Differences in risky sexual behaviors and HIV prevalence between men who have sex with men and transgender women in the Midwest Brazil.

Men who have sex with men (MSM) and transgender women (TW) are disproportionally affected by HIV infection. This cross-sectional study evaluated the HIV-1/2 prevalence, risk factors and HIV molecular features of MSM and TW from Midwest Brazil. Four hundred and thirty participants (278 MSM and 152 TW) from Mato Grosso do Sul, Brazil, were interviewed and tested for HIV-1/2 infection between November 2011 and September 2013. Participants who were assigned male at birth, older than 18 years old and self-declared as MSM or TW were recruited from LGBT+ associations, as well as public (parks, square, streets, etc) and private [nightclubs, saunas, brothels, etc] places. The prevalence of HIV-1 was 14.4% (9.0% among MSM and 24% among TW; p<0.001). The factor independently associated with HIV-1 infection among MSM was being 30 years-old or older. Among TW, having suffered sexual coercion, lifetime syphilis infection and hepatitis C virus exposure were associated with HIV-1 infection. Phylogenetic analyses classified 65% sequences as subtype B and 35% as possible recombinants. All but one recombinant sample were from TW individuals. High HIV-1 prevalences were observed in both groups, highlighting the urgent need to devise specific HIV interventions targeting these key populations. Notably, TWs are more vulnerable to HIV infection, which was associated with sexual violence and co-infection with other STIs. With regard to MSM, being 30 years old or older was significanty associated to HIV, reinforcing the idea that MSM are less exposed [or exposed later] to STIs than TWs, although MSM are clearly more vulnerable than the general population.

New records of Neopetrosia carbonaria (Lamarck, 1814) from the Brazilian coast reveal new morphological features and spicule types.

Sponges of the family Petrosiidae have usually a stony and brittle texture due the high silica content of the mineral skeleton that is formed by a more-or-less regular isotropic reticulation of undefined primary and secondary tracts. Neopetrosia species are distributed worldwide and twelve species are found in the Tropical Western Atlantic Ocean, of which four are recorded from the Brazilian coast. Here, we describe new Neopetrosia carbonaria specimens from several localities along the NE Brazilian coast, analyze the Neopetrosia carbonaria holotype and review the previous record of N. carbonaria from the Brazilian coast. Our study reveals new morphological features and spicule types in the Brazilian populations of N. carbonaria. Now, Neopetrosia carbonaria is defined by a thick encrusting to repent or ramose sponge, with reddish brown to brown color or dark green to black color in vivo, two categories of oxeas as megascleres and raphidiform toxas as microscleres. These toxas are quite rare and occur in both black and brown sponges. Due the absence and rarity of raphidiform toxas in some specimens, unrelated to its color, we assume that these differences are intraspecific. However, we suggest that all records of Neopetrosia carbonaria should be reevaluated, since toxas can be easily overlooked, added to the use of molecular methods to investigate the relationship between the Caribbean and Brazilian populations.

Stress and associated factors in public school teachers: a cross-sectional study.

Introduction: The search for improving productivity and performance at work has exposed workers to high levels of stress. Since the working conditions of basic education teachers interfere negatively with their health, it is important to study the entire context involving teachers, in order to encourage the promotion of workers' health actions. Objectives: To investigate stress levels and associated factors in public school teachers. Methods: The study was conducted through online questionnaires sent to public school teachers in the state of Piauí, in 2020, using the snowball method. Sociodemographic and economic characteristics and risk habits (smoking, alcoholism, and sedentary lifestyle) of the study sample were investigated, as well as clinical, anthropometric, and stress-related conditions. Results: A total of 126 teachers participated in the study, most of which were women (88.9%), had a family income from three to four minimum salaries (30.2%), and worked two shift or more (55.6%); furthermore, 10.3% reported having hypertension; 8.7%, musculoskeletal diseases; 3.2%, thyroid-related problems; and 2.4%, diabetes. A statistically significant difference in median stress levels was observed in women (p = 0.002) and in individuals with thyroid problems (p = 0.015). Conclusions: Teachers, especially women working in this job, suffer from expressive levels of stress, which can directly affect their quality of life, requiring the development of measures to prevent stress, in order to improve the health and the performance of these professionals.

