ABSTRACT
EUSOMA (The European Society of Breast Cancer Specialists) is committed to writing recommendations on different topics of breast cancer care which can be easily adopted and used by health professionals dedicated to the care of patients with breast cancer in their daily practice. In 2011, EUSOMA identified the management of young women with breast cancer as one of the hot topics for which a consensus among European experts was needed. Therefore, the society recently organised a workshop to define such recommendations. Thirteen experts from the different disciplines met for two days to discuss the topic. This international and multidisciplinary panel thoroughly reviewed the literature in order to prepare evidence-based recommendations. During the meeting, two working groups were set up to discuss in detail diagnosis and loco-regional and systemic treatments, including both group aspects of psychology and sexuality. The conclusions reached by the working groups were then discussed in a plenary session to reach panel consensus. Whenever possible, a measure of the level of evidence (LoE) from 1 (the highest) to 4 (the lowest) degree, based on the methodology proposed by the US Agency for Healthcare Research and Quality (AHRQ), was assigned to each recommendation. The present manuscript presents the recommendations of this consensus group for the management of young women with breast cancer in daily clinical practice.
Subject(s)
Breast Neoplasms/therapy , Adult , Age of Onset , Breast Implants , Breast Neoplasms/diagnosis , Breast Neoplasms/epidemiology , Breast Neoplasms/genetics , Breast Neoplasms/prevention & control , Carcinoma, Intraductal, Noninfiltrating/therapy , Chemotherapy, Adjuvant , Disease Management , Female , Fertility Preservation , Humans , Lactation , Magnetic Resonance Imaging , Mammography/methods , Mammography/statistics & numerical data , Mass Screening , Mastectomy/methods , Mastectomy/statistics & numerical data , Menopause, Premature , Neoplasm Staging/methods , Neoplastic Syndromes, Hereditary/diagnosis , Neoplastic Syndromes, Hereditary/epidemiology , Osteoporosis/prevention & control , Pregnancy , Pregnancy Complications, Neoplastic/therapy , Radiotherapy, Adjuvant , Sentinel Lymph Node Biopsy , Young AdultSubject(s)
Breast Neoplasms/radiotherapy , Radiation Injuries/etiology , Radiation Injuries/prevention & control , Radiation Protection/methods , Radiotherapy, Adjuvant/adverse effects , Radiotherapy, Conformal/adverse effects , Dose Fractionation, Radiation , Female , Humans , Postoperative Care/adverse effects , Postoperative Care/methodsSubject(s)
Health Services Needs and Demand , Professional Role , Radiology , Australia , Clinical Competence , Humans , Radiology/education , WorkforceSubject(s)
Breast Neoplasms/therapy , Antineoplastic Agents/therapeutic use , Antineoplastic Agents, Hormonal/therapeutic use , Aromatase Inhibitors/therapeutic use , Biopsy, Fine-Needle , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Carcinoma, Ductal, Breast/drug therapy , Carcinoma, Ductal, Breast/radiotherapy , Carcinoma, Ductal, Breast/surgery , Carcinoma, Ductal, Breast/therapy , Chemotherapy, Adjuvant , Combined Modality Therapy , Female , Humans , Mastectomy , Neoadjuvant Therapy , Tamoxifen/therapeutic useSubject(s)
Global Health , Health Promotion , Mortality , Nicotiana/adverse effects , Smoking/adverse effects , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Smoking PreventionSubject(s)
Breast Neoplasms/therapy , Antineoplastic Agents/therapeutic use , Antineoplastic Agents, Hormonal/therapeutic use , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Carcinoma, Ductal, Breast/drug therapy , Carcinoma, Ductal, Breast/radiotherapy , Carcinoma, Ductal, Breast/surgery , Carcinoma, Ductal, Breast/therapy , Chemotherapy, Adjuvant , Combined Modality Therapy , Female , Humans , Mastectomy , Neoadjuvant Therapy , Tamoxifen/therapeutic useSubject(s)
Health Personnel , Health Promotion , Smoking Prevention , World Health Organization , Health Facilities , Humans , RoleABSTRACT
Despite it being confusing, inherently inequitable, and subject to excessive federal government control, Australia provides good healthcare.
