1.
Org Biomol Chem
; 14(29): 6947-50, 2016 Aug 07.
Article
in English
| MEDLINE
| ID: mdl-27356738
ABSTRACT
A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.