Introdução: A busca por mais produtividade e desempenho no trabalho tem submetido trabalhadores a altos níveis de estresse. As condições de trabalho do professor de educação básica interferem de forma negativa sobre a sua saúde; assim, é importante que todo o contexto que envolve o professor seja estudado a fim de incentivar a promoção de ações de saúde do trabalhador. Objetivos: Verificar os níveis de estresse e fatores associados em professores de escolas públicas. Métodos: O estudo foi realizado através de questionários on-line enviados para professores de escolas públicas do Piauí, no ano de 2020, utilizando-se o método bola de neve. Foram investigadas as características sociodemográficas e econômicas, os hábitos de risco (tabagismo, alcoolismo e sedentarismo) e as condições clínicas, antropométricas e de estresse da amostra estudada. Resultados: Participaram deste estudo 126 professores, dos quais 88,9% eram mulheres, com renda familiar entre três e quatro salários-mínimos (30,2%), que trabalham em dois turnos ou mais (55,6%); 10,3% afirmaram possuir hipertensão, 8,7% disseram sofrer de doenças osteomusculares, 3,2% relataram problemas relacionados à tireoide e 2,4% são diabéticos. Foi encontrada uma diferença de medianas estatisticamente significante entre os níveis de estresse e o sexo feminino (p = 0,002) e problemas de tireoide (p = 0,015). Conclusões: Os professores, especialmente as mulheres, sofrem de níveis de estresse expressivos, o que pode afetar diretamente a qualidade de vida, sendo necessário que medidas preventivas de estresse sejam criadas a fim de melhorar a saúde e o rendimento desses profissionais.

Saúde mental na atenção básica: percepção dos Agentes Comunitários de Saúde / Mental health in primary care: perception of Community Health Workers

Resumo Introdução Os fluxos de encaminhamento dos pacientes portadores de transtornos mentais e o seu devido acolhimento representam um grande desafio na área da saúde mental. Objetivo Conhecer a percepção dos Agentes Comunitários de Saúde em relação aos usuários da saúde mental e suas atividades nesse campo. Método Estudo de ordem qualitativa utilizando a técnica de grupo focal. Os dados coletados foram transcritos e submetidos à Técnica de Análise Qualitativa de Conteúdo. Participaram do estudo 15 agentes de saúde. Resultados Os dados foram organizados utilizando os temas que se destacaram nos depoimentos dos Agentes Comunitários de Saúde e agrupados em três categorias selecionadas previamente: Conhecimento sobre Transtornos Mentais, Ações em Saúde Mental, Entraves dos Serviços. Conclusão Os agentes demonstraram interesse pelo trabalho com os pacientes, mas apontaram dificuldades envolvendo os diversos pontos da rede de atenção à saúde. Melhor preparação técnica e teórica dos agentes resultaria em ganhos para a equipe de saúde e para os pacientes. Apesar de contemplar a realidade de um município de médio porte, este estudo pode fornecer subsídios para a discussão sobre a assistência em saúde mental na atenção básica de saúde.

Abstract Background The referral flows of patients with mental disorders and their proper reception represent a major challenge in the mental health area. Objective To know the perception of Community Health Agents concerning mental health patients and their activities in this field. Method This is a qualitative study using the focus group technique. The collected data were transcribed and submitted to the Qualitative Content Analysis Technique. Fifteen health agents participated in the study. Results The data were organized using the themes that stood out in the testimonies of the Community Health Agents and grouped into three previously selected categories: Knowledge about Mental Disorders, Mental Health Actions, and Service Barriers. Conclusion The agents showed interest in working with patients but pointed out difficulties involving the different points of the healthcare network. Better technical and theoretical preparation of agents would result in gains for the health team and for patients. Despite considering the reality of a medium-sized municipality, this study can provide support for the discussion on mental health care in primary health care.

An Overview of Databases and Bioinformatics Tools for Plant Antimicrobial Peptides.

Antimicrobial Peptides (AMPs) are small, ribosomally synthesized proteins found in nearly all forms of life. In plants, AMPs play a central role in plant defense due to their distinct physicochemical properties. Due to their broad-spectrum antimicrobial activity and rapid killing action, plant AMPs have become important candidates for the development of new drugs to control plant and animal pathogens that are resistant to multiple drugs. Further research is required to explore the potential uses of these natural compounds. Computational strategies have been increasingly used to understand key aspects of antimicrobial peptides. These strategies will help to minimize the time and cost of "wet-lab" experimentation. Researchers have developed various tools and databases to provide updated information on AMPs. However, despite the increased availability of antimicrobial peptide resources in biological databases, finding AMPs from plants can still be a difficult task. The number of plant AMP sequences in current databases is still small and yet often redundant. To facilitate further characterization of plant AMPs, we have summarized information on the location, distribution, and annotations of plant AMPs available in the most relevant databases for AMPs research. We also mapped and categorized the bioinformatics tools available in these databases. We expect that this will allow researchers to advance in the discovery and development of new plant AMPs with potent biological properties. We hope to provide insights to further expand the application of AMPs in the fields of biotechnology, pharmacy, and agriculture.

