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Am J Cardiol ; 107(4): 516-21, 2011 Feb 15.
Article in English | MEDLINE | ID: mdl-21184991

ABSTRACT

A paucity of data on outcome of coronary multislice computed tomography (CT) is available. The aim of this study was to assess the long-term follow-up of 64-slice CT in a homogenous patient group. In total 222 patients (136 men, 61%, 59 ± 11 years of age) with chest pain at intermediate risk of coronary artery disease (CAD) and no previous CAD underwent 64-slice CT. Coronary lesions were considered significant or not based on a threshold of 50% luminal narrowing. Plaques were classified as calcified, noncalcified, and mixed based on type. End point during follow-up was major adverse cardiac events (nonfatal myocardial infarction, unstable angina requiring hospitalization, myocardial revascularization). Coronary plaques were detected in 162 patients (73%). Coronary artery stenosis was significant in 62 patients. Normal arteries were found in 59 patients (27%). During a mean follow-up of 5 ± 0.5 years, 30 cardiac events occurred. Annualized event rates were 0% in patients with normal coronary arteries, 1.2% in patients with nonsignificant stenosis, and 4.2% in patients with significant stenosis (p <0.01). Predictors of cardiac events were presence of significant stenosis, proximal stenosis, and multivessel disease. Noncalcified and mixed plaques had the worse prognosis (p <0.05). In conclusion, 64-CT provides long-term incremental value in patients at intermediate risk of CAD.


Subject(s)
Chest Pain/diagnostic imaging , Coronary Angiography , Coronary Artery Disease/diagnostic imaging , Tomography, X-Ray Computed , Aged , Angina, Unstable/diagnostic imaging , Coronary Angiography/methods , Coronary Artery Disease/pathology , Coronary Stenosis/diagnostic imaging , Female , Follow-Up Studies , Humans , Male , Middle Aged , Myocardial Revascularization , Predictive Value of Tests , Prognosis , Retrospective Studies , Risk Assessment , Risk Factors , Sensitivity and Specificity , Surveys and Questionnaires
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