ABSTRACT
The aim of this study was to demonstrate that the addition of a bioadhesive polymer to econazole, which increases the duration of the active drug at the site of infection, leads to a greater frequency of negative culture after treatment and probably reduces the recurrence rate of vaginal candidiasis.180 women with vaginal candidiasis were treated with 150 mg vaginal ovules econazole nitrate with (group A) or without (group B) polycarbophil. After 3 days of treatment the negative culture of Candida albicans reached 98.6% in group A and 84.8% in B group, while the overall persistence (C. albicans, C. glabrata, C. krusei, and C. parapsilosis) was 5.6% and 30%, respectively. During a 60-day follow-up, only one case out of 85 (1.2%) in group A reported recurrence while in group B there were 6 out of 63 (9.5%) recurrences. We conclude that, since the women were treated with the same amount of econazole, the better clinical and microbiological results can be attributed to polycarbophil, as confirmed by a significant reduction of recurrences.
Subject(s)
Acrylic Resins/administration & dosage , Antifungal Agents/administration & dosage , Candida albicans/drug effects , Candidiasis, Vulvovaginal/drug therapy , Drug Carriers/administration & dosage , Econazole/administration & dosage , Adolescent , Adult , Candida albicans/isolation & purification , Female , Humans , Middle AgedABSTRACT
We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.
Subject(s)
Drug Resistance, Bacterial/genetics , Mycoplasma hominis/genetics , RNA, Ribosomal, 23S/genetics , Anti-Bacterial Agents/pharmacology , Base Sequence , DNA, Bacterial/analysis , Macrolides , Molecular Sequence Data , Mycoplasma hominis/drug effects , Phenotype , Point Mutation , Sequence Homology, Nucleic AcidABSTRACT
The levels of flurithromycin in gynecological tissue in 20 female patients were studied after preoperative administration. The tissue flurithromycin levels obtained were comparable to those obtained in serum at 3 and 4 h but were frequently higher than those in serum at 6 and 12 h. Flurithromycin reached the highest concentrations in ovary at 4 h and in endometrium at 6 h.