Effects of whole-body vibration on muscle strength, quadriceps muscle thickness and functional capacity in kidney transplant recipients: A randomized controlled trial.

BACKGROUND: Whole-body vibration (WBV) may be an alternative of physical training for kidney transplant recipients. OBJECTIVE: To evaluate the effect of a training program on quadriceps muscle strength and thickness, distance walked in the 6-min walking test (6MWT), respiratory muscle strength and quality of life in adult kidney transplant recipients. DESIGN: Randomized controlled clinical trial. METHOD: Twelve kidney transplant recipients of both genders who underwent WBV training (35 Hz) twice a week for 12 weeks on alternate days (WBVG), and training with a Sham Group (SG) were evaluated before and after intervention. RESULTS: No difference was observed in quadriceps muscle strength and thickness between groups, however a large (d = 0.81) and a small (d = 0.44) effect size were observed after the training, respectively. Both groups improved the execution time of Sit-to-Stand Test before and after analysis, but this effect did not show superiority between them, however there was a large effect size provided by training (d = 1.11). No changes were observed between groups in relation to inspiratory muscle strength, but training effects could be observed by the effect size after the study period (d = 0.59). No changes were observed regarding the distance walked in the 6MWT and the effect size was small (d = 0.31). CONCLUSION: WBV program would induce physiological responses that must be taken into consideration in adults' kidney transplant recipients. Our results show considerable effect sizes were observed for muscle strength and quadriceps thickness, inspiratory muscle strength, and 6MWT walking distance, although no difference was observed between groups at the end of the study.

Different trophodynamics between two proximate estuaries with differing degrees of pollution.

Mangroves are complex ecosystems with widely varying abiotic factors such as salinity, pH, redox potential, substratum particle size, dissolved organic matter and xenobiotic concentrations, and a high biodiversity. This paper presents the trophodynamic pathways of accumulation and transfer of metals and metalloids (B, Al, V, Cr, Mn, Fe, Ni, Cu, Zn, Ag, As, Se, Rb, Sr, Pb and Hg), in three trophic chains (plant-crab-fish, plankton-shrimp-fish and plankton-oyster) of similar food webs, corresponding to two mangrove estuaries (Santa Cruz and Vitória Bay, separated by 70 km) in the Espírito Santo State (Brazil). Although the trophic transfer patterns are affected by physical variables, metal and metalloids were found in all trophic levels. We observed similar trophodynamics between both estuaries with some elements, but unequal transfer patterns in other cases, thus questioning the effectiveness of 15N to determine the food chain when the aquatic biota is affected by anthropogenic contaminants. Thus, in the Santa Cruz estuary, most metals were biomagnified through the food web. Conversely, Vitória Bay presented mostly biodilution, suggesting that metal/metalloid transference patterns in mangrove ecosystems may be affected by different anthropogenic contamination inputs. These results indicate the importance of knowing the complete food web when evaluating the trophic transfer of elements, including an evaluation of the differential impact of pollution on diverse components of the food chain.

Water assessment of the Itapemirim River/Espírito Santo (Brazil): abiotic and toxicogenetic aspects.

The Itapemirim River is considered one of the most important water resources in the state of Espírito Santo, Brazil. However, environmental problems due to continuous anthropogenic contamination are threatening its potential use. This study assessed water quality by analyzing abiotic and toxicogenetic aspects of the water from four stations along the river. Samples were collected in both dry and rainy seasons. Most of the abiotic variables were below the threshold established by CONAMA Resolution No. 357/2005, and so were most of the metals. However, Al and Cu contents were above those allowed by legislation, ranging from 0.2 to 0.9 mg/L. Regarding toxicogenetic aspects, genotoxic effects were observed in meristematic cells of Allium cepa, in micronucleus test and comet assay of Oreochromis niloticus, and CHO-K1 cells. Mutagenic effects were significant at RI 02 (0.34), RI 03 (0.46), and RI 04 (0.12) stations on the first campaign in A. cepa F1 cells, compared to the negative control (0.0). The second campaign revealed the same results, but with the addition of samples from RI 01 (0.17) and RI 03 (0.18) showing mutagenicity in the micronucleus test with fish erythrocytes when compared to the negative control (0.3). Essentially, all the samples evaluated in both campaigns showed damage in A. cepa, O. niloticus, and CHO-K1 cells, thus demonstrating that the water quality of the Itapemirim River is compromised and requires action plans for its recovery.