Subject(s)
Delivery of Health Care , Australia , Delivery of Health Care/economics , Emigration and Immigration , Humans , Medicare , Quality of Health Care , United Kingdom/ethnologySubject(s)
Breast Neoplasms/therapy , Antineoplastic Agents/therapeutic use , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Carcinoma, Ductal/radiotherapy , Carcinoma, Ductal/surgery , Carcinoma, Ductal/therapy , Combined Modality Therapy , Female , Humans , Mastectomy , Tamoxifen/therapeutic useABSTRACT
BACKGROUND: Breast conservation surgery and subsequent radiotherapy is an acceptable method of treating breast cancer. Complete excision of the primary tumour is important to minimize the risk of local recurrence. Re-excision is usually carried out if the initial primary tumour excision shows positive margins. However, a significant proportion of re-excision specimens are negative for tumour. The aim of the present study was to identify factors predicting a histologically positive re-excision specimen. METHODS: The case records of all patients with invasive and in situ breast cancer referred to the William Buckland Radiotherapy Centre between January 1996 and December 2001 were reviewed. The factors evaluated were patient age, whether or not tumours were detected by screening mammography, use of hook-wire needle localization, whether tumours were marked with orientating sutures, histopathological characteristics of the tumour and involvement of axillary nodes. Univariate analysis was performed. RESULTS: In the study period, a total of 1128 patients were reviewed. Of these, 742 underwent breast conservation surgery. Twenty-nine (3.9%) of the 742 had positive surgical margins and underwent re-excision. Data were insufficient for six, leaving 23 patients eligible for the study. The number of patients entering the study was small, limiting the statistical analysis. Of these, 21 patients had invasive cancer and two patients had ductal carcinoma in situ only. Of 23 re-excisions, 11(48%) contained residual tumour. Univariate analysis of the data revealed no significant factors that were likely to predict tumour in the re-excision specimen. The local recurrence after re-excision in patients with positive margins was 4.3%. CONCLUSION: The results suggest that it is not possible to predict which patients will have tumour in the re-excision specimen. However, approximately 50% of re-excision specimens showed residual cancer. Therefore it is recommended that all excisions with positive margins need further surgery.
Subject(s)
Breast Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Breast Neoplasms/pathology , Humans , Middle Aged , Neoplasm, Residual , Predictive Value of Tests , Reoperation , Risk FactorsSubject(s)
Breast Neoplasms/therapy , Antineoplastic Agents, Hormonal/therapeutic use , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Carcinoma, Ductal, Breast/radiotherapy , Carcinoma, Ductal, Breast/surgery , Carcinoma, Ductal, Breast/therapy , Combined Modality Therapy , Female , Humans , Mastectomy , Tamoxifen/therapeutic useABSTRACT
The objective of this study was to examine the feasibility, implementation, acceptability and impact of an evidence-based specialist breast care nurse (SBN) model of care in Australia. Primary data were collected from four diverse Australian breast cancer treatment centres over a 12-month period. The design was a multicentre demonstration project. Information about the provision of care and patient needs was collected through prospective logs. Structured interviews were conducted with women who received the SBN intervention (N = 167) and with a control group of women treated prior to the intervention period (N = 133). Health professionals (N = 47) were interviewed about their experience of the SBN. Almost all women had contact with an SBN at five scheduled consultations and 67% of women in the intervention group requested at least one additional consultation with the SBN. Women in the intervention group were more likely to receive hospital fact sheets and to be told about and participate in clinical trials. Ninety-eight per cent of women reported that the availability of an SBN would affect their choice of hospital, with 48% indicating that they would recommend only a hospital with a SBN available. Health professionals reported that SBNs improved continuity of care, information and support for the women, and resulted in more appropriate referrals and use of the time of other members of the team. In conclusion, the SBN model is feasible and acceptable within diverse Australian treatment centres; there is evidence that some aspects of care were improved by the SBN.