ABSTRACT
This comparative study of the influence of cytoflavin and cardioxipin on the parameters of 24-hour arterial pressure monitoring in 56 patients with chronic cerebral circulation insufficiency, arterial hypertension and hypercholesterolemia included 32 women and 24 men aged 42-72 years divided into 3 groups matchedfor the stage of diseases, age, sex, severity of AH, total cholesterol level, and antihypertensive therapy. Patients of group 1 were treated without cytoflavin and cardioxipin. Those in group 2 received daily i/v droplet infusion of 10 mg/kg cardioxipin (20-30 droplets/min). Patients of group 3 were given daily i/v droplet infusion of 10 ml cytoflavin in 200 ml 0.9% sodium chloride solution for 10 days. 24-hour arterial pressure monitoring was used to estimate the influence of the two drugs on systolic and diastolic pressure, its daily rhythm, AP variability and frequency of elevation. The study showed that both therapeutic modalities improved daily AP rhythm as manifested in a significant increase of the number of patients with the dipper rhythm and a decrease in the number of systolic/diastolic non-dipper patients. Moreover cytoflavin significantly decreased the number of systolic over-dippers compared with control group.
Subject(s)
Antihypertensive Agents/administration & dosage , Arterial Pressure/drug effects , Blood Pressure Monitoring, Ambulatory/methods , Cerebrovascular Disorders/drug therapy , Flavin Mononucleotide/administration & dosage , Hypercholesterolemia/drug therapy , Hypertension/drug therapy , Inosine Diphosphate/administration & dosage , Niacinamide/administration & dosage , Succinates/administration & dosage , Adult , Aged , Cerebrovascular Circulation/drug effects , Cerebrovascular Disorders/complications , Cerebrovascular Disorders/physiopathology , Chronic Disease , Dose-Response Relationship, Drug , Drug Combinations , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Hypercholesterolemia/complications , Hypercholesterolemia/physiopathology , Hypertension/complications , Hypertension/physiopathology , Infusions, Intravenous , Male , Middle Aged , Retrospective Studies , Treatment OutcomeABSTRACT
OBJECTIVE: To compare the effects of cytoflavin and cardioxipin on the emotional status of rats with experimental disturbance of lipid metabolism using the uplifted cruciform labyrinth method. MATERIAL AND METHODS: The disturbance of lipid metabolism was induced by the introduction of exogenic cholesterol-in -oil emulsion in dosage 40 mg /kg of body mass during 20 days. Pharmacological treatment was performed in the 11th day. The drugs were injected intraperitoneally during 10 days: cytoflavin in dose 1,75 ml/ kg (175 mg/kg with succinic acid), cardioxipin in dose 52,5 mg/kg. RESULTS AND CONCLUSION: Cytoflavin and cardioxipin caused the positive changes in the parameters of emotional status of rats in conditions of experimental dyslipidemia.
Subject(s)
Anxiety/prevention & control , Dyslipidemias/psychology , Emotions/drug effects , Flavin Mononucleotide/administration & dosage , Inosine Diphosphate/administration & dosage , Niacinamide/administration & dosage , Picolines/administration & dosage , Succinates/administration & dosage , Animals , Disease Models, Animal , Drug Combinations , Male , RatsABSTRACT
Comparative tests on nonlinear rats of both sex with model violation of lipid metabolism have been performed in order to study the effects of cytoflavin (1.75 ml/kg or 175 mg/kg with respect to succinic acid) and cardioxipin (52.5 mg/kg) on lipid peroxidation and antioxidant protection indices in the blood. It is established that these preparations cause a decrease in the content of malonic dialdehyde (MDA) in erythrocytes that results in increased antioxidant activity and lipid reserves for peroxidation in the blood.
Subject(s)
Antioxidants/metabolism , Dyslipidemias/drug therapy , Erythrocytes/drug effects , Flavin Mononucleotide/pharmacology , Inosine Diphosphate/pharmacology , Niacinamide/pharmacology , Protective Agents/pharmacology , Pyridones/pharmacology , Succinates/pharmacology , Animals , Animals, Outbred Strains , Catalase/blood , Drug Combinations , Dyslipidemias/blood , Erythrocytes/chemistry , Erythrocytes/metabolism , Female , Lipid Peroxidation/drug effects , Male , Malondialdehyde/antagonists & inhibitors , Malondialdehyde/blood , Rats , Superoxide Dismutase/bloodABSTRACT
We studied the effect of dicarbamine and leucostim on myelopoiesis in experimental post-radiation bone marrow syndrome. Dicarbamine in different modes of administration and doses provided a high level of protection of proliferating hematopoietic precursors in the early period after radiation, which was reflected in a statistically significant decrease in the depth and duration of post-radiation deficit of cells, such as of granulocytes, lymphocytes, megakaryocytes and erythroid cells. The greatest effect of the drug appeared at a dose of 4 mg/kg (prophylactic administration) and a dose of 15 mg/kg (curative double dose). In the bone marrow of experimental animals leucostim prevented development of post-radiation deficit of granulocytes and lymphocytes to a lesser extent, than dicarbamine, and it was effective for erythroid cells and megakaryocytes.
Subject(s)
Bone Marrow Cells/drug effects , Bone Marrow Cells/radiation effects , Caproates/pharmacology , Granulocyte Colony-Stimulating Factor/pharmacology , Hematopoietic Stem Cells/drug effects , Imidazoles/pharmacology , Radiation-Protective Agents/pharmacology , Animals , Bone Marrow/drug effects , Bone Marrow/radiation effects , Caproates/administration & dosage , Dose-Response Relationship, Drug , Granulocyte Colony-Stimulating Factor/administration & dosage , Granulocytes/drug effects , Granulocytes/radiation effects , Hematopoietic Stem Cells/radiation effects , Imidazoles/administration & dosage , Male , Megakaryocytes/drug effects , Megakaryocytes/radiation effects , Rabbits , Radiation-Protective Agents/administration & dosage , Syndrome , Time FactorsABSTRACT
The condition of the mucous membrane and lipid spectrum of tissue structures under the action of gastric ulcerogenic stress factors was studied on the background of administration of vitamin E, dimephosphon, and reamberin. The use of antioxidants, especially reamberin, led to the restoration of lipid metabolism and normalization of lipid peroxidation processes.