Trophic transfer of emerging metallic contaminants in a neotropical mangrove ecosystem food web.

Emerging metallic contaminants (EMCs) are of concern due their presence in aquatic ecosystems and the lack of environmental regulations in several countries. This study verifies the presence of EMCs in two neotropical mangrove estuarine ecosystems (Espírito Santo Brazil) by evaluating abiotic and biotic matrices across six trophic levels (plankton, oyster, shrimp, mangrove trees, crabs and fish) and hence interrogates the trophic transfer of these elements and their possible input sources. Using the oyster Crassostrea rhizophorae as a biomonitor, ten EMCs (Bi, Ce, La, Nb, Sn, Ta, Ti, W, Y and Zr) were determined. Bi input was from iron export and pelletizing industries; Ce, La and Y inputs were mainly associated with solid waste from steel production, while Zr, Nb and Ti were related to atmospheric particulate matter emissions. EMCs were detected at various trophic levels, showing biomagnification for most of them in the Santa Cruz estuary but biodilution in Vitória Bay. These contrasting results between the estuaries could be attributed to different pollution degrees, needing further research to be fully understood. This is the first report demonstrating EMCs trophic pathways in situ, constituting an essential baseline for future research and safety regulations involving EMCs in the environment.

Does whole body vibration training improve heart rate variability in kidney transplants patients? A randomized clinical trial.

BACKGROUND: Whole-body vibration (WBV) is an exercise modality that can promote improvements in heart rate variability (HRV) with lower patient overload, and consequently reduce cardiovascular risk in renal transplant patients. The aim of this study was to evaluate the effects of a 12-week WBV training program of two weekly sessions on HRV. METHODS: A double-blind, randomized controlled clinical trial with 12 kidney transplant recipients of both genders who underwent WBV training (35 Hz) twice a week for 12 weeks on alternate days (WBV Group) and training with sub-therapeutic WBV (8 Hz) (Sham Group). Variables were evaluated in time and frequency domains of HRV through the 24-h Holter monitor, heart rate (HR), blood pressure (BP) and maximum oxygen consumption (VO2max) through an exercise stress test. RESULTS: The delta between Sham and WBV groups showed an increase in the low frequency (Δ = 959.05 Hz; p = 0.01) and in the high frequency (Δ = 204.42 Hz; p = 0.04) of the HRV compared to Sham group. No changes in the ergometric variables were observed for any of the groups. CONCLUSION: The present study evidenced an increase in the low and high frequency of HRV in individuals who participated in the Sham WBV group. There was no improvement in the autonomic balance in the groups, in the other HRV parameters, or the exercise test after the WBV training period.

Is whole body vibration an alternative physical training method for renal transplant recipients?

OBJECTIVE: To evaluate the effect of a 12-week whole-body vibration (WBV) training program on quadriceps muscle strength, quadriceps thickness, the 6-min walk test (6MWT), respiratory muscle strength and quality of life in adults with a kidney transplant. METHOD: Five renal transplant recipients (age: 43-52 years; body mass: 67.1 kg; height: 1.60 m) were examined individually before and after a 12-week WBV program (two weekly sessions, 35 Hz frequency, 2-4 mm amplitude) using quadriceps strength, quadriceps thickness, 6-min walking test, inspiratory muscle strength and quality of life. RESULTS: There were no complications during WBV protocol, and the program was considered safe. Two of the participants changed quadriceps muscle strength, and one increased muscle thickness. Inspiratory muscle strength improved in one participant. The distance covered on 6MWT increased for two participants. Most of the subjects (P3, P4 and P5) reported improved quality of life, mainly regarding pain and social aspects. CONCLUSION: The protocol improved the physical function and quality of life in some of the patients. However, WBV training prescription should be adjusted according to individual needs. Thus, studying the use of WBV in this patient group is necessary to understand and apply the benefits for this population.

