ABSTRACT
We report an infant who, after prolonged intravenous propofol infusion for treatment of status epilepticus, developed dramatic cardiac conduction disturbances and tachyarrhythmias in the setting of only mild metabolic acidosis and good ventricular function. Certain electrocardiographic findings were similar to those observed in the Brugada syndrome as well as in adult patients with propofol toxicity who suffered fatal ventricular arrhythmias. This case illustrates that serious arrhythmias can occur during prolonged high-dose propofol infusion in young patients, probably through a direct electrophysiologic membrane effect.
Subject(s)
Brugada Syndrome/chemically induced , Brugada Syndrome/diagnosis , Propofol/administration & dosage , Propofol/adverse effects , Tachycardia, Ventricular/chemically induced , Tachycardia, Ventricular/diagnosis , Anesthetics, Intravenous/administration & dosage , Anesthetics, Intravenous/adverse effects , Diagnosis, Differential , Humans , Infant , Infusions, Intravenous/adverse effects , MaleABSTRACT
This study examined the incidence of cardiac conduction abnormalities and ventricular arrhythmias after the transcatheter closure of muscular ventricular septal defects (MVSDs) using the Amplatzer device occluder. From the records of 27 patients who underwent 33 consecutive MVSD device closures, a low incidence of permanent and transient cardiac conduction disturbances was observed. Heart rate variability was less after the closure of multiple MVSDs compared with single MVSDs.
