1.
Org Biomol Chem
; 17(37): 8551-8560, 2019 09 25.
Article
in English
| MEDLINE
| ID: mdl-31528940
ABSTRACT
Polyene cyclisations are a powerful method for the direct generation of molecular complexity. This paper describes the use of computational methods to investigate the stereoselectivity of cationic polyene cyclisations of geranylbenzene derivatives. The outcomes highlight the different reactivity of hyperconjomers during the key Friedel-Crafts alkylation step, and informed a successful strategy for the synthesis of (±)-taiwaniaquinone G with improved levels of stereoselectivity.