Indicador de salubridade ambiental para Campina Grande, PB: adaptações, desenvolvimentos e aplicações / Environmental health indicator for Campina Grande, PB, Brazil: adjustments, developments and applications

RESUMO A salubridade ambiental está diretamente relacionada com a qualidade dos serviços de saneamento básico, que, por sua vez, abrangem diversas ações que visam promover a melhoria da qualidade de vida das pessoas e do meio ambiente. Dessa forma, com o objetivo de avaliar as condições de salubridade do município de Campina Grande (PB), este artigo buscou desenvolver o Indicador de Salubridade Ambiental para Campina Grande (ISA/CG) a partir da adaptação do Indicador de Salubridade Ambiental do Conselho Estadual de Saneamento do Estado de São Paulo (ISA/CONESAN), desenvolvido para aplicação nesse estado. O ISA constitui um instrumento de planejamento e gestão ambiental pública que possibilita identificar as ações prioritárias em relação aos serviços de saneamento, orientando, assim, as ações dos gestores públicos e a sociedade civil na tomada de decisão para alcançar melhor qualidade de vida e ambiental. Os valores do ISA/CG foram associados aos setores censitários do distrito-sede do município para permitir, inicialmente, uma análise da distribuição espacial de seus valores na cidade. Posteriormente, para aprimorar o ISA/CG e validar seus resultados, dois novos subindicadores (conforto ambiental e capacidade de armazenamento de água) foram incorporados a partir da análise em quatro áreas-piloto, identificadas como as de mais alta e mais baixa salubridade.

ABSTRACT Environmental health is strongly related to the quality of basic sanitation services. Those services must provide a better quality of life for people and the environment. This research has developed an indicator (environmental health indicator - EHI) for assessing basic health conditions in Campina Grande, PB (Brazil). Its starting point is an adaptation of a known EHI developed by CONESAN (São Paulo, Brazil) in 1999. EHI can be a planning tool and a public environmental management tool for priorities decision-making related to basic health services. It should guide governmental policies and civil society in several decision-making processes for a better quality of life in cities. First, EHI/CG values were developed and spatialized by census track for the whole city. Second, in a validation method, two additional indicators (environmental comfort and reservoir capacity) were developed in a different scale (urban fraction). Four pilot areas were chosen based on the highest and the lowest EHI/CG values for the whole city.

Relação entre tempo de transplante renal e força muscular respiratória: série de casos / Relationship between renal transplantation time and respiratory muscle strength: case series

Introdução: O paciente com Doença Renal Crônica (DRC) apresenta alterações respiratórias que persistem após o transplante e o restabelecimento da função renal. Objetivos: Avaliar a relação entre o tempo de transplante renal e sua influência sobre a força dos músculos respiratórios. Métodos: Foram avaliados voluntários adultos atendidos no Ambulatório de Pós-Transplante Renal do Hospital das Clínicas da Universidade Federal de Pernambuco, quanto à força muscular respiratória (manovacuometria), à função pulmonar (espirometria) e o nível de atividade física (Questionário Internacional de Atividade Física ­ IPAQ). Resultados: Foram avaliados 15 voluntários no total. No grupo <154 meses de transplante renal, 57,14% dos voluntários apresentaram fraqueza muscular inspiratória (FMI), 57,14% e 71,42% apresentaram, respectivamente, redução dos valores previstos de capacidade vital forçada (CVF%) e do volume expiratório forçado no primeiro segundo (VEF1%), e 100% foram considerados ativos. No grupo ≥154 meses de transplante renal, 50% deles apresentaram FMI, 37,5% mostraram valores de CVF% e VEF1% reduzidos e 62,5% foram classificados inativos. Todos os voluntários do estudo apresentaram fraqueza muscular expiratória. Conclusão: O grupo com menor tempo de transplante apresentou maior comprometimento da força muscular respiratória, sendo observado um nível de atividade física significativamente menor no grupo com maior tempo de realização do transplante. Não houve diferença em relação à função pulmonar entre os grupos.

Introduction: The chronic renal patient has respiratory changes that persist after transplantation, even after reestablishment of renal function. Objectives: To evaluate the relationship between renal transplantation time and its influence on the strength of the respiratory muscles. Methods: Adult volunteers were evaluated at the Outpatient Renal Transplant Clinic of the Hospital das Clínicas of the Federal University of Pernambuco, regarding respiratory muscle strength by means of manovacuometry, pulmonary function by spirometry and the level of physical activity by the International Activity Questionnaire Physics ­ IPAQ. Results: A total of 15 volunteers were evaluated. In the group <154 months of renal transplantation, 57.14% of the volunteers had inspiratory muscle weakness (IMF), 57.14% presented reduced forced vital capacity (FVC) values, 71.42% had predicted expiratory volume forced in the first second reduced (FEV1%) and 100% were considered active. In the group ≥154 months of kidney transplantation, 50% had IMF, 37.5% showed FVC% and FEV1% values reduced, and 62.5% were classified as inactive. All study volunteers had expiratory muscle weakness. Conclusion: The group with shorter transplant time presented greater impairment of respiratory muscle strength, and a significantly lower level of physical activity was observed in the group with longer transplantation time. There was no difference in lung function between groups.

