[Biochemical and morphological changes in white rat lung and liver tissues in experimental paraquat poisoning]. / Biokhminicheskie i morfologicheskie izmeneniia v tkaniakh legkikh i pecheni belykh krys pri éksperimental'noi intoksikatsii parakvatom.

Superoxide dismutase (SOD) activity, the number of free radicals and pathomorphological changes were studied in lung and liver tissues of white rats with experimental paraquat poisoning. It was shown that SOD activity in the lungs and liver decreased and the number of free radicals rose. The inhibition of SOD activity after repeated administration of paraquat (1/10 of LD50) was more pronounced than in acute poisoning. Dystrophic and proliferative histomorphological changes characteristic for acute and chronic experiments and disturbed vascular permeability were revealed. It is suggested that the toxic action of paraquat on the animals is particularly consequent on the lack of SOD activity and enhancement of free radical processes.

[Blastomogenic activity of substance complexes that leached out of rubbers into food media]. / Blastomogennaia aktivnost' kompleksov veshchestv, vymyvaemykh v pishchevye sredy iz rezin.

The complex of agents migrating from low-dispersed soot resins PM-15 and PGM-33, injected in the stomach or applied onto the skin of mice C57Bl, showed an insignificant blastomogenic activity. Most sensitive to their effect were the tissues of organs at the site of injection (proventricular papillomas in 8.3% of cases, skin papillomas in 12.5%), in the lung (adenomas in 12.5%) and in the pancreas (fibroadenoma in 4.2%). In the negative control groups of animals no tumors of such localization were noted. The whole complex of substances migrating from resins renders the blastomogenic effect, i. e. there is a combined action with an enhancement of blastomogenic effect.