ABSTRACT
UNLABELLED: The aim of the research is to improve diagnosis and assessment of severity and prognosis with different forms of acute pancreatitis. In 79 patients were studied levels of leukocytes, lymphocytes, leucocyte intoxication index (LII), the content of lactate dehydrogenase (LDG), creatinephosphokinase (CPK), amylase, aspartate aminotransferase (AST, alanine aminotransferase (ALT). RESULTS: The level of leukocytes reflects the severity of the disease, but had no prognostic value. The level of lymphocytes, LII. LDG and lipase reflect the severity, of the disease and have prognostic value. The level of amylase, AST, ALT, CPK not always reflect the severity of the disease, but had prognostic value. CONCLUSION: The most readily available to assess the severity and prognosis in acute pancreatitis are the level of blood lymphocytes and LII. Indicators LDG. CPK, amylase, lipase, AST and ALT also reflect the course and prognosis of the disease.
Subject(s)
Pancreatitis/blood , Severity of Illness Index , Acute Disease , Adult , Aged , Aged, 80 and over , Amylases/blood , Biomarkers/blood , Creatine Kinase/blood , Female , Humans , L-Lactate Dehydrogenase/blood , Leukocyte Count , Lipase/blood , Lymphocyte Count , Male , Middle Aged , Pancreatitis/enzymology , Pancreatitis/mortality , Pancreatitis, Acute Necrotizing/blood , Pancreatitis, Acute Necrotizing/enzymology , Pancreatitis, Acute Necrotizing/mortality , Predictive Value of Tests , PrognosisABSTRACT
The comparative analysis of blood levels of leukocytes, lymphocytes, the leukocytic intoxication index, amylase, lipase, lactatdehydrogenase and creatinphosphokinase, measured in operated patients with the acute pancreatitis, demonstrated the general positive dynamics of the patients condition. The higher blood levels of the substances in died patients demonstrate the important prognostic value of them. The higher levels of amylase, lipase, lactatdehydrogenase and creatinphosphokinase by the end of the clinical treatment together with the normalization of the rest laboratory data may witness the higher risk of the chronisation of the pancreatitis.
Subject(s)
Clinical Chemistry Tests/methods , Leukocytes/metabolism , Pancreas/surgery , Pancreatectomy , Pancreatitis, Acute Necrotizing , Pancreatitis, Chronic , Adult , Aged , Biomarkers/blood , Disease Progression , Female , Humans , Male , Middle Aged , Monitoring, Physiologic , Pancreas/diagnostic imaging , Pancreas/metabolism , Pancreatectomy/adverse effects , Pancreatectomy/methods , Pancreatitis, Acute Necrotizing/complications , Pancreatitis, Acute Necrotizing/diagnosis , Pancreatitis, Acute Necrotizing/enzymology , Pancreatitis, Acute Necrotizing/mortality , Pancreatitis, Acute Necrotizing/surgery , Pancreatitis, Chronic/etiology , Pancreatitis, Chronic/metabolism , Pancreatitis, Chronic/prevention & control , Prognosis , Treatment Outcome , UltrasonographyABSTRACT
Investigation of white blood cell and lymphocyte concentration and white blood cell intoxication index (WBCII), integral systems APACHE II and Ranson reliably reflected the severity of clinical status in patients with acute pancreatitis and had prognostic value. At the same time white blood cell concentration and indices of APACHE II reflected to lesser extent the severity of clinical status, and white blood cell concentration didn't have any prognostic value. Application of lymphocyte concentration and WBCII can be recommended in urgent surgery for evaluation of clinical status and prognosis at early stages of diagnostics and treatment of acute pancreatitis.
Subject(s)
Acute Disease , Severity of Illness Index , APACHE , Humans , Pancreatitis , PrognosisABSTRACT
Investigation of indices of lactate dehydrogenase (LDG) and creatine phosphokinase (CPK) in a group of patients with extensive necrotic alterations in organs of the abdominal cavity and in a group of patients without extensive necroses has shown that in the first group there were higher levels of LDG and CPK. It shows that the LDG and CPK indices may be used as markers of tissue necrosis of the abdominal organs. In addition, in patients who died against the background of growing polyorganic insufficiency the LDG and CPK level by the end of treatment was statistically reliably higher than on admission of the same patients that may be an indicator of growing phenomena of dystrophy and micronecroses in vitals, so the indices of LDG and CPK may show the degree of severity of polyorganic insufficiency and determine its prognosis.