A webradio como instrumento de diálogo com a juventude / Webradio as an instrument of dialogue with youth

Objetivo: apresentar as experiências relativas à mobilização de jovens de escolas públicas para participarem do programa Em Sintonia com a Saúde da Webradio AJIR. Método: trata-se de um estudo descritivo, tipo relato de experiência. Compôs-se a população por alunos do nono ano, de ambos os sexos. Resultados: mobilizou-se a juventude de forma ativa e dinâmica e, durante o desenvolvimento do projeto, abordaram-se os temas tuberculose (16%), cultura e paz (15%), sexualidade (12%) relação de gênero e diversidade sexual (12%), câncer de mama (9%), tabagismo (9%), drogas de abuso (8%), primeiros socorros (7%), etilismo (6%) e métodos anticoncepcionais (6%). Observou-se que o assunto com maior participação foi a tuberculose. Conclusão: conclui-se que, apesar de as publicidades debaterem e exporem assuntos referentes aos temas palestrados, ainda existe a confusão entre os saberes, o que representa um risco biológico, principalmente. Identificou-se, ainda, que a webradio é uma tecnologia de importância, pois proporcionou, aos adolescentes, uma oportunidade de se expressarem e debaterem in loco sobre os seus interesses, o que, antes, não era possível.(AU)

Objective: to present the experiences related to the mobilization of young people from public schools to participate in the program In line with Health of Webradio AJIR. Method: it is a descriptive study, type of experience report. The population was composed by students of the ninth grade, of both sexes. Results: youth mobilized actively and dynamically, and during the development of the project the topics tuberculosis (16%), culture and peace (15%), sexuality (12%), gender relations and sexual diversity (12%), breast cancer (9%), smoking (9%), drugs of abuse (8%), first aid (7%), alcoholism (6%) and contraceptive methods (6%). It was observed that the subject with the greatest participation was tuberculosis. Conclusion: it is concluded that, although the publicity debates and expose subjects related to the themes discussed, there is still confusion between knowledge, which represents a biological risk, mainly. It was also identified that webradio is a technology of importance, as it provided the adolescents with an opportunity to express themselves and discuss their interests on the spot, which was not possible before.(AU)

Objetivo: presentar las experiencias relativas a la movilización de jóvenes de escuelas públicas para participar del programa En Sintonía con la Salud de Webradio AJIR. Método: se trata de un estudio descriptivo, tipo relato de experiencia. Se compuso la población por alumnos del noveno año, de ambos sexos. Resultados: se movilizó la juventud de forma activa y dinámica y durante el desarrollo del proyecto se abordaron los temas tuberculosis (16%), cultura y paz (15%), sexualidad (12%) relación de género y diversidad sexual (12%), cáncer de mama (9%), tabaquismo (9%), drogas de abuso (8%), primeros auxilios (7%), etilismo (6%) y métodos anticonceptivos (6%). Se observó que el tema con mayor participación fue la tuberculosis. Conclusión: se concluye que, a pesar de que las publicidades debatir y exponer asuntos referentes a los temas hablados, todavía existe la confusión entre los saberes, lo que representa un riesgo biológico, principalmente. Se identificó, además, que la webradio es una tecnología de importancia, pues proporcionó a los adolescentes una oportunidad de expresarse y debatir in situ sobre sus intereses, lo que, antes, no era posible.(AU)

Inspiratory muscle strength, diaphragmatic mobility, and body composition in chronic obstructive pulmonary disease.

BACKGROUND AND PURPOSE: Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease that can cause repercussions on respiratory muscles and body composition. The aim of the current study was to evaluate inspiratory muscle strength, diaphragmatic mobility, and body composition in COPD subjects and to correlate these variables. METHODS: This was a cross-sectional study performed with 21 COPD patients. Inspiratory muscle strength (manovacuometry), pulmonary function test (forced vital capacity [FVC], forced expiratory volume in 1 s [FEV1 ], and FEV1 /FVC ratio), diaphragmatic mobility (ultrasonography), and body composition (bioelectrical impedance analysis) were examined. RESULTS: COPD individuals in Stages II (28.9%), III (52%), and IV (19%) according to Global Initiative for Chronic Obstructive Disease were recruited, 61.9% of which were men. Inspiratory muscle weakness was found in 47.6% of subjects, who presented a lower fat-free mass percentage (p = 0.017) and smaller fat-free mass index (p = 0.001) and greater fat mass percentage (p = 0.029) and less diaphragmatic mobility (p = 0.007) compared with the nonrespiratory weakness group. Maximal inspiratory pressure exhibited a moderately positive relationship to the fat-free mass index (r = 0.767, p < 0.001) and a weak positive relationship to diaphragmatic mobility (r = 0.496, p = 0.022). CONCLUSION: Our study showed a high prevalence of inspiratory muscle weakness based on the severity of airway obstruction and on the presence of muscular depletion. The evaluation of body composition detected important changes. It also demonstrated that not only muscular weakness was present in these patients but also this had repercussions on the mobility of the diaphragm muscle.

