ABSTRACT
Large longitudinal relaxivities were observed in Mn(II)-containing Prussian blue analogue nanoparticles. At low concentrations and high field (7 T), a remarkable positive contrast enhancement was seen which exceeded that of clinical contrast agents and was attributed to the very large proportion of surface atoms of these coordination nanoparticles.
Subject(s)
Antineoplastic Agents/chemistry , Contrast Media/chemical synthesis , Magnetic Resonance Imaging/methods , Manganese Compounds/chemistry , Nanoparticles/chemistry , Antineoplastic Agents/pharmacology , Drug Screening Assays, Antitumor , Ferrocyanides/chemistry , HEK293 Cells , Humans , Manganese Compounds/pharmacology , Quantum DotsABSTRACT
This article discusses the screening of chemical reactions using a microreactor equipped with infrared spectroscopy as online analytics. An esterification reaction has been optimized in continuous mode with the proposed setup. The esterification did not work well due to the material of the microreactor (stainless-steel 316Ti) that catalyzed the decomposition of formic acid. However, despite the occurrence of decomposition, an optimization could be achieved with this system.
