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Bioorg Med Chem Lett ; 10(15): 1751-4, 2000 Aug 07.
Article in English | MEDLINE | ID: mdl-10937740

ABSTRACT

A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active.


Subject(s)
Anti-Bacterial Agents/pharmacology , Staphylococcus aureus/drug effects , Anti-Bacterial Agents/chemistry , Indoles/chemistry , Indoles/pharmacology , Microbial Sensitivity Tests , Structure-Activity Relationship
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