Riscos para o desencadeamento da osteoporose em idosos / Risks for development of osteoporosis in the elderly

Objetivo: conhecer os riscos para o desencadeamento da osteoporose nos idosos. Método: trata-se de estudo quantitativo, transversal e descritivo na Estratégia Saúde da Família (ESF). Utilizou-se, para a coleta de dados, um instrumento composto por características sociodemográficas, antropometria, variáveis clínicas e hábitos de vida. Analisaram-se os resultados por meio do programa SPSS, versão 20.0, e se apresentaram os achados em tabelas. Resultados: prevaleceram-se as doenças hipertensão arterial e diabetes mellitus. Encontrou-se, sobre o histórico familiar, o fato de os idosos nunca terem apresentado fratura, não possuírem fatores genéticos sobre a osteoporose e não fazerem uso de cálcio e vitamina D. Com relação aos fatores modificáveis, grande parte dos idosos afirmou não praticar atividade física, não se expor ao Sol, ingerir bastante cafeína e leite. Conclusão: atingiu-se o objetivo proposto e espera-se que os resultados encontrados contribuam na construção do conhecimento sobre essa doença de crescente acometimento auxiliando a elaboração de estratégias de prevenção ou evitando possíveis complicações.(AU)

Nanoparticle transport and sequestration: Intracellular titanium dioxide nanoparticles in a neotropical fish.

Intracellular titanium dioxide nanoparticles (TiO2-NP) with rutile crystalline form and dimensions varying from 43 to 67 nm × 64 to 93 nm are reported for the first time as being sequestered from the environment. TiO2-NP were identified inside all organs/tissues (muscle, kidney, gonad, hepatopancreas and gill) in both the cytoplasm and nucleus of the neotropical fish Centropomus parallelus, captured in an area affected by metallurgical activity. Atmospheric particulate matter (PM) sampled in the same area showed the presence of TiO2-NP with the same rutile crystalline form and dimensions varying from 16 to 93 nm × 45 to 193 nm, thus indicating the smelting and iron processing industries as the most probable source of TiO2-NP. In any sample, chemical analyses identify and quantify Ti concentration and nanocrystallography identified the structure of TiO2-NP. The Ti concentration in the sediment and atmospheric PM varied between years and it was mirrored by the Ti concentration in the fish organs. The gill has a higher Ti concentration varying from 5.50 to 14.57 µg g-1 dry weight and the gonad was the organ with lowest Ti level, 0.25 to 0.87 µg g-1 dry weight. In the muscles, Ti concentration varied from 0.85 to 3.34 µg g-1 dry weight. This contamination may be likely to affect the surrounding biota and food uptake, including the humans living in the city close to the metallurgical complex. These findings emphasised the needs to improve methods to reduce PM (including nanoparticles) arising from human activities and to evaluate the toxicokinetic and effects of TiO2-NP in the biota and human health.

Comportamento da variabilidade da frequência cardíaca e da capacidade funcional de acordo com o tempo de transplante renal / Behavior of variability of heart rate and functional capacity according to renal transplant time

Introdução: Desequilíbrio autonômico, com aumento da atividade simpática e redução da parassimpática, pode ocorrer no transplantado renal, representando forte indicador de risco cardíaco. Objetivo: Avaliar a variabilidade da frequência cardíaca (VFC) e a capacidade funcional dos transplantados renais de acordo com o tempo de transplante renal. Métodos: Série de casos envolvendo transplantados renais divididos em grupos de acordo com a mediana do tempo de transplante renal (158 meses). Foram avaliados a VFC através do Holter por 24 horas, o nível de atividade física (IPAQ) e o desempenho funcional (teste de caminhada de 6 minutos). Resultados: Os indivíduos comportaram-se diferentemente em relação à VFC e à capacidade funcional. No entanto, aqueles com maior tempo de transplante apresentaram maior VFC, eram menos ativos e variaram mais no desempenho funcional. Conclusão: O presente estudo constata a presença de diferenças individuais na VFC e no desempenho funcional entre os transplantados renais de acordo com o tempo de realização do TX.

