GFP kinetic assays simply because so little is known about the function and regulation of the transport apparatus in living cells. At the same time, the uncertainties that accompany in vivo work necessarily prevent the rigorous interpretation of data, which biochemists expect from experiments performed in vitro using highly purified enzymes.

Semantic organization, strategy use, and productivity in bilingual semantic verbal fluency.

This study of semantic verbal fluency addressed two research questions: (1) What are the between-language similarities and differences in the performance of balanced bilinguals? (2) What is the relationship between productivity and the use of a semantic grouping strategy to organize responses? Forty neurologically normal, bilingual adults were tested twice in each language (French/English), in a 2 (Language) by 2 (Test) by 2 (Group) design. On Test 2, half the 40 subjects were instructed to group items by subcategory, while half simply repeated the test. Results showed (1) many more between-language similarities than differences and (2) no between-group differences in productivity.

Tournament water skiing trauma.

Tournament water skiing is an increasingly popular and internationally successful sport in Great Britain, despite the climate. The kinematics and injury patterns of the three disciplines will be unfamiliar to most clinicians and are described, with estimation of the stresses. Advances in equipment over the last 15 years have reduced the risk of severe injury in the tricks event, while high speed impacts are responsible for the majority of trauma in slalom and jump. There is a surprisingly high incidence of injury to the lumbar spine during the high impact jump event. Comparison with findings in other sports suggests that the spine may be damaged by overuse, particularly before skeletal maturity.

Unmarried motherhood: childhood experiences described by 22 adults whose mother was unmarried when they were born.

Content analysis was used to examine the childhood experiences of 22 autobiographers whose mother was unmarried when they were born. Their childhoods varied considerably. For significant periods of time, 12 lived with their mother alone or with her and their own father or a stepfather, 5 lived with their mother and her parents, 2 lived with unmarried aunts, and 7 lived in foster homes. Three mothers died, one was institutionalized and one abandoned her child without making alternative arrangements. Seven autobiographers were never told the identity of their father, and another 5 had to wait many years before they were told. This created an unhappiness in these individuals when they were teenagers that only increased with age. These findings cannot be assumed to apply to unmarried mothers and their children today; however, they raise some important issues for health care professionals and highlight the need for more research on contemporary unmarried motherhood.

Unmarried motherhood.

In the past, the children of unmarried women were stigmatized and treated as second-class citizens by both society and the law. As societal attitudes have become more tolerant, however, the laws have been changed to ensure equality for all children. Despite this, there is little evidence to show that the children of unmarried mothers receive the rights guaranteed them by law, or that the birth parents and caregivers are even aware of those rights.

Extracorporeal membrane oxygenation and indications for cardiopulmonary bypass in the neonate.

Extracorporeal membrane oxygenation (ECMO) is a rescue technique used for term and near-term neonates who have respiratory failure that is unresponsive to conventional therapy. The complexity of the equipment necessitates intensive training of a specialized team before setting up an ECMO unit. An understanding of the physiology underlying ECMO and the criteria used for patient selection assists the nurse in identifying neonates who might benefit from the technique.