Introduction: Autonomic imbalance, with increased sympathetic activity and reduction of parasympathetic activity, may occur in the renal transplantation patient, representing a strong indicator of cardiac risk. Objective: To assess heart rate variability (HRV) and functional capacity of kidney transplantation recipients according to the time of transplantation. Methods: A case series involving renal transplant recipients divided into groups according to the median of kidney transplantation time (158 months). HRV was evaluated through 24-hour Holter monitoring, physical activity level (IPAQ) and functional performance (6-minute walk test). Results: The individuals behaved differently in relation to HRV and functional capacity. Those with longer transplantation had higher HRV, were less active and presented more diverse functional performance. Conclusion: The present study notes the presence of individual differences in HRV and functional performance between renal transplants according to the time of TX.

Risco de quedas e qualidade de vida no distúrbio mineral e ósseo da doença renal: estudo transversal / Risk of falls and quality of life in chronic kidney disease patients with mineral and bone disorder: cross-sectional study

Introdução: As anormalidades ósseas em doentes renais crônicos tornam-nos mais propensos a fraturas que a população geral, além da exposição a eventos clínicos relacionados à queda, que podem interferir na qualidade de vida. Objetivo: Avaliar o risco de quedas e qualidade de vida em doentes renais crônicos com distúrbio mineral e ósseo. Métodos: Estudo transversal, envolvendo 50 pacientes classificados em dois grupos: baixa remodelação (n=20) e alta remodelação (n=30). Foram registrados dados sociodemográficos e clínicos, avaliado o risco de quedas (Escala Internacional de Eficácia de Quedas) e a qualidade de vida (Medical Outcomes Study SF-36). Resultados: A prevalência de risco de quedas entre os pacientes de baixa e de alta remodelação foi 65% e 50% respectivamente, além de um maior comprometimento do estado geral de saúde, avaliado pelo SF-36, nos dois grupos. Conclusão: Foi observado risco elevado de quedas com maior comprometimento dos aspectos físicos relacionados à qualidade de vida.

Introduction: Bone abnormalities in chronic kidney patients make them more prone to fractures than the general population, in addition to exposure to clinical events related to fall, which may interfere with their quality of life. Objective: To evaluate the risk of falls and quality of life in chronic kidney patients with mineral and bone disorders. Methods: A cross-sectional study involving 50 patients classified into two groups: low remodeling (n = 20) and high remodeling (n = 30). Sociodemographic and clinical data were recorded, assessing the risk of falls (International Falls Efficiency Scale) and quality of life (Medical Outcomes Study SF-36). Results: The prevalence of risk of falls among low and high remodeling patients was 65% and 50%, respectively, as well as a greater impairment of SF-36 in both groups. Conclusion: There was a high risk of falls with greater impairment of physical aspects related to quality of life.

Does blood flow restriction training increase the diameter of forearm vessels in chronic kidney disease patients? A randomized clinical trial.

INTRODUCTION:: Blood flow restriction training can be used as an alternative to conventional exercise in chronic kidney disease patients with indication of arteriovenous fistula. OBJECTIVE:: Evaluating the efficacy of blood flow restriction training in the diameter and distensibility change of the cephalic vein and the diameter and flow of the radial artery, muscle strength and forearm circumference in chronic kidney disease patients with arteriovenous fistula pre-creation. METHODS:: A blind randomized clinical trial consisting of 26 chronic kidney disease patients allocated into a blood flow restriction training group (blood flow restriction; n = 12) and a group without blood flow restriction training (control group; n = 14). Blood flow restriction was performed at 50% of systolic blood pressure and using 40% of handgrip strength as load for the isometric exercises in both groups. RESULTS:: An increase in the diameter of the cephalic vein in the 2 cm (p = 0.008) and 10 cm segments (p = 0.001) was observed in the control group. The diameter of the radial artery increased in all segments in the blood flow restriction group (2, 10 and 20 cm; p = 0.005, p = 0.021 and p = 0.018, respectively) and in the 10 and 20 cm segments (p = 0.017 and p = 0.026) in the control group. Handgrip strength only increased in the control group (p = 0.003). CONCLUSION:: Physical training associated with blood flow restriction increased cephalic vein diameters in both groups and was effective in increasing the diameter of the radial artery; however, it did not demonstrate superiority over the exercise group protocol without blood flow